Evidence for fomite transmission of SARS-CoV-2 Omicron variant in a mouse model [0.03%]
小鼠模型中SARS-CoV-2奥密克戎变异株经污染物传播的证据
Sidi Yang,Liu Cao,Kun Li et al.
Sidi Yang et al.
Throughout the COVID-19 pandemic, the risk of fomite-based transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been systematically investigated. In this study, we employed the K18-hACE2 mouse infection model...
Legionella pneumophila modulates the host cytoskeleton by an effector of transglutaminase activity [0.03%]
Legionella pneumophila利用转谷氨酰胺酶活性效应子调节宿主细胞骨架
Yan Liu,Yao Liu,Zhao-Qing Luo
Yan Liu
The bacterial pathogen Legionella pneumophila delivers more than 330 effector proteins into host cells through its Dot/Icm type IV secretion system (T4SS) to facilitate its intracellular replication. A number of these effectors modulate org...
Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria [0.03%]
利用宿主敏感性来抑制细菌中噬菌体抗性的进化
Yongqi Mu,Yuqin Song,Xueru Tian et al.
Yongqi Mu et al.
The escalating antibiotic resistance crisis poses a major global health threat. Bacteriophage therapy offers a promising alternative for combating multidrug-resistant infections. However, bacterial resistance to phages remains a significant...
Engineering archaeal membrane-spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations [0.03%]
工程再造细菌合成膜脂GDGT：对早期生命膜转化的启示
Huahui Chen,Fengfeng Zheng,Xi Feng et al.
Huahui Chen et al.
Eukaryotes are hypothesized to be archaeal-bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial-type memb...
Coevolutionary training of phages can be more successful in several small, relative to single large, habitats [0.03%]
噬菌体的协同进化训练可以在几个较小的栖息地而非一个较大的栖息地中更成功地进行
Xiao Liu,Quan-Guo Zhang
Xiao Liu
Evolutionary training of phages can help to counter bacterial resistance evolution. Here, we address whether metapopulation processes can enhance the evolution of phage infectivity. Our experiment with a model bacterium-phage system support...
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria [0.03%]
苯基酯类抗结核药克拉维达菌素的同系物克利莫霉素的作用机制研究及其对分枝杆菌ClpP1P2蛋白酶的选择性抑制作用分析
Genhui Xiao,Yumeng Cui,Liangliang Zhou et al.
Genhui Xiao et al.
The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substa...
Discovery, design, and engineering of enzymes based on molecular retrobiosynthesis [0.03%]
基于分子逆合成的酶的发现、设计与工程化
Ancheng Chen,Xiangda Peng,Tao Shen et al.
Ancheng Chen et al.
Biosynthesis-a process utilizing biological systems to synthesize chemical compounds-has emerged as a revolutionary solution to 21st-century challenges due to its environmental sustainability, scalability, and high stereoselectivity and reg...
The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates n-alkane degradation in Pseudomonas aeruginosa SJTD-1 [0.03%]
铜绿假单胞菌SJTD-1中GntR/VanR型转录调节因子AlkR调控烷烃降解基因表达及n-烷烃降解性能的作用机制研究
Wanli Peng,Xiuli Wang,Qinchen Liu et al.
Wanli Peng et al.
Transmembrane alkane monooxygenase (AlkB)-type monooxygenases, especially AlkB2 monooxygenases, are crucial for aerobic degradation of the medium-to-long-chain n-alkanes in hydrocarbon-utilizing microorganisms. In this study, we identified ...
An archaeal virus capable of hydrolyzing the surface glycan of the host cell [0.03%]
一种能够水解宿主细胞表面多糖的古菌病毒
Wanjuan Yuan,Caixia Pei,Junkai Huang et al.
Wanjuan Yuan et al.
Spindle-shaped viruses exclusively infect archaea. Fuselloviruses represent a large group of spindle-shaped viruses and infect hyperthermophilic archaea of the order Sulfolobales. Although the first fusellovirus was identified nearly 40 yea...
[This corrects the article DOI: 10.1002/mlf2.12049.]. © 2025 The Author(s). mLife published by John Wiley & Sons Australia, Ltd on behalf of Institute o...
Published Erratum
mLife. 2025 Mar 27;4(2):226. DOI:10.1002/mlf2.12166 2025