GTP cycling protein (GCP): An ancient player for allosteric gatekeeping [0.03%]
GTP循环蛋白(GCP)：一种古老的别构门控调控因子
Ji-Long Liu
Ji-Long Liu
A butyrate-producing synbiotic mitigates intestinal inflammation in a murine colitis model [0.03%]
丁酸产生型合生元可通过调节肠道菌群减轻小鼠结肠炎模型中的肠道炎症
Hyuna Sung,Soo Yoon Cho,Seong Hyeok Ma et al.
Hyuna Sung et al.
Inflammatory bowel disease (IBD) is a chronic condition characterized by intestinal inflammation and gut dysbiosis, with limited treatment options primarily focused on immune-modulating therapies. Among potential therapeutic agents, butyrat...
The global genomic landscape of hypervirulent Klebsiella pneumoniae from 1932 to 2021 [0.03%]
1932至2021年全球高毒力肺炎克雷伯菌的基因组景观
Xiaoyuan Jiang,Shuangshuang Li,Cuidan Li et al.
Xiaoyuan Jiang et al.
The global spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious public health threat. In this study, we conducted genomic epidemiology analysis on 2097 global hvKp isolates, including our 900 isolates sequenced through the I...
Regulation of filamentous phage Pf4 activation by oxidative stress in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌中的氧化应激调控丝状噬菌体Pf4的激活
Zixian Huang,Xinqiao Zhang,Shituan Lin et al.
Zixian Huang et al.
The filamentous prophage Pf4 is activated to produce phage virions during Pseudomonas aeruginosa biofilm formation, a process crucial for maintaining biofilm architecture and enhancing pathogenicity. However, the environmental cues triggeri...
The antibacterial effect of tellurite is achieved through intracellular acidification and magnesium disruption [0.03%]
碲化物的抗菌效果是通过细胞内酸化和镁离子干扰实现的
Wanli Peng,Yali Fu,Yanqiu Wang et al.
Wanli Peng et al.
Antibiotic resistance has caused a severe reduction in bacteriostatic action and clinical therapy, demanding effective agents or strategies. Tellurite is an ancient yet powerful antimicrobial agent with an ambiguous mechanism. In this study...
Neutralizing antibodies in the intestinal mucosa are essential to control gastrointestinal infection by Shiga toxin-producing Escherichia coli [0.03%]
肠道黏膜中的中和抗体对控制致病性大肠杆菌感染至关重要
Alan Mauro Bernal,Fernando Nicolás Sosa,Yina María Carpintero-Polanco et al.
Alan Mauro Bernal et al.
Infections with Shiga toxin (Stx)-producing Escherichia coli (STEC) strains can result in a wide range of clinical presentations. Despite STEC O157:H7 being the serotype most frequently associated with hemolytic uremic syndrome (HUS), in so...
Not too rigid nor too wobbly: Defining an optimal membrane fluidity range essential for biofilm formation in Escherichia coli [0.03%]
非僵硬亦不摇摆：界定形成生物被膜的最优膜流动性范围（以大肠杆菌为例）
Yaoqin Hong,Jilong Qin,Makrina Totsika
Yaoqin Hong
Membrane fluidity plays a crucial role in bacterial fitness and adaptation to cope with rapid environmental changes. While high membrane fluidity promotes robust biofilm formation in Klebsiella pneumoniae, studies in several other species, ...
Conserved mycobacterial sRNA B11 regulates lipooligosaccharide synthesis at posttranscriptional level in Mycobacterium marinum [0.03%]
保守的结核分枝杆菌小分子RNA B11通过转录后调控调节海洋分枝杆菌脂寡糖合成
Chuan Wang,Cheng Bei,Yufeng Fan et al.
Chuan Wang et al.
Extractable glycolipids of mycobacteria, such as lipooligosaccharides (LOSs), play crucial roles in responding to environmental stress and modulating the host immune response. Although the biosynthesis of LOS is likely regulated at multiple...
Mechanistic insights into the T6SS of multi-drug-resistant Aeromonas hydrophila and its role in competition and pathogenesis [0.03%]
肠杆菌科细菌耐药性菌株的T6SS作用机制及其在竞争和致病中的作用
Hao Wang,Ying Liu,Zhao Wang et al.
Hao Wang et al.
Aeromonas hydrophila, an opportunistic pathogen, often encodes Type VI Secretion System (T6SS) genes. However, the specific functions of T6SS, particularly in the context of clinical strains, remain poorly understood. In this study, we char...
Extensive lateral gene transfer between proto-eukaryotes and Heimdallarchaeia suggests their close association during eukaryogenesis [0.03%]
拟真核生物与Heimdallarchaea之间广泛的水平基因转移表明它们在真核细胞发生过程中的密切关联
Patrick Forterre
Patrick Forterre
It has been proposed by Ettema and colleagues, in the two-domain framework for the tree of life, that Eukarya emerged from Heimdallarchaeia, as sister group to Hodarchaeales. Looking at the individual trees of the protein markers used by th...