Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease [0.03%]
从胰岛β细胞到脑细胞：胰岛素和糖代谢在阿尔茨海默病中的关键作用
Stanley S Schwartz,Elizabeth M Rhea,William A Banks et al.
Stanley S Schwartz et al.
The risk factors and neuropathologies of cognitive decline and the onset and progression of dementia-related disorders were, until recently, obtuse. A critical predisposing factor to Alzheimer's disease (AD) that has emerged is glucose dysm...
Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta-analysis [0.03%]
预防早产儿脑室内出血的维生素E治疗：系统评价和 Meta 分析
Felipe Araujo Gouhie,Ana Clara Nogueira Cezar,Davi Alves Silva et al.
Felipe Araujo Gouhie et al.
Background: Some research suggests that vitamin E may help prevent intraventricular hemorrhage (IVH) in preterm neonates. However, consolidated evidence regarding its effects on brain vascular health in this population is...
Shen Li,Piotr Walczak,Xunming Ji et al.
Shen Li et al.
Activation of dopamine 2 receptors modulates glutamate decarboxylases 65 and 67 during stroke recovery in mice [0.03%]
多巴胺2型受体激活通过调节谷氨酸脱羧酶65和67促进小鼠卒中恢复
Daniela Talhada,Robert Nilsson,Severin Walser et al.
Daniela Talhada et al.
Backgrounds: Treatment with levodopa enhances recovery of lost neurological functions in preclinical stroke models and patients. Here, we studied whether dopamine signaling modulates GABAergic neurotransmission in parvalb...
The potential of a combined cell-based therapy and rehabilitation approach for stroke recovery [0.03%]
细胞治疗与康复结合促进卒中恢复的潜力
Abdulhameed Bakreen,Jukka Jolkkonen
Abdulhameed Bakreen
Activation of neuroprotective and particularly later neurorestorative mechanisms after stroke attempts to restore or compensate for lost functions. This potentially opens a wide window for restorative therapies to promote brain repair and i...
Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID [0.03%]
与炎症谱型相关、伴有颈静脉血栓的神经系统症状可能是长新冠的后遗症
Elizabeth Mendoza-Portillo,Estefania Aleman-Navarro,G Aleph Prieto et al.
Elizabeth Mendoza-Portillo et al.
More than 670 million cases of coronavirus disease 2019 (COVID-19) have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. About 45% of survivors of COVID-19 ...
Beyond boundaries: Neuroprotective effects of steroids and ecdysteroids in SH-SY5Y cells - A systematic review [0.03%]
跨越界限：皮质类固醇和虫甾体在SH-SY5Y细胞中的神经保护作用——一项系统性综述
Bizhar Ahmed Tayeb,Isaac Kinyua Njangiru,Renáta Minorics
Bizhar Ahmed Tayeb
Steroids and ecdysteroids have been shown to exhibit a range of biological effects, including anti-inflammatory, anticancer, and neuroprotective. This systematic review aims to highlight the evidence-based neuroprotective and antioxidant ef...
Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus [0.03%]
应激增强大鼠海马钙结合蛋白和N-甲基-D-天冬氨酸受体亚单位基因的表达
Aravind Parthasarathy,Ramesha Hanumanthappa,Sarojini R Bulbule et al.
Aravind Parthasarathy et al.
Backgrounds: Oxidative stress impairs the function of calcium-binding proteins and deregulates calcium signaling in living organisms. We have previously explored the overexpression of calcium-binding protein genes in a re...
Targeting brain-derived neurotrophic factor in the treatment of neurodegenerative diseases: A review [0.03%]
靶向脑源性神经营养因子治疗神经退行性疾病：综述
Dong Wang,Zhi-Chen Lang,Shi-Nan Wei et al.
Dong Wang et al.
Neurodegenerative diseases, marked by the gradual death of neurons, present a significant and growing public health challenge. Brain-derived neurotrophic factor (BDNF) is crucial for the survival, development, and synaptic plasticity of neu...
The role of angiotensin II type 1 receptor pathway in cerebral ischemia‒reperfusion injury: Implications for the neuroprotective effect of ARBs [0.03%]
血管紧张素Ⅱ受体介导的信号转导通路在脑缺血再灌注损伤中的作用及血管紧张素Ⅱ受体拮抗剂的神经保护效应研究进展
Shuhan Huang,Meng Zhang
Shuhan Huang
Cerebral ischemia-reperfusion (I/R) injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke (AIS). It has been found that the brain renin-angiotensin system, especially the angiotensin II ty...