Gut microbiome and metabolome characteristics of patients with cholesterol gallstones suggest the preventive potential of prebiotics [0.03%]
胆固醇胆石症患者的肠道菌群和代谢特点提示益生元的预防潜力
Ye Liu,Hexin Li,Tianhan Sun et al.
Ye Liu et al.
Cholesterol gallstones (CGS) still lack effective noninvasive treatment. The etiology of experimentally proven cholesterol stones remains underexplored. This cross-sectional study aims to comprehensively evaluate potential biomarkers in pat...
Non-differential gut microbes contribute to hypertension and its severity through co-abundances: A multi-regional prospective cohort study [0.03%]
肠道中的非差异性微生物通过共丰度影响高血压及其严重程度：一项多地区前瞻性队列研究
Lu Liu,Qianyi Zhou,Tianbao Xu et al.
Lu Liu et al.
Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non-dif...
Hypertriglyceridemia-modulated gut microbiota promotes lysophosphatidylcholine generation to aggravate acute pancreatitis in a TLR4-dependent manner [0.03%]
高甘油三酯血症调节的肠道微生物群通过促进溶磷脂胆碱的生成以TLR4依赖性方式加重急性胰腺炎
Xiaofan Song,Lei Qiao,Xina Dou et al.
Xiaofan Song et al.
Hypertriglyceridemia (HTG) can lead to the disorder of gut microbiota in mice, resulting in the increase of endotoxin content. HTG can also aggravate the damage of intestinal barrier function and intestinal bacterial translocation in acute ...
Scalable method for exploring phylogenetic placement uncertainty with custom visualizations using treeio and ggtree [0.03%]
利用treeio和ggtree进行自定义可视化探索系统发育定位不确定性的可扩展方法
Meijun Chen,Xiao Luo,Shuangbin Xu et al.
Meijun Chen et al.
In metabarcoding research, such as taxon identification, phylogenetic placement plays a critical role. However, many existing phylogenetic placement methods lack comprehensive features for downstream analysis and visualization. Visualizatio...
Cross-tissue multi-omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism [0.03%]
跨组织多组学分析揭示肠道微生物的缺失影响器官形态、免疫稳态以及胆汁酸和脂质代谢
Juan Shen,Weiming Liang,Ruizhen Zhao et al.
Juan Shen et al.
The gut microbiota influences host immunity and metabolism, and changes in its composition and function have been implicated in several non-communicable diseases. Here, comparing germ-free (GF) and specific pathogen-free (SPF) mice using sp...
Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance [0.03%]
通过累积的菌群紊乱分析将膳食纤维与人类疾病相联系
Xin Zhang,Huan Liu,Yu Li et al.
Xin Zhang et al.
Dietary fiber influences the composition and metabolic activity of microbial communities, impacting disease development. Current understanding of the intricate fiber-microbe-disease tripartite relationship remains fragmented and elusive, ur...
Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities [0.03%]
肠道微生物在治疗炎症性消化疾病中的作用：当前挑战与治疗机会
Yongpeng Shi,Zeran Chen,Tingyu Fang et al.
Yongpeng Shi et al.
Accumulating evidence indicates that the gut microbiota is intricately involved in the initiation and progression of human diseases, forming a multidirectional regulatory axis centered on intestinal microbiota. This article illustrates the ...
MicrobiomeStatPlots: Microbiome statistics plotting gallery for meta-omics and bioinformatics [0.03%]
微生物组统计图库：用于元组学和生物信息学的微生物群统计绘图.gallery
Defeng Bai,Chuang Ma,Jiani Xun et al.
Defeng Bai et al.
The rapid growth of microbiome research has generated an unprecedented amount of multi-omics data, presenting challenges in data analysis and visualization. To address these issues, we present MicrobiomeStatPlots, a comprehensive platform o...
Gut-X axis [0.03%]
肠-脑轴
Xu Lin,Zuxiang Yu,Yang Liu et al.
Xu Lin et al.
Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, inc...