Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A-YTHDF2-dependent mechanism [0.03%]
同环辛啶通过mRNA第六位腺苷酸化(YTHDF2依赖型机制)调控EWSR1相分离从而抑制急性髓系白血病进展
Ting-Ting Liu,Li-Ting Chen,Xu-Ying Pei et al.
Ting-Ting Liu et al.
Homoharringtonine (HHT) is widely used in combination regimens for acute myeloid leukemia (AML), yet its direct cellular targets remain undefined, limiting precision application. Here, we identified EWS RNA-binding protein 1 (EWSR1) as the ...
Soil-borne legacy facilitates the dissemination of antibiotic resistance genes in soil-plant continua [0.03%]
土传遗迹促进了土壤植物体系中抗生素抗性基因的传播
Zufei Xiao,Kai Ding,Xiaodong Guo et al.
Zufei Xiao et al.
Antimicrobial resistance (AMR) disseminates throughout the soil-plant continuum via complex microbial interactions. Plants shape root- and leaf-associated microbiomes that sustain plant health; however, soil-borne legacies-enriched with ant...
Whole microbiota transplantation restores gut homeostasis throughout the gastrointestinal tract [0.03%]
全微生物群移植恢复整个胃肠道的肠道稳态
Bufu Tang,Yuan Cao,Jiasu Li et al.
Bufu Tang et al.
This study introduces whole microbiota transplantation (WMT), a synergistic therapeutic approach that concurrently transplants small intestinal and fecal microbiota. In germ-free mice, WMT outperforms conventional fecal microbiota transplan...
Single-nucleus RNA sequencing reveals RUNX1 regulation of muscle hypertrophy through PI3K/AKT/mTOR pathway [0.03%]
单核RNA测序揭示RUNX1通过PI3K/AKT/mTOR信号通路调控肌肉肥大
Chenxu Wang,Junjie Ma,Yibin Wang et al.
Chenxu Wang et al.
We used snRNA-seq to construct a high-resolution atlas of pectoral muscle development in broiler chickens from neonatal to adult stages. This analysis revealed pronounced molecular heterogeneity among satellite cells across developmental ph...
High-throughput generic single-entity sequencing using droplet microfluidics [0.03%]
基于微流控的高通量单实体测序技术
Guoping Wang,Liuyang Zhao,Yu Shi et al.
Guoping Wang et al.
Single-cell sequencing has revolutionized our understanding of cellular heterogeneity by providing a micro-level perspective in the past decade. While heterogeneity is fundamental to diverse biological communities, existing platforms are pr...
Zhihao Zhu,Lin Zhang,Xiaofang Yao et al.
Zhihao Zhu et al.
The iMeta Conference 2025, part of the iMeta Conference series, themed "Creating High-Impact International Journals," held at the Huangjiahu Campus of Hubei University of Chinese Medicine from August 23rd to 25th, 2025, and focused on front...
Editorial
iMeta. 2025 Oct 15;4(6):e70086. DOI:10.1002/imt2.70086 2025
Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs [0.03%]
多组学分析揭示猪复杂性状选择印记和位点
Lei Liu,Guoqiang Yi,Yilong Yao et al.
Lei Liu et al.
The genetic basis of complex traits and phenotypic differentiation remains unclear in pigs. Using nine genomes-seven of which were newly generated, high-quality de novo assembled genomes-and 1081 resequencing genomes, we built a pan-genome ...
Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch Signaling [0.03%]
二甲双胍通过激活诺特定理信号通路保护肩袖损伤
Can Liu,Runqi Wang,Yong Xu et al.
Can Liu et al.
Type 2 Diabetes Mellitus (T2DM) is a growing global health concern that is associated with severe complications including diabetic tendinopathy. In this study, we found that T2DM patients had a significantly higher prevalence of tendon surg...
Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP-IV and microbiota [0.03%]
一种新型四肽葡萄糖稳态调节剂的发现：兼具DPP-IV靶向和调节肠道菌群双功能性质
Haihong Chen,Wei Li,Wei Hu et al.
Haihong Chen et al.
AI-driven and computation-based high-throughput methods were developed to mine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hemp seed proteins. The identified peptide VAMP demonstrates a glucose-lowering effect through du...
Bavachalcone targets transferrin receptor and sensitizes gemcitabine to affect bladder cancer progression [0.03%]
Bavachalcone靶向转铁蛋白受体以增强吉西他滨对膀胱癌的治疗作用
Zihao Zhang,Chenyue Yuan,Qintao Ge et al.
Zihao Zhang et al.
Gemcitabine resistance drives bladder cancer recurrence and progression. Using high-throughput drug screening in bladder cancer cells, we identified Bavachalcone (Bava) as a potent gemcitabine sensitizer. Mechanistically, Bava simultaneousl...