Pangenome and genome variation analyses of pigs unveil genomic facets for their adaptation and agronomic characteristics [0.03%]
猪泛基因组和基因组变异分析揭示了适应性和农艺性状的基因组特征
Dong Li,Yulong Wang,Tiantian Yuan et al.
Dong Li et al.
The development of a comprehensive pig graph pangenome assembly encompassing 27 genomes represents the most extensive collection of pig genomic data to date. Analysis of this pangenome reveals the critical role of structural variations in d...
MetOrigin 2.0: Advancing the discovery of microbial metabolites and their origins [0.03%]
MetOrigin 2.0：推进微生物代谢物及其来源的发现
Gang Yu,Cuifang Xu,Xiaoyan Wang et al.
Gang Yu et al.
First introduced in 2021, MetOrigin has quickly established itself as a powerful web server to distinguish microbial metabolites and identify the bacteria responsible for specific metabolic processes. Building on the growing understanding o...
Bioprospecting of culturable marine biofilm bacteria for novel antimicrobial peptides [0.03%]
可培养海洋微生物 mats 筛选新型抗菌肽的研究
Shen Fan,Peng Qin,Jie Lu et al.
Shen Fan et al.
Antimicrobial peptides (AMPs) have become a viable source of novel antibiotics that are effective against human pathogenic bacteria. In this study, we construct a bank of culturable marine biofilm bacteria constituting 713 strains and their...
Short-term probiotic supplementation affects the diversity, genetics, growth, and interactions of the native gut microbiome [0.03%]
短期益生元补充影响肠道微生物组的多样性、遗传性、生长和相互作用
Xin Shen,Hao Jin,Feiyan Zhao et al.
Xin Shen et al.
The precise mechanisms through which probiotics interact with and reshape the native gut microbiota, especially at the species and genetic levels, remain underexplored. This study employed a high-dose probiotic regimen of Bifidobacterium an...
Moyang Liu,Ming Yang,Heng Liang et al.
Moyang Liu et al.
Polyploidization promotes the functional diversification of autophagy in plants, expanding autophagy-associated genes (AAGs) to support processes like chloroplast division and flowering. Analysis of 92,967 AAGs in Arabidopsis thaliana, Sola...
Comprehensive multi-tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding [0.03%]
综合的多组织羊表观基因组图谱：复杂性状、驯化和育种的资源
Deyin Zhang,Jiangbo Cheng,Xiaolong Li et al.
Deyin Zhang et al.
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic functional annotation of the sheep genome is lacking. Here, we generated 92 transcriptomic and epig...
Gut Bifidobacterium pseudocatenulatum protects against fat deposition by enhancing secondary bile acid biosynthesis [0.03%]
肠道乳杆菌假链状噬菌体通过增强二次胆酸生物合成来预防脂肪沉积
Andong Zha,Ming Qi,Yuankun Deng et al.
Andong Zha et al.
Gut microbiome is crucial for lipid metabolism in humans and animals. However, how specific gut microbiota and their associated metabolites impact fat deposition remains unclear. In this study, we demonstrated that the colonic microbiome of...
iNAP 2.0: Harnessing metabolic complementarity in microbial network analysis [0.03%]
基于微生物网络分析的代谢互补性研究 iNAP 2.0
Xi Peng,Kai Feng,Xingsheng Yang et al.
Xi Peng et al.
With the widespread adoption of metagenomic sequencing, new perspectives have emerged for studying microbial ecological networks, yielding metabolic evidence of interspecies interactions that traditional co-occurrence networks cannot infer....
TCellSI: A novel method for T cell state assessment and its applications in immune environment prediction [0.03%]
TCellSI：一种新的T细胞状态评估方法及其在免疫环境预测中的应用
Jing-Min Yang,Nan Zhang,Tao Luo et al.
Jing-Min Yang et al.
T cell is an indispensable component of the immune system and its multifaceted functions are shaped by the distinct T cell types and their various states. Although multiple computational models exist for predicting the abundance of diverse ...
Interaction between intestinal mycobiota and microbiota shapes lung inflammation [0.03%]
肠道真菌和细菌的相互作用影响肺部炎症反应
Youxia Wang,Fang He,Bingnan Liu et al.
Youxia Wang et al.
Gut microbiota is an intricate microbial community containing bacteria, fungi, viruses, archaea, and protozoa, and each of them contributes to diverse aspects of host health. Nevertheless, the influence of interaction among gut microbiota o...