Novel plasmid pCM3 harboring the aph(3) gene confers phosphorylation-driven streptomycin resistance in Clavibacter michiganensis [0.03%]
新型质粒pCM3携带aph(3)基因使 клавибakter michiganensis 具有磷酸化驱动的链霉素抗性
Xiaoli Xu,Cen Qian,Zhigang Hao et al.
Xiaoli Xu et al.
Antibiotic resistance in plant pathogens threatens sustainable crop protection, and yet, its molecular basis remains incompletely understood. We report that streptomycin resistance in Clavibacter michiganensis strain TX-0702 is mediated by ...
SARS-CoV-2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release [0.03%]
SARS-CoV-2增强溶酶体胞外分泌并使溶酶体脱酸以促进病毒释放
Fujun Qin,Chuang Yan,Zizheng Liu et al.
Fujun Qin et al.
The mechanism of SARS-CoV-2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In th...
Microbially driven organic carbon cycling at the land-sea interface: Advances and an integrated study framework [0.03%]
介导陆海交界带有机碳循环的微生物：进展与整合研究框架
Quanrui Chen,Kai Tang,Zhili He et al.
Quanrui Chen et al.
The land-sea interface is a vital component of global biogeochemical cycles, where microorganisms drive the cycling of carbon, nitrogen, and sulfur. This review synthesizes the research progress from representative land-sea interfaces to el...
The toxin-antitoxin complex Fic-1-AntF functions as a deAMPylase that regulates the activity of DNA gyrase [0.03%]
毒素-抗毒素复合体Fic-1-AntF具有脱腺苷酸化酶功能并可调节DNA回旋酶活性
Furong Chen,Liwei Guo,Canhua Lu et al.
Furong Chen et al.
Toxin-antitoxin (TA) systems found in diverse bacteria play important roles in their adaptation to changing environments. The toxin of the Fic-1-AntF TA pair from Pseudomonas bijieensis strain 2P24 inhibits bacterial DNA replication by atta...
Protists show high resilience and thrive under multiple chemical stressors [0.03%]
原生生物表现出很高的恢复力并在多种化学胁迫下茁壮成长
Jijuan Ding,Fei Liu,Yuanchen Zhao et al.
Jijuan Ding et al.
Protists are an underexplored but functionally important component of aerobic-activated granular sludge under pollution stress. Using metagenomics, we profiled protistan responses to ciprofloxacin, triclosan, and Cu2+ (alone or in combinati...
Hui Li,Xuanyu Tao,Lina Sun et al.
Hui Li et al.
The growing global plastic waste crisis demands the development of urgent, effective, and sustainable solutions. While conventional recycling methods present intrinsic limitations, microbial biodegradation of plastic waste has emerged as a ...
Challenging the prokaryotic MGE-defense origin of eukaryotic RNA editing [0.03%]
挑战原核生物MGE-防御起源的真核生物RNA编辑机制
Yuange Duan,Qiuhua Xie,Jiajia Yang et al.
Yuange Duan et al.
Xiao Han,Xiaofu Wan,Yang Zhou et al.
Xiao Han et al.
Antimicrobial resistance poses an escalating global threat, renewing interest in bacteriophage therapy as a precision alternative to antibiotics. However, clinical translation remains hindered by the lack of rapid and quantitative phage sus...
Cefdinir reprograms Gram-positive bacteria to synergize with lysozyme against superbugs [0.03%]
cefdirin重塑革兰氏阳性菌使之与溶菌酶协同作用对抗超级细菌
Qi Zhang,Yang Yang,Shuqi Li et al.
Qi Zhang et al.
Multidrug-resistant (MDR) bacteria pose a critical global health threat, urgently requiring solutions. Cefdinir, the highest-selling third-generation cephalosporin but one now facing clinical obsolescence due to escalating resistance, is co...
The oxygen-sensing FixLJ represses nitrogen fixation in Rhodopseudomonas palustris in response to oxygen [0.03%]
光合细菌红假单胞菌的氧感受蛋白FixLJ通过响应氧气抑制生物固氮反应
Lingwei Cui,Yan Zeng,Mengmei Wang et al.
Lingwei Cui et al.
Biological nitrogen fixation in symbiotic diazotrophs is subject to oxygen regulation by an oxygen-sensing FixLJ two-component system under micro-oxic conditions. However, it remains unclear whether this mechanism is conserved in free-livin...