Gut microbial-derived 3,4-dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome [0.03%]
肠道微生物衍生的3,4-二羟基苯乙酸可改善多囊卵巢综合征的生殖表型
Pan Li,Li Xie,Huimin Zheng et al.
Pan Li et al.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and reproductive disorder affecting women of reproductive age. While the gut microbiota has been implicated in PCOS pathophysiology, the role of microbial-derived metabolites as medi...
Distinct microbial and metabolic shifts characterize acute coronary syndrome and recovery [0.03%]
急性冠脉综合征及其康复过程中的微生物和代谢变化特点
Jing Xu,Die Dai,Yanan Yang et al.
Jing Xu et al.
Early identification of patients at risk of acute coronary syndrome (ACS) remains a major unmet need, particularly among those with stable coronary artery disease (sCAD), where timely intervention could markedly improve outcomes. The gut mi...
Xiaofang Yao,Jiqiu Wu,Tengfei Ma et al.
Xiaofang Yao et al.
Social media platforms have revolutionized scientific communication by bridging gaps between researchers, academic journals, and global audiences. This article showcases iMeta, an open-access journal that leverages a diversified social medi...
Editorial
iMeta. 2025 Oct 9;4(5):e70085. DOI:10.1002/imt2.70085 2025
Shaping the future of probiotics, live biotherapeutic products, and fecal microbiota transplantation: 30 scientific recommendations from the CHINAGUT Conference [0.03%]
益生菌、活体生物治疗产品及粪便微生物移植的未来发展方向——CHINA GUT大会提出的30条科学建议
Weihong Wang,Nan Bu,Hailong Cao et al.
Weihong Wang et al.
The 2025 CHINAGUT Conference has assembled a panel of 63 experts (30 scientists, 26 physicians, and 7 corporate R&D personnel) collaborated in three groups to present 30 scientific recommendations to advance probiotics, live biotherapeutic ...
Editorial
iMeta. 2025 Oct 2;4(5):e70083. DOI:10.1002/imt2.70083 2025
Akkermansia muciniphila-derived hypoacylated rough-type lipopolysaccharides alleviate diet-induced obesity via activation of TLR4-IL-23-IL-22 immune axis [0.03%]
通过激活TLR4-IL-23-IL-22免疫轴，Akkermansia muciniphila来源的低乙酰化粗型脂多糖可缓解饮食诱导型肥胖
Li Sun,Yuting Zhang,Wang Dong et al.
Li Sun et al.
Lipopolysaccharides (LPS) derived from intestinal symbionts plays a critical role in modulating and maintaining mucosal immunity. In this study, we investigated the chemical characteristics and antiobesity properties of Akkermansia muciniph...
A gut microbiota-bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N [0.03%]
肠道微生物群-胆汁酸轴通过靶向其细胞受体氨基肽酶N来抑制新兴冠状病毒感染
Ya-Qing Zhang,Bin Wang,Yong-Le Yang et al.
Ya-Qing Zhang et al.
Porcine deltacoronavirus (PDCoV) is a significant pathogen of swine with a global distribution, leading to severe gastrointestinal disease and substantial economic losses. Furthermore, PDCoV poses a potential threat to human health, as evid...
Characterizing the microbiome of "sterile" organs in experimental mice and evidence of translocation of bacteria from the gut to other internal organs [0.03%]
实验性小鼠“无菌”器官的微生物组特征及肠道细菌向其他内脏器官易位的证据
Ming Xu,Shuyun Guan,Chaoran Zhong et al.
Ming Xu et al.
Using culturomics and metagenomics, we demonstrate the existence of non-pathogenic microbiota in the internal organs of healthy experimental mice, challenging the traditional dogma of organ sterility. Based on the analysis of 104 commercial...
Geographic containment and virulence-resistance trade-offs drive the evolution of hypervirulent Klebsiella pneumoniae [0.03%]
地理限制和毒力-耐药权衡驱动高毒性的肺炎克雷伯菌的进化
Yuchen Wu,Fan Pu,Zelin Yan et al.
Yuchen Wu et al.
The emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hvCRKP) represents an alarming convergence of enhanced virulence and extensive drug resistance. Here, we present a comprehensive genomic analysis of 2563 clonal comp...
SynCom-mediated herbicide degradation activates microbial carbon metabolism in soils [0.03%]
基于合成基因线路的除草剂降解激活土壤微生物碳代谢
Yuxiao Zhang,Jack A Gilbert,Xuan Liu et al.
Yuxiao Zhang et al.
Extensive herbicide residues in the black soil of northeastern China are considered a significant agricultural pollution threat, yet effective bioremediation of this complex and persistent mixture remains a challenge. We identified 16 bacte...
Multi-omics identifies microbiota-derived deoxycholic acid as a key mediator of blood-brain barrier dysfunction in Parkinson's disease [0.03%]
多组学鉴定出胆汁酸去氧胆酸是帕金森病血脑屏障功能障碍的关键介导因素
Zhe Zhao,Jing Chen,Yixuan Liu et al.
Zhe Zhao et al.
The gut microbiota derived from Parkinson's disease patients, enriched in Bacteroides fragilis (B. fragilis) and Phocaeicola vulgatus (P. vulgatus), may promote the elevations of deoxycholic acid, iso-deoxycholic acid, and ursodeoxycholic a...