Microbiome-driven anticancer therapy: A step forward from natural products [0.03%]
微生物驱动的抗癌疗法——超越天然产物的一步飞跃
Yunxuan Guan,Di Wu,Hui Wang et al.
Yunxuan Guan et al.
Human microbiomes, considered as a new emerging and enabling cancer hallmark, are increasingly recognized as critical effectors in cancer development and progression. Manipulation of microbiome revitalizing anticancer therapy from natural p...
Zheng Qu,Xianfeng Ren,Zhaolin Du et al.
Zheng Qu et al.
Mycotoxins, which are secondary metabolites produced by toxicogenic fungi, are natural food toxins that cause acute and chronic adverse reactions in humans and animals. The genus Fusarium is one of three major genera of mycotoxin-producing ...
Dual activities of a silencing information regulator complex in yeast transcriptional regulation and DNA-damage response [0.03%]
酵母转录调控和DNA损伤反应中的沉默信息调节器复合体的双重功能
Josephine Rybchuk,Wei Xiao
Josephine Rybchuk
The Saccharomyces cerevisiae silencing information regulator (SIR) complex contains up to four proteins, namely Sir1, Sir2, Sir3, and Sir4. While Sir2 encodes a NAD-dependent histone deacetylase, other SIR proteins mainly function as struct...
A novel alcohol dehydrogenase in the hyperthermophilic crenarchaeon Hyperthermus butylicus [0.03%]
嗜热厚壁球菌中的新型酒精脱氢酶
Ching Tse,Kesen Ma
Ching Tse
Hyperthermus butylicus is a hyperthermophilic crenarchaeon that produces 1-butanol as an end product. A thermostable alcohol dehydrogenase (ADH) must be present in H. butylicus to act as the key enzyme responsible for this production; howev...
Phage-displayed heptapeptide sequence conjugation significantly improves the specific targeting ability of antimicrobial peptides against Staphylococcus aureus [0.03%]
七肽噬菌体展示序列的连接显著提高了抗菌肽对金黄色葡萄球菌的作用特异性
Tao Wang,Peng Tan,Qi Tang et al.
Tao Wang et al.
Broad-spectrum antibacterial drugs often lack specificity, leading to indiscriminate bactericidal activity, which can disrupt the normal microbial balance of the host flora and cause unnecessary cytotoxicity during systemic administration. ...
Elucidating microbial iron corrosion mechanisms with a hydrogenase-deficient strain of Desulfovibrio vulgaris [0.03%]
用氢化酶缺陷型脱硫弧菌品系阐明微生物铁腐蚀机制
Di Wang,Toshiyuki Ueki,Peiyu Ma et al.
Di Wang et al.
Sulfate-reducing microorganisms extensively contribute to the corrosion of ferrous metal infrastructure. There is substantial debate over their corrosion mechanisms. We investigated Fe0 corrosion with Desulfovibrio vulgaris, the sulfate red...
Identification of 3-ketocapnine reductase activity within the human microbiota [0.03%]
人类微生物群中3-酮帽碱还原酶活性的鉴定
Xiaotong Wu,Lukuan Hou,Haili Zhang et al.
Xiaotong Wu et al.
The microbial synthesis of sulfonolipids within the human body is likely involved in maintaining human health or causing diseases. However, the enzymes responsible for their biosynthesis remain largely unknown. In this study, we identified ...
Cinnamaldehyde targets SarA to enhance β-lactam antibiotic activity against methicillin-resistant Staphylococcus aureus [0.03%]
肉桂醛作用于SarA以增强β-内酰胺类抗生素对耐甲氧西林金黄色葡萄球菌的效果
Jianguo Li,Tingyin Lu,Yuefei Chu et al.
Jianguo Li et al.
Methicillin-resistant Staphylococcus aureus (MRSA) is a current global public health problem due to its increasing resistance to the most recent antibiotic therapies. One critical approach is to develop ways to revitalize existing antibioti...
Cofitness network connectivity determines a fuzzy essential zone in open bacterial pangenome [0.03%]
拟水平基因转移的模糊核心菌种及其在开放细菌泛基因组中的连通性分布规律
Pan Zhang,Biliang Zhang,Yuan-Yuan Ji et al.
Pan Zhang et al.
Most in silico evolutionary studies commonly assumed that core genes are essential for cellular function, while accessory genes are dispensable, particularly in nutrient-rich environments. However, this assumption is seldom tested genetical...
Harnessing marine microbiomes to develop a sustainable, all-Atlantic bioeconomy [0.03%]
利用海洋微生物群开发可持续的大西洋生物经济
Cristiane Thompson,Alice C Ortmann,Henk Bolhuis et al.
Cristiane Thompson et al.