Decoding the role of large heat shock proteins in the progression of neuroinflammation-mediated neurodegenerative disorders [0.03%]
解读大型热休克蛋白在神经炎症介导的神经退行性疾病进展中的作用
Shailendra K Saxena,Deepak Sharma,Swatantra Kumar et al.
Shailendra K Saxena et al.
Chronic neuroinflammation and protein aggregation are the fundamental events mainly responsible for the progression of neurodegenerative diseases (NDs). Potential neurotoxic changes in the intra- and extracellular environment are typical ha...
Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms [0.03%]
经颅磁刺激对阿尔茨海默病的神经保护作用：尚待确定的治疗方案及机制
Yang Zhu,Lingyi Liao,Shihao Gao et al.
Yang Zhu et al.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions, for which an effective treatment is currently unavailable. Repetitive transcranial magnetic stimulation (rTMS)...
Mechanisms of glutamate metabolic function and dysfunction in vascular dementia [0.03%]
血管性痴呆中谷氨酸代谢的功能与异常机制
Jiawen Wang,Yingmei Zhang,Ning Tian et al.
Jiawen Wang et al.
As the global population ages, research on the pathogenesis and treatment options for older patients with dementia has become increasingly important. Vascular dementia (VaD), the second most frequent type of dementia, is characterized by va...
The dual role of microglia in ischemic stroke and its modulation via extracellular vesicles and stem cells [0.03%]
微胶质细胞在缺血性脑卒中中的双刃剑作用及其通过外泌体和干细胞进行的调控作用
Matteo Haupt,Stefan T Gerner,Thorsten R Doeppner
Matteo Haupt
Stem cell-based therapies and extracellular vesicle (EV) treatment have demonstrated significant potential for neuroprotection against ischemic stroke. Although the neuroprotective mechanisms are not yet fully understood, targeting microgli...
Role of autoreactive Tc17 cells in the pathogenesis of experimental autoimmune encephalomyelitis [0.03%]
自身反应性Tc17细胞在实验性自体免疫性脑脊髓炎发病机制中的作用
Yong Peng,Xiuli Zhang,Yandan Tang et al.
Yong Peng et al.
Background: The pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE-an animal model of MS) is primarily mediated by T cells. However, recent studies have only focused on interleukin ...
Kirby E Warren,Rebecca J Hood,Fredrick R Walker et al.
Kirby E Warren et al.
Background: It has long been assumed that post-stroke intracranial pressure (ICP) elevation occurs because of large infarct and edema volumes. However, we have repeatedly shown ICP elevation at 24 h post-stroke in the pre...
Recent advances in therapeutic strategies for Alzheimer's and Parkinson's disease using protein/peptide co-modified polymer nanoparticles [0.03%]
用于治疗阿尔茨海默病和帕金森病的蛋白质/肽共修饰聚合物纳米粒子的最新进展
Ramesha Hanumanthappa,Aravind Parthasarathy,Geetha B Heggannavar et al.
Ramesha Hanumanthappa et al.
The blood-brain barrier (BBB), which protects the brain from foreign molecules, makes delivery of drugs to the central nervous system is challenging. Nanoparticles (NPs) have been used over the past decade as drug delivery systems for the t...
A multicenter single-arm objective performance criteria trial evaluating the efficacy and safety of a dedicated venous sinus thrombectomy device for severe cerebral venous sinus thrombosis [0.03%]
一项多中心单臂客观疗效指标试验评估专用静脉窦取栓装置治疗重度颅内静脉窦血栓的有效性和安全性
Shadamu Yusuying,Yan Wu,Ming Li et al.
Shadamu Yusuying et al.
Aim: Approximately 21% of patients with cerebral venous sinus thrombosis (CVST) are refractory to anticoagulation treatment and face poor prognosis. These patients may benefit from endovascular therapy. Although numerous ...
A novel perspective in stroke neuroprotection: Leveraging hypoxic pocket insights for studying preconditioning and postconditioning [0.03%]
一种新的卒中神经保护视角：利用低氧区的认识研究缺血前适应和缺血后处理
Heng Zhao,Yan Meng,Sijie Li et al.
Heng Zhao et al.
This perspective article delineates the significant role of hypoxic pockets-localized, transient reductions in cerebral oxygenation-and their implications for stroke neuroprotection strategies. It posits that preconditioning and postconditi...
Mass spectrometry-based proteomics for biomarker discovery in the Drosophila model of Parkinson's disease [0.03%]
基于质谱的蛋白质组学在果蝇帕金森模型中的生物标志物发现研究
Mohammad Radid Khan,Ramisha A Rahman,Md Harunur Rashid et al.
Mohammad Radid Khan et al.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Despite extensive research, the etiology of both familial and sporadic PD remains unclear. While most PD cases are sporadic, a significant minority ...