Better understanding complex pathomechanisms in central nervous system disorders as a prerequisite for improved diagnostic and therapeutic approaches [0.03%]
阐明中枢神经系统疾病的复杂发病机制以改善诊断和治疗手段
Piotr Walczak,Shen Li,Xunming Ji et al.
Piotr Walczak et al.
Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives [0.03%]
线粒体转移在缺血性脑卒中治疗中的新作用机制及其面临的挑战和未来前景
Shuchen Meng,Min Bai,Changsheng Ma et al.
Shuchen Meng et al.
Ischemic stroke, the second leading cause of human mortality, presents a formidable challenge to healthcare. Following ischemic insult, the brain undergoes intricate pathological transformations, prominently marked by mitochondrial damage, ...
Huihui Jiang,Haitao Wu
Huihui Jiang
Liquid-liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane-less condensates. In the nervous system, the formation of distinct molecular condensates via phase sepa...
Monocytes in neonatal stroke and hypoxic-ischemic encephalopathy: Pathophysiological mechanisms and therapeutic possibilities [0.03%]
新生儿卒中和缺氧缺血性脑病中的单核细胞：病理生理机制及治疗潜力
Pedro M Pimentel-Coelho
Pedro M Pimentel-Coelho
Neonatal arterial ischemic stroke (NAIS) and neonatal hypoxic-ischemic encephalopathy (HIE) are common causes of neurological impairments in infants, for which treatment options are very limited. NAIS and HIE induce an innate immune respons...
Aishika Datta,Bijoyani Ghosh,Deepaneeta Sarmah et al.
Aishika Datta et al.
Stroke is devastating and the second leading cause of disability and death worldwide. The pathophysiology of stroke is intricate involving oxidative stress, ionic imbalance, and excitotoxicity leading to cell death. The current therapeutic ...
Five percent CO2 inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats [0.03%]
5%二氧化碳吸入缓解睡眠剥夺大鼠海马谷氨酸及水代谢紊乱、神经元损伤和学习记忆障碍
Zhihong Zhao,Xiaojun Zhang,Xiaolei Zhang et al.
Zhihong Zhao et al.
Background: Sleep deprivation causes hippocampal injury, manifesting as neuronal damage and learning-memory impairment. These negative effects may be associated with disturbance of hippocampal glutamate and water homeosta...
Impact of neutrophil-to-lymphocyte ratio on the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy [0.03%]
中性粒细胞与淋巴细胞计数比值对急性缺血性卒中介入取栓术后临床转归的影响：来自中国多中心的证据
Tao Tang,Dawei Zhang,Fang Wang et al.
Tao Tang et al.
Background: The neutrophil-to-lymphocyte ratio (NLR) is highly associated with stress responses to acute disorders and may be useful for differentiating hyperglycemia after stroke that is induced by stress or other causes...
Interleukin-6 induces cognitive impairment via toll-like receptor 4 (TLR4)-mediated neuroinflammation and neurodegeneration in mice with chronic kidney disease [0.03%]
白细胞介素-6通过 Toll 样受体 4（TLR4）诱导慢性肾脏病小鼠神经炎症和神经变性导致认知障碍
Yangping Shentu,Shuqing Ma,Simin Ye et al.
Yangping Shentu et al.
Backgrounds: Past epidemiological and experimental studies in rodents have demonstrated that chronic kidney disease (CKD) leads to cognitive impairment. However, the underlying mechanism requires further investigation. He...
Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress-regulated neuronal apoptosis in APP/PS1 transgenic mice [0.03%]
下调叉头框O1乙酰化水平通过抑制内质网应激介导的神经元凋亡改善APP/PS1转基因小鼠认知功能损伤
Nan Zhang,Zongyuan Zhao,Xiaoxiao Chen et al.
Nan Zhang et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system. Silent information regulator sirtuin 1 (SIRT1) may deacetylate and suppress forkhead box O (FOXO) activities to...
Lingjie Mu,Yijie Wang
Lingjie Mu
Neuroinflammation, a key defense mechanism of the nervous system, is associated with changes in inflammatory markers and stimulation of neuroimmune cells such as microglia and astrocytes. Growing evidence indicates that the gut microbiota a...