Lactobacillus reuteri-mediated dietary xylooligosaccharides enhance jejunal cell survival via suppression of oxygen-dependent apoptotic processes in a pig model [0.03%]
枯草芽孢杆菌介导的饮食木糖低聚糖通过抑制猪模型空肠细胞氧依赖性凋亡过程来增强空肠细胞存活率
Fuli Deng,Chang Yin,Chengzeng Luo et al.
Fuli Deng et al.
Interactions between functional oligosaccharides and small intestinal cells are increasingly recognized as critical for maintaining intestinal health. Using xylooligosaccharides (XOS) as a model, we demonstrate that XOS promote growth in pi...
The microbiome in cancer [0.03%]
癌症中的微生物组学
Anqi Lin,Minying Xiong,Aimin Jiang et al.
Anqi Lin et al.
The human microbiome is now recognized as a central regulator of cancer biology, intricately shaping tumor development, immune dynamics, and therapeutic response. This comprehensive review delineates the multifaceted roles of bacteria, viru...
PSOSP uncovers pervasive SOS-independent prophages with distinct genomic and host traits in bacterial genomes [0.03%]
PSOSP发现细菌基因组中具有不同基因组和宿主特征的广泛存在的SOS非依赖型前噬菌体
Yali Hao,Mujie Zhang,Xinjuan Lei et al.
Yali Hao et al.
Prophages are ubiquitously present in bacterial genomes, significantly influencing host physiological and ecological functions. We present Prophage SOS-dependency Predictor (PSOSP), a novel bioinformatics tool that predicts prophages induct...
Unveiling soil microbial diversity through ultra-deep short-read metagenomic sequencing and co-assembly [0.03%]
通过超深短读测序和联合组装揭示土壤微生物多样性
Pi Lærke Johansen,Ioanna Chatzigiannidou,Lelde Berzina et al.
Pi Lærke Johansen et al.
By combining ultra-deep short-read shotgun metagenomic sequencing with 5-sample co-assembly across 600 agricultural soil samples, we significantly enhanced the representation and recovery of microbial communities in both clay and sandy soil...
fastp 1.0: An ultra-fast all-round tool for FASTQ data quality control and preprocessing [0.03%]
Fastp 1.0：一款超快的高质量控制及数据预处理工具
Shifu Chen
Shifu Chen
Fastp has been recognized as one of the most popular FASTQ file preprocessors because of its powerful functions and extreme performance. As its first major update, fastp 1.0 will be formally presented in this paper, including its new featur...
RRM2-targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling [0.03%]
靶向RRM2的纳米载体通过铁死亡放大和免疫重塑增强射频消融治疗肝细胞癌的疗效
Weiliang Hou,Weifeng Hong,Songhua Cai et al.
Weiliang Hou et al.
Hepatocellular carcinoma (HCC) is associated with high mortality rates despite the widespread application of radiofrequency ablation (RFA), which has limited therapeutic efficacy as a monotherapy. This study investigated ribonucleotide redu...
scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes [0.03%]
scRiskCell：一种量化2型糖尿病单细胞风险细胞及其适应性动态的框架
Xueqin Xie,Changchun Wu,Fuying Dao et al.
Xueqin Xie et al.
scRiskCell is an interpretable intelligent computational framework that leverages nearly 500,000 islet cell expression profiles from 106 donors across different continuous disease states. By calculating the intrinsic relationship between do...
Functional metagenomics reveals novel antibiotic resistomes in polar soils [0.03%]
功能型元基因组揭示了极地土壤中新型抗生素抗性基因库
Xiuqin Xie,Weibin Cheng,Zhaohong Li et al.
Xiuqin Xie et al.
Using a robust functional metagenomics approach, we demonstrated that polar environments are important reservoirs of novel antibiotic resistance genes (ARGs). DNA was initially extracted from cultured bacterial consortia in the polar soils ...
Multi-omics insights into surface charge effects to decode the interplay of nanoplastics and bacterial antibiotic resistance [0.03%]
多组学视角下表面对电荷效应对纳米塑料和细菌抗生素抗性相互作用的解构研究
Houyu Li,Yinuo Ding,Yan Xu et al.
Houyu Li et al.
Multi-omics approaches revealed how nanoplastics with different surface charges influence antibiotic resistance in Escherichia coli K12. Positively charged nanoplastics enhanced antibiotic resistance by upregulating genes and proteins linke...
RepliChrom: Interpretable machine learning predicts cancer-associated enhancer-promoter interactions using DNA replication timing [0.03%]
基于可解释机器学习的Replichrom模型利用DNA复制时间预测癌症相关的增强子-启动子相互作用
Fuying Dao,Benjamin Lebeau,Crystal Chia Yin Ling et al.
Fuying Dao et al.
RepliChrom is an interpretable machine learning model that predicts enhancer-promoter interactions using DNA replication timing across multiple cell types. By integrating replication timing with chromatin interaction data from multiple expe...