Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example [0.03%]
基于核心酶结构的微生物组功能调控研究——以脲酶为例
Shengguo Zhao,Huiyue Zhong,Yue He et al.
Shengguo Zhao et al.
Microbial communities play critical roles in various ecosystems. Despite extensive research on the taxonomic and functional diversity of microbial communities, effective approaches to regulate targeted microbial functions remain limited. He...
Single-microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut [0.03%]
单微生物RNA测序揭示人类肠道驱动物种的代谢功能
Yifei Shen,Wenxin Qu,Mengdi Song et al.
Yifei Shen et al.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, but it is still mainly...
Xiangyu Li,Ying Wu,Bin Yi et al.
Xiangyu Li et al.
The Western China Birth Cohort (WCBC) is a large-scale, multi-centered, prospective birth cohort study designed to address critical gaps in maternal and child health research in Western China, a region with diverse altitudes, ethnic groups,...
Yuan Sun,Sai Liu,Long Chen et al.
Yuan Sun et al.
Spaceflight reshapes microbiota and immune function, mitigating some ageing effects while accelerating immune aging, revealing crucial insights for astronaut health and longevity in space missions. ...
Tim Van Den Bossche,Jean Armengaud,Dirk Benndorf et al.
Tim Van Den Bossche et al.
Metaproteomics is an emerging approach for studying microbiomes, offering the ability to characterize proteins that underpin microbial functionality within diverse ecosystems. As the primary catalytic and structural components of microbiome...
Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48-ADC) combined immunotherapy in patients with muscle-invasive bladder cancer: A multi-center real-world study [0.03%]
国产新药RC48-ADC新辅助治疗肌层浸润性膀胱尿路上皮癌的疗效及生物标志物分析：多中心真实世界研究
Jiao Hu,Luzhe Yan,Jinhui Liu et al.
Jiao Hu et al.
In this study, 102 cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC) who received neoadjuvant RC48-ADC combined with immunotherapy were included. We evaluated the pathological responses and explored multiple clinical ...
Specificity landscapes of 40 R2R3-MYBs reveal how paralogs target different cis-elements by homodimeric binding [0.03%]
40个R2R3-MYB的特异性图谱揭示了旁系同源物通过同二聚体结合作用于不同的顺式元件
Tian Li,Hao Chen,Nana Ma et al.
Tian Li et al.
Paralogous transcription factors (TFs) frequently recognize highly similar DNA motifs. Homodimerization can help distinguish them according to their different dimeric configurations. Here, by studying R2R3-MYB TFs, we show that homodimeriza...
Time-restricted feeding mitigates Alzheimer's disease-associated cognitive impairments via a B. pseudolongum-propionic acid-FFAR3 axis [0.03%]
时间限制性进食通过Bacteroides pseudolongum-丙酸盐-FFAR3轴减轻阿尔茨海默病相关认知障碍
Yihang Zhao,Mengzhen Jia,Chen Ding et al.
Yihang Zhao et al.
Time-restricted feeding (TRF) holds promise for alleviating cognitive decline in aging, albeit the precise mechanism via the gut-brain axis remains elusive. In a clinical trial, we observed, for the first time, that a 4-month TRF ameliorate...
Tidyplots empowers life scientists with easy code-based data visualization [0.03%]
tidyplots使生命科学家能够轻松地进行基于代码的数据可视化
Jan Broder Engler
Jan Broder Engler
Code-based data visualization is a crucial tool for understanding and communicating experimental findings while ensuring scalability and reproducibility. However, complex programming interfaces pose a significant barrier for life scientists...
Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations [0.03%]
在华人前列腺癌队列中鉴定嵌合RNA的表达并揭示其与西方人群间的异同点
Qiong Wang,Shunli Yu,Jirong Jie et al.
Qiong Wang et al.
Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans-splicing and cis-splicing between adjacent genes are also shown to generate chimeric RNAs. They...