Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease [0.03%]
熊去氧胆酸在帕金森病和阿尔茨海默病中的神经保护作用
Ashley En Yi Chong,Andrew Octavian Sasmita,Rhun Yian Koh et al.
Ashley En Yi Chong et al.
Neurodegenerative diseases (NDDs) including Parkinson's disease (PD) and Alzheimer's disease (AD), are progressive disorders characterised by shared pathological features, including mitochondrial dysfunction, oxidative stress, apoptosis, ne...
Exercise, exerkines, and muscle-brain crosstalk in Parkinson's disease [0.03%]
运动、运动激素和帕金森病中的肌肉-大脑对话
Salomón Páez-García,Edgar Alvarado,Alejandro Cuevas et al.
Salomón Páez-García et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms, driven by dopaminergic loss and α-synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health ...
Post-recanalization administration of rapamycin improves functional outcome and reduces infarct size in a rat model of ischemic stroke [0.03%]
雷帕霉素在缺血性脑卒中后的再疏通中的应用可改善大鼠的功能预后并减少梗死面积
Anna M Schneider,Yvonne Couch,James Larkin et al.
Anna M Schneider et al.
Aim: Despite advances in endovascular recanalization for ischemic stroke, many patients experience poor outcomes. Adjunct cerebroprotective therapies are needed to improve recovery. The mammalian target of rapamycin compl...
Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery [0.03%]
缺血性脑卒中后芳香化酶的表达增加及其对神经保护和功能恢复的影响
Lindsay Gallagher,Anna F Dominiczak,Luis M Garcia-Segura et al.
Lindsay Gallagher et al.
Aim: Aromatase is the key enzyme in the biosynthesis of 17β-estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variant...
Research status and trends of Piezo1 and brain: A bibliometric analysis [0.03%]
Piezo1与脑的研究现状及趋势：基于文献计量的分析研究
Yu Liu,Shengzhen Luo,Hao Zhang et al.
Yu Liu et al.
Aim: As a key mechanosensitive ion channel, Piezo1 plays a critical role in various brain functions, including the regulation of cerebral blood flow and neuronal excitability, by converting mechanical stimuli into biochem...
Comment on "Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta-analysis" [0.03%]
关于“极低出生体重儿脑室内出血维生素E预防效果的系统评价和Meta分析”的评论
Prashant R Kokiwar,Ambreen S Chauhan,A Kavya et al.
Prashant R Kokiwar et al.
Bee venom enhances dopaminergic function and behavioral recovery in a murine model of Parkinson's disease [0.03%]
蜜蜂毒液可改善帕金森病小鼠模型的多巴胺能功能和行为恢复能力
Silvia Josefina López-Pérez,Marco Antonio Noriega-Ruiz,Alma Karen Lomeli-Lepe
Silvia Josefina López-Pérez
Background: Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons, leading to motor dysfunction and cognitive impairment. Although levodopa (l-DOPA)/carbidopa remains the gold stand...
Novel approaches for neuroprotection: Focus on neurodegenerative and ischemic central nervous system diseases [0.03%]
神经保护的新方法——针对神经退行性和缺血性中枢神经系统疾病
Shen Li,Xunming Ji,Piotr Walczak et al.
Shen Li et al.
Depletion of microglial compensation in glial network: Disease-associated response dynamics in the revised amyloid hypothesis [0.03%]
微胶质细胞代偿耗尽：修正版淀粉样蛋白假说下的神经胶质网络疾病相关反应动力学
Songtao Lei,Zixuan Huang,Wen Wang et al.
Songtao Lei et al.
Microglia mount coordinated, stage-dependent compensatory programs in response to early amyloid β (Aβ) accumulation that preserve proteostasis and neuronal integrity during preclinical Alzheimer's disease. We propose the "microglial compe...
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders [0.03%]
胆固醇迷宫中的导航：关于他汀类药物在神经退行性疾病中使用的关键见解
Jun Han Kuan,Roshan S Raghavan,Dawn Li Wei Koh et al.
Jun Han Kuan et al.
Neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), Huntington's (HD), and multiple sclerosis (MS) involve progressive neuronal loss driven by dysregulated neurotransmission, neuroinflammation, oxidative stress, and mitoc...