Environmental enrichment modulates chronic poststroke inflammation and links white matter TREM2-positive microglia in recovery in mice [0.03%]
环境丰富通过调节慢性中风后的炎症并连接白质中的TREM2阳性小胶质细胞来促进小鼠恢复
Lluís Camprubí-Ferrer,Ömer K Kolbay,Miriana J Quattromani et al.
Lluís Camprubí-Ferrer et al.
Background: Environmental enrichment (EE) has been widely reported to improve functional recovery after stroke, yet its effects on chronic inflammation and white matter pathology remain less well defined. The aim of this ...
Regulatory B cells in the central nervous system: From immune regulation to neuroprotection [0.03%]
中枢神经系统中的调节性B细胞：从免疫调控到神经保护
Luiza Stanaszek,Miroslaw Janowski
Luiza Stanaszek
This review examines the immunoregulatory functions of interleukin-10 (IL-10)-secreting regulatory B cells (Bregs), specifically focusing on their potential neuroprotective roles and therapeutic implications for central nervous system (CNS)...
Rehabilitation paired with vagus nerve stimulation for motor function of chronic ischemic stroke patients in China: Study protocol of a multicenter randomized controlled trial (Repair Study) [0.03%]
中国慢性缺血性卒中患者运动功能康复联合迷走神经刺激治疗的多中心随机对照试验方案（RePAIR研究）
Anchao Yang,Yong Liu,Hongxing Huang et al.
Anchao Yang et al.
Background: Stroke remains the leading cause of long-term disability worldwide. Approximately 60% of individuals with chronic ischemic stroke experience persistent upper limb impairment that limits daily activities. The R...
Cerebral in situ ischemic postconditioning: From bench to bedside and beyond [0.03%]
脑原位缺血后处理：从实验室到临床及未来的展望
Xiao Jiang,Wenbo Zhao,Yongbo Xu et al.
Xiao Jiang et al.
Ischemic postconditioning (IPostC) has emerged as a promising therapeutic strategy for mitigating ischemia-reperfusion injury in ischemic tissues. However, its neuroprotective potential following thrombectomy in acute ischemic stroke (AIS) ...
Re-conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention [0.03%]
从终生神经生物学轨迹的角度重新定义帕金森病：预防框架
Ayodeji Johnson Ajibare,Abraham Olufemi Asuku,Olabode Oluwadare Akintoye
Ayodeji Johnson Ajibare
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. No disease-modifying therapies exist. This review proposes that PD susceptibility begins with epigenetic changes and neuroimmune activity-factors that alter gene...
New insights into disease-modifying factors and clinical translation for central nervous system diseases [0.03%]
中枢神经系统疾病的修饰因素和临床转化的全新认识
Shen Li,Xunming Ji,Piotr Walczak et al.
Shen Li et al.
Rapid eye movement sleep deprivation induced gene regulation for modulation of noradrenaline level in brain regions of rats: Implications with chronic sleep-loss associated pathophysiological conditions [0.03%]
快速眼动睡眠剥夺诱导大鼠脑区noradrenaline水平变化的基因调节：慢性睡眠丢失相关病理生理状态的含义研究
Rachna Mehta,Raghavendra Murali,Birendra Nath Mallick
Rachna Mehta
Background: Rapid eye movement sleep (REMS) loss affects almost all physiological processes, while it itself is affected in disorders. REMS maintains optimum level of noradrenaline (NA) in a healthy individual, while incr...
Chao Jiang,Jingying Ma,Jingyu Mu et al.
Chao Jiang et al.
Compelling evidence indicates a significant connection between dysfunction of the gastrointestinal tract, the gut microbiome, and Parkinson's disease (PD), which aligns with the notion of the "gut-brain axis". While the exact mechanisms inv...
Acute hemichorea-hemiballism as the initial sign of cortical cerebral infarction: A case report [0.03%]
基底节区脑梗死出现偏侧舞蹈样动作的临床表现：1例报告
Jin Xiong,Qian Yang,Yong Liu et al.
Jin Xiong et al.
Hemichorea-hemiballism is classically associated with the contralateral basal ganglia, particularly involving the putamen and subthalamic nucleus, whereas cortical involvement remains a rare etiology. In this case, we present a patient with...
Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking [0.03%]
网络毒理学和分子对接有效分析异氟醚对术后谵妄的毒性及机制研究
Zhiming Dai,Qing Nan,Menglu Xu et al.
Zhiming Dai et al.
Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remain...