Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations [0.03%]
两个端对端的猪基因组组装和泛基因组分析提供了关于基因组结构景观和遗传适应性的见解
Wencheng Zong,Li Chen,Dongjie Zhang et al.
Wencheng Zong et al.
This study presented two high-precision telomere-to-telomere genome assemblies for Min and Rongchang pigs, including a detailed exploration of the telomeric and centromeric regions. By integrating pan-genome and multi-omics analyses, struct...
iMLGAM: Integrated Machine Learning and Genetic Algorithm-driven Multiomics analysis for pan-cancer immunotherapy response prediction [0.03%]
基于机器学习和遗传算法驱动的多组学泛癌免疫治疗反应预测集成分析(iMLGAM)
Bicheng Ye,Jun Fan,Lei Xue et al.
Bicheng Ye et al.
To address the substantial variability in immune checkpoint blockade (ICB) therapy effectiveness, we developed an innovative R package called integrated Machine Learning and Genetic Algorithm-driven Multiomics analysis (iMLGAM), which estab...
MDIPID: Microbiota-drug interaction and disease phenotype interrelation database [0.03%]
MDIPID数据库：微生物-药物相互作用及与疾病表型相互关系数据库
Jiayi Yin,Hui Ma,Yuting Qi et al.
Jiayi Yin et al.
The intricate bidirectional relationships among microbiota, microbial proteins, drugs, and diseases are essential for advancing precision medicine and minimizing adverse drug reactions. However, there are currently no data resources that co...
Phenotyping, genome-wide dissection, and prediction of maize root architecture for temperate adaptability [0.03%]
适用于温带环境的玉米根系结构的表型鉴定、基因组分析及预测能力
Weijun Guo,Fanhua Wang,Jianyue Lv et al.
Weijun Guo et al.
Root System Architecture (RSA) plays an essential role in influencing maize yield by enhancing anchorage and nutrient uptake. Analyzing maize RSA dynamics holds potential for ideotype-based breeding and prediction, given the limited underst...
Gut microbiota in cancer: From molecular mechanisms to precision medicine applications [0.03%]
肠道微生物群与癌症：从分子机制到精准医学应用
Weihua Xiao,Qiong Chen,Chunjiao Liu et al.
Weihua Xiao et al.
The gut microbiota-cancer interaction functions through multi-level biological mechanisms, forming the basis for both diagnostic and therapeutic applications. Current technical and biological challenges drive the field toward precision medi...
New insights into genome assembly at the chromosome-level of Prunus tomentosa in evolution and cold tolerance [0.03%]
进化和耐寒性视角下的毛桃染色体水平基因组组装新见解
Songtao Jiu,Muhammad Aamir Manzoor,Zhengxin Lv et al.
Songtao Jiu et al.
This study assembled a high-quality chromosome-level genome of Prunus tomentosa, offering a vital resource for elucidating its genetic architecture, evolutionary relationships, and facilitating genome-assisted breeding efforts. Multi-omics ...
HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota [0.03%]
肠菌衍生的外泌体通过肠道微生物群来源的细胞外囊泡调控HLF和PPARα轴调节与代谢相关脂肪性肝病
Xingzhen Yang,Jiale Wang,Xinyu Qi et al.
Xingzhen Yang et al.
Metabolic-associated fatty liver disease (MAFLD) has become increasingly widespread. The intestine is the primary site of lipid absorption and is important for the homeostasis of lipid metabolism. However, the mechanism underlying the parti...
Enhancement of gut barrier integrity by a Bacillus subtilis secreted metabolite through the GADD45A-Wnt/β-catenin pathway [0.03%]
枯草芽孢杆菌分泌代谢产物通过GADD45A-Wnt/β-连环蛋白信号通路增强肠道屏障功能
Shiqi Liu,Peiran Cai,Wenjing You et al.
Shiqi Liu et al.
Inflammatory bowel disease (IBD) represents a significant challenge to global health, characterized by intestinal inflammation, impaired barrier function, and dysbiosis, with limited therapeutic options. In this study, we isolated a novel s...
T2T genome, pan-genome analysis, and heat stress response genes in Rhododendron species [0.03%]
绣球花基因组、泛基因组分析及热响应基因研究
Xiaojing Wang,Ping Zhou,Xiaoyu Hu et al.
Xiaojing Wang et al.
This study reports the first high-quality telomere-to-telomere (T2T) Rhododendron liliiflorum genome with 11 chromosomes that are gap free. The 24 telomeres and all 13 centromeres detected in this genome, which reached the highest quality g...
Transmission of antimicrobial resistance genes from the environment to human gut is more pronounced in colorectal cancer patients than in healthy subjects [0.03%]
肠道抗微生物药物耐药基因从环境传播到人类结直肠癌患者比健康人更显著
Weixin Liu,Harry C H Lau,Xiao Ding et al.
Weixin Liu et al.
Antimicrobial resistance is a major global health concern. However, the source of gut resistome remains unsolved. We aimed to analyze the contribution of environmental antimicrobial resistance genes (ARGs) to colorectal cancer (CRC) patient...