Age-specific reference intervals for plasma amino acids and their associations with nutrient intake in the Chinese pediatric population [0.03%]
中国儿童血浆氨基酸年龄参考区间及其与营养素摄入的关系
Yang Wen,Qing Liu,Hongbo Zeng et al.
Yang Wen et al.
A total of 2901 healthy Chinese children aged 0-12 years were enrolled in the reference group; 102 confirmed Phenylketonuria cases were included as validation individuals. Establishing the age-specific reference intervals of 42 plasma amino...
Integrative cross-tissue analysis unveils complement-immunoglobulin augmentation and dysbiosis-related fatty acid metabolic remodeling during mammalian aging [0.03%]
整合的跨组织分析揭示了哺乳动物衰老期间补体-免疫球蛋白增强和与菌群失调相关的脂肪酸代谢重塑
Feng Zhang,Rong Li,Yasong Liu et al.
Feng Zhang et al.
Aging-related decline and adaptation are complex, multifaceted processes that affect various tissues and increase risk of chronic diseases. To characterize key changes in cross-tissue aging, we performed comprehensive proteomic and metabolo...
Comprehensive analysis of multi-omics single-cell data using the single-cell analyst [0.03%]
使用单细胞分析工具对多组学单细胞数据进行综合分析
Lu Pan,Bufu Tang,Xuan Zhang et al.
Lu Pan et al.
The rapid advancement of multi-omics single-cell technologies has significantly enhanced our ability to investigate complex biological systems at unprecedented resolution. However, many existing analysis tools are complex, requiring substan...
Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation [0.03%]
番红花素通过调节CD4+T细胞分化介导肠道微生物群衍生丁酸的抗结肠炎效应
Yunqi Xing,Muyuan Wang,Yali Yuan et al.
Yunqi Xing et al.
This study explored the effect of plant-derived indigo supplementation on intestinal inflammation using in vivo, in vitro, and clinical sample analyses. Our results showed that indigo decreased mucosal inflammation by regulating CD4+ T cell...
Rashidin Abdugheni,Shuang-Jiang Liu
Rashidin Abdugheni
Prokaryotic taxonomy based on short 16S rRNA sequences may lead to an overestimation of microbial diversity. In addition, a lack of sufficient coverage of previously reported taxa may lead to repetition or overestimation of novel taxa. In l...
Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan-related metabolites for health longevity in centenarians [0.03%]
血清代谢和微生物组特征分析揭示了色氨酸衍生物促进百岁老人健康长寿的作用机制
Xiaorou Qiu,Chao Mu,Jie Hu et al.
Xiaorou Qiu et al.
A better understanding of the characteristic serum metabolites and microbiota from the gut and oral cavity in centenarians could contribute to elucidating the mutual connections among them and would help provide information to achieve healt...
Reda El Boukhari,Maima Matin,Latifa Bouissane et al.
Reda El Boukhari et al.
The microbiota, comprising all the microorganisms within the body, plays a critical role in maintaining good health. Dysbiosis represents a condition resulting from an imbalance or alteration of the microbiota. This study comprehensively in...
Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress-mediated Notch signaling [0.03%]
丁酸通过抑制氧化应激介导的诺特定理信号改善肠道屏障完整性从而缓解食物过敏
Jialu Shi,Wenjun Mao,Yuqing Song et al.
Jialu Shi et al.
Food allergy (FA) has received increased attention in recent years. Multiple studies have highlighted the crucial role of short-chain fatty acids (SCFAs) in the development of IgE-mediated FA. Here, a case-control approach was employed to a...
Agriculture increases potential health risks of vertebrate viruses in soils [0.03%]
农业增加了土壤中脊椎动物病毒的潜在健康风险
Kankan Zhao,Yiling Wang,Ran Xue et al.
Kankan Zhao et al.
Here, we conducted a large-scale investigation of vertebrate viruses in soils and found soil was a mediator of vertebrate viruses. Compared to natural soils, agricultural soils possessed distinct prevalence patterns, with a higher detection...
Peripheral blood immune landscape and NXPE3 as a novel biomarker for hypertensive intracerebral hemorrhage risk prediction and targeted therapy [0.03%]
高血压性脑出血外周血免疫特征及新型预测和治疗靶标NXPE3的鉴定
Meng Zhang,Jingyuan Ning,Jing Liu et al.
Meng Zhang et al.
We employed bulk RNA-seq and scRNA-seq techniques to analyze the immune dysregulation in patients with intracerebral hemorrhage (ICH). The study revealed that excessive inflammatory responses, neutrophil activation, and T-cell dysfunction a...