Effects of immunological processes and mild ambient atmosphere alterations on the brain in health and disease [0.03%]
免疫过程和轻微环境改变对健康和疾病状态下大脑的影响
Piotr Walczak,Xunming Ji,Shen Li et al.
Piotr Walczak et al.
Xuming Ji,Piotr Walczak,Johannes Boltze
Xuming Ji
Mesenchymal stem cell-derived exosomes: Shaping the next era of stroke treatment [0.03%]
间充质干细胞衍生的外泌体：塑造中风治疗的新时代
Arshi Waseem,Saudamini,Rizwanul Haque et al.
Arshi Waseem et al.
Exosome-based treatments are gaining traction as a viable approach to addressing the various issues faced by an ischemic stroke. These extracellular vesicles, mainly produced by Mesenchymal Stem Cells (MSCs), exhibit many properties with su...
Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI) [0.03%]
阿尔茨海默病神经保护研究计划(ADNRI)：在阿尔茨海默病患者中保持认知功能
Jie Liu,Heleen van Beusekom,Xian-Le Bu et al.
Jie Liu et al.
The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of amyloid-β (Aβ) has been proposed as a significant pathomechan...
Mononuclear cell therapy of neonatal hypoxic-ischemic encephalopathy in preclinical versus clinical studies: a systematic analysis of therapeutic efficacy and study design [0.03%]
单核细胞治疗新生儿缺氧缺血性脑病的临床前与临床研究：治疗效果和研究设计的系统分析
Alexander M Scrutton,Francesca Ollis,Johannes Boltze
Alexander M Scrutton
Background: Hypoxic-ischemic encephalopathy (HIE) is a devastating condition affecting around 8.5 in 1000 newborns globally. Therapeutic hypothermia (TH) can reduce mortality and, to a limited extent, disability after HIE...
Attenuation of amyotrophic lateral sclerosis via stem cell and extracellular vesicle therapy: An updated review [0.03%]
通过干细胞和细胞外囊泡疗法减轻肌萎缩侧索硬化：最新综述
Gavin Lockard,Jonah Gordon,Samantha Schimmel et al.
Gavin Lockard et al.
Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurological disease characterized by upper and lower motor neuron degeneration. Though typically idiopathic, familial forms of ALS are commonly comprised of a superoxide dismutase 1 (S...
Activation of neurogenesis in the hippocampus is a novel therapeutic target for Alzheimer's disease [0.03%]
在海马区激活神经发生是阿尔茨海默症的新型治疗方案
Akihiko Taguchi,Yuka Okinaka,Akiko Takeda et al.
Akihiko Taguchi et al.
Exploring novel experimental treatments for major neurodegenerative disorders [0.03%]
探索针对主要神经退行性障碍的新实验疗法
Xunming Ji,Piotr Walczak,Johannes Boltze
Xunming Ji
3D printing-based frugal manufacturing of glass pipettes for minimally invasive delivery of therapeutics to the brain [0.03%]
基于3D打印的微创输送疗法到大脑的玻璃吸管廉价制造法
Guanda Qiao,David Gulisashvili,Anna Jablonska et al.
Guanda Qiao et al.
Objective: Intracerebral delivery of agents in liquid form is usually achieved through commercially available and durable metal needles. However, their size and texture may contribute to mechanical brain damage. Glass pip...
Ex vivo 100 μm isotropic diffusion MRI-based tractography of connectivity changes in the end-stage R6/2 mouse model of Huntington's disease [0.03%]
基于离体100μm各向同性扩散MRI的亨廷顿舞蹈病终末期R6/2小鼠模型连接变化的示踪成像研究
Ashwinee Manivannan,Lesley M Foley,T Kevin Hitchens et al.
Ashwinee Manivannan et al.
Background: Huntington's disease is a progressive neurodegenerative disorder. Brain atrophy, as measured by volumetric magnetic resonance imaging (MRI), is a downstream consequence of neurodegeneration, but microstructura...