Serum elemental profile-based machine learning models for Alzheimer's disease identification and cognitive score prediction [0.03%]
基于血清元素谱的机器学习模型在阿尔茨海默病识别和认知评分预测中的应用
Haotian Liu,Xinnan Liu,Yashuang Chen et al.
Haotian Liu et al.
Background: Current diagnostic approaches for Alzheimer's disease (AD) largely rely on cerebrospinal fluid biomarkers and neuroimaging, which may be invasive, costly, and not readily accessible in routine clinical setting...
Global trends in epilepsy and the Chinese experience: Epidemiological transitions, underlying mechanisms, and integrated strategies (1990-2021) [0.03%]
全球癫痫流行趋势及中国经验：癫痫流行转变、发病机制和综合防控策略（1990-2021）
Ting Chen,Mengqiao He,Sijia Basang et al.
Ting Chen et al.
Epilepsy represents a global public health challenge, with its burden distribution profoundly illuminating patterns of health inequality. Based on the Global Burden of Disease Study 2021 (GBD 2021) data, this review constructs a three-dimen...
Could limb laterality influence the efficacy of remote postischemic conditioning after stroke? [0.03%]
肢体横向性会影响卒中后远隔缺血预适应的效果吗？
Hansen Chen,Gary K Steinberg
Hansen Chen
Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline [0.03%]
分级的创伤性脑损伤严重程度不同地调节小胶质细胞和星形胶质细胞极化状态及对米诺环素的反应
Yan Yu,Chen Wang,Jinyu Zhu et al.
Yan Yu et al.
Background: Traumatic brain injury (TBI) involves complex secondary injury cascades in which neuroinflammation is a prominent driver. The lack of standardized models capturing a spectrum of injury severities has hindered ...
Prime editing in neuropsychiatric disorders: From mutation-specific target selection to clinical translation [0.03%]
精神神经疾病中的prime编辑：从特定突变靶点选择到临床转化
Tianshan Ji,Yuan Zhang,Jinyi Zhao et al.
Tianshan Ji et al.
Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)-based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR-associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)-e...
Post-Omicron cognitive decline is largely reversible: Two-year multicenter cohort study of domain-specific outcomes in hospitalized patients [0.03%]
奥密克戎后认知功能下降大多可以逆转：住院患者的多中心队列研究中特定领域的结果两年随访
Min Qiu,Mengwen Wang,Shengcai Chen et al.
Min Qiu et al.
Background: Cognitive impairment represents a significant concern within the spectrum of post-acute sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, particularly impacting the aging popu...
An open-source pipeline for longitudinal single-cell tracking and cell-cycle/migration coupling analysis for neurotherapeutic screening [0.03%]
一种用于纵向单细胞追踪及细胞周期/迁移耦合分析的开源管线以供神经治疗筛选使用
Neha Chandra,Matthew Yang,Hailey Wang et al.
Neha Chandra et al.
Background: Imaging-based phenotypic assays are widely used in neuroprotection, drug discovery, and neurorepair studies, but long-term, high-throughput time-lapse datasets remain difficult to analyze because of segmentati...
Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease [0.03%]
帕金森病不同症状期的脑萎缩影像学模式及遗传关联研究
Yi Ji,Liujia Lu,Kaidong Chen et al.
Yi Ji et al.
Background: Parkinson's disease (PD) involves progressive gray matter (GM) atrophy, but stage-specific imaging patterns and their genetic mechanisms remain unclear. This study aimed to characterize GM atrophy across PD st...
Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post-stroke neurorepair [0.03%]
肝素硫酸盐和糖类制剂：中风后神经修复的合成及生物应用新进展
Mozammel H Bhuiyan,Madeleine J Smith,Simon F R Hinkley et al.
Mozammel H Bhuiyan et al.
Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and neuroprotection. The ability of heparan sulf...
Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications [0.03%]
阿尔茨海默病的昼夜节律和时间治疗：机制和治疗意义
Bivek Singh,Filippo Pigazzani,Roberto Manfredini
Bivek Singh
Alzheimer's disease (AD), the most prevalent form of dementia, has been increasingly associated with disruptions in circadian rhythms and sleep-wake regulation. This narrative review synthesizes recent literature on how circadian dysfunctio...