Spinal cord injury induces acute microbiome shock and system-wide transcriptomic reprogramming [0.03%]
脊髓损伤引起急性菌群紊乱和全身转录组重塑
Chi Zhang,Yufei Du,Mingxin Wu et al.
Chi Zhang et al.
This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rapid and severe disruption of the gut micro...
Chondroitin sulfate restores muscle mass via gut-muscle axis remodeling through sugar-bile acid metabolism reprogramming [0.03%]
Ruiyun Wu,Tao Wen,Nan Shang et al.
Ruiyun Wu et al.
Glucocorticoid-induced myopathy is characterized by progressive muscle atrophy and impaired regeneration, yet effective microbiota-oriented interventions for preserving muscle homeostasis remain largely unexplored. Here, we demonstrate that...
A large-scale single-cell transcriptomic atlas indicates the immune panorama of influenza A infection [0.03%]
大规模单细胞转录组绘制揭示了甲型流感病毒感染的免疫全景图
Yi Wang,Shuzi Liu,Laurence Don Wai Luu et al.
Yi Wang et al.
Influenza A virus (IAV) infection has a wide clinical spectrum, from mild illness to life-threatening pneumonia, yet the underlying immune determinants of disease remain poorly defined. Here, we generated a large-scale single-cell transcrip...
Accu16S/AccuITS: Accurate and broadly applicable amplicon sequencing for absolute microbiome quantification [0.03%]
精准且通用的扩增子测序法实现绝对定量微生物组分析-Acu16S/AcuITS
Defeng Bai,Ou Fang,Caihua Li et al.
Defeng Bai et al.
Traditional 16S rRNA gene and Internal Transcribed Spacer region amplicon sequencing provides only relative abundance, often leading to biased ecological interpretations. To overcome this limitation, we developed Accu16S/AccuITS, an absolut...
Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells [0.03%]
染色质解链状态可原位鉴定并追踪循环肿瘤细胞
Bin Ye,Zhen Wang,Yinqi Bai et al.
Bin Ye et al.
The detection of circulating tumor cells (CTCs) through liquid biopsy offers a non-invasive approach for accurately monitoring cancer dissemination and evaluating therapeutic efficiency. However, their rarity and heterogeneity limit convent...
Two stable gut microbiome guilds predict liver tumor class and treatment responses [0.03%]
两个稳定的肠道微生物组联盟预测肝肿瘤分类和治疗反应
Yang Liu,Zefan Zhang,Guojun Wu et al.
Yang Liu et al.
Gut microbiome alterations are increasingly associated with hepatocellular carcinoma (HCC), highlighting the gut-liver axis as a key contributor to tumor progression and prognosis. Taxon-based HCC microbiome studies have shown limited repro...
Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers [0.03%]
靶向DGKα/PA轴可抑制胃肠道肿瘤的免疫逃逸并增强其对免疫治疗的敏感性
Jie Chen,Siqi Liu,Ting Peng et al.
Jie Chen et al.
Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signaling pathways in local tumor tissues. Here...
Microbial synthetic community ARC prevents aflatoxin and increases rhizobia-legume nodulation couplingly [0.03%]
微生物合成社区ARC联合防止黄曲霉素和增加根瘤菌-豆类结节耦合生成
Qi Zhang,Tao Wang,Xiaoqian Tang et al.
Qi Zhang et al.
Develop a novel strategy for exploring a dual-functional microbial synthetic community. Invent the SynCom ARC, which achieves aflatoxin control and rhizobia nodulation induction coupling in peanut. SynCom ARC inhibits A. flavus growth and r...
Intratumoral Enterobacter hormaechei drives gemcitabine resistance in pancreatic cancer via cdd L-mediated drug inactivation [0.03%]
胰腺癌肿瘤内的阴沟肠杆菌通过cdt L介导的药物失活驱动吉西他滨耐药性
Jun-Feng Peng,Meixia Li,Ting Niu et al.
Jun-Feng Peng et al.
Gemcitabine resistance poses a critical barrier to improving survival in pancreatic cancer, yet the microbial drivers remain elusive. By integrating 16S rRNA amplicon sequencing with large-scale culturomics across 114 clinical samples, we i...
Single-cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection [0.03%]
Liang Shao,Fan Hu,Ling-Na Zhao et al.
Liang Shao et al.
We utilized single-cell RNA sequencing (scRNA-seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) sub...