Bacterial abundance and diversity in 64-74 Ma subseafloor igneous basement from the Louisville Seamount Chain [0.03%]
采自路易斯福火山链的64-74百万年前igneous Basement中底栖细菌的数量和多样性
Jason B Sylvan,Benjamin J Tully,Yuki Morono et al.
Jason B Sylvan et al.
The aquifer in the subseafloor igneous basement is a massive, continuous microbial substrate, yet sparingly little is known about life in this habitat. The work to date has focused largely on describing microbial diversity in the young base...
Optimizing enzyme thermostability by combining multiple mutations using protein language model [0.03%]
利用蛋白质语言模型结合多个突变以优化酶的热稳定性
Jiahao Bian,Pan Tan,Ting Nie et al.
Jiahao Bian et al.
Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi-)rational design and random mutagenesis methods can accurately identify single-point mutations that enhance enz...
Sodium dodecyl sulfate-coated silver nanoparticles accelerate antimicrobial potentials by targeting amphiphilic membranes [0.03%]
十二烷基硫酸钠包覆的银纳米颗粒通过靶向两亲性膜加速抗菌性能
Xiuyan Jin,Na Peng,Aoran Cui et al.
Xiuyan Jin et al.
Compelling concerns about antimicrobial resistance and the emergence of multidrug-resistant pathogens call for novel strategies to address these challenges. Nanoparticles show promising antimicrobial activities; however, their actions are h...
GRAPE-WEB: An automated computational redesign web server for improving protein thermostability [0.03%]
GRAPE-WEB：一种用于改善蛋白质热稳定性的自动化计算设计网络服务器
Jinyuan Sun,Wenyu Shi,Zhihui Xing et al.
Jinyuan Sun et al.
We have developed the GReedy Accumulated strategy for Protein Engineering (GRAPE) to improve enzyme stability across various applications, combining advanced computational methods with a unique clustering and greedy accumulation approach to...
Photosynthesis by nonphotosynthetic microorganisms via semiconductor photocatalysis [0.03%]
非光合微生物的半导体光催化合成作用
Bo Wang,Liang Shi,Anhuai Lu
Bo Wang
Wenchen Song
Wenchen Song
Staphylococcus aureus SOS response: Activation, impact, and drug targets [0.03%]
金黄色葡萄球菌SOS反应：激活、影响和药物靶点
Kaiying Cheng,Yukang Sun,Huan Yu et al.
Kaiying Cheng et al.
Staphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic-resistan...
Siqi Tian,Tao Ding,Hui Li
Siqi Tian
The oral cavity contains the second-largest microbiota in the human body. The cavity's anatomically and physiologically diverse niches facilitate a wide range of symbiotic bacteria living at distinct oral sites. Consequently, the oral micro...
Yingxi Li,Sirui Han,Haichun Gao
Yingxi Li
Heme is an important cofactor and a regulatory molecule involved in various physiological processes in virtually all living cellular organisms, and it can also serve as the primary iron source for many bacteria, particularly pathogens. Howe...
Zinc finger 4 negatively controls the transcriptional activator Fzf1 in Saccharomyces cerevisiae [0.03%]
锌指转录因子ZnF4通过结合负调控酿酒酵母中端芽启动子中的TEA motif转录激活因子FZF1
Ying Du,Chaoqun Ma,Stanley A Moore et al.
Ying Du et al.
Fzf1 is a Saccharomyces cerevisiae transcription factor containing five zinc fingers (ZFs). It regulates the expression of at least five downstream genes, including SSU1, YHB1, DDI2/3, and YNR064c, by recognizing a consensus sequence, CS2, ...