EmbB and EmbC regulate the sensitivity of Mycobacterium abscessus to echinomycin [0.03%]
EmbB和EmbC调节嗜胺分枝杆菌对棘霉素的敏感性
Jing He,Yamin Gao,Jingyun Wang et al.
Jing He et al.
Treatment of Mycobacterium abscessus (Mab) infections is very challenging due to its intrinsic resistance to most available drugs. Therefore, it is crucial to discover novel anti-Mab drugs. In this study, we explored an intrinsic resistance...
Metabolic activities of marine ammonia-oxidizing archaea orchestrated by quorum sensing [0.03%]
群体感应调控氨氧化古菌的代谢活动
Olivier Pereira,Wei Qin,Pierre E Galand et al.
Olivier Pereira et al.
Ammonia-oxidizing archaea (AOA) play crucial roles in marine carbon and nitrogen cycles by fixing inorganic carbon and performing the initial step of nitrification. Evaluation of carbon and nitrogen metabolism popularly relies on functional...
Discovery of β-nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition and antivirulence factor therapeutics against Serratia marcescens [0.03%]
塞氏肠杆菌群体感应抑制剂β-亚硝基苯乙烯衍生物的发现及其作为抗细菌毒力药物的作用机制研究
Jiang Wang,Jingyi Yang,Pradeepraj Durairaj et al.
Jiang Wang et al.
Quorum sensing (QS) inhibition has emerged as a promising target for directed drug design, providing an appealing strategy for developing antimicrobials, particularly against infections caused by drug-resistant pathogens. In this study, we ...
Efficient, compact, and versatile: Type I-F2 CRISPR-Cas system [0.03%]
高效、精简和多功能的型II-F2 CRISPR-Cas系统
Shengsheng Ma,Senfeng Zhang,Kunming Liu et al.
Shengsheng Ma et al.
Catalytically active prokaryotic Argonautes employ phospholipase D family proteins to strengthen immunity against different genetic invaders [0.03%]
催化活性的原核Argonautes通过利用磷脂酶D家族蛋白增强对不同遗传入侵者的免疫作用
Feiyue Cheng,Aici Wu,Zhihua Li et al.
Feiyue Cheng et al.
Prokaryotic Argonautes (pAgos) provide bacteria and archaea with immunity against plasmids and viruses. Catalytically active pAgos utilize short oligonucleotides as guides to directly cleave foreign nucleic acids, while inactive pAgos lacki...
The phytopathogen Xanthomonas campestris senses and effluxes salicylic acid via a sensor HepR and an RND family efflux pump to promote virulence in host plants [0.03%]
植物病原菌青枯雷尔利亚菌通过传感器HepR和外排泵家族成员将水杨酸感应并排出，促进其在寄主植物体内致病性
Kai Song,Ruifang Li,Ying Cui et al.
Kai Song et al.
Salicylic acid (SA) plays an essential role in plant defense against biotrophic and semi-biotrophic pathogens. Following pathogen recognition, SA biosynthesis dramatically increases at the infection site of the host plant. The manner in whi...
Perchlorate-tolerant bacterial strains isolated from the Mars-analog Qaidam Basin soils exposed to Earth's near space [0.03%]
采自地球近空间的火星类土壤青海湖盐滩中耐高氯酸盐细菌分离菌株研究
Li Liu,Mengling Kang,Zhe Wang et al.
Li Liu et al.
Earth's lower near space of 20-40 km above sea level with polyextreme conditions serves as a unique Mars analog for astrobiological research to investigate the limits of life on Earth and planetary protection considerations for Mars explora...
Yuqin Mao,Chao Kong,Tongtong Zang et al.
Yuqin Mao et al.
Atherosclerosis is a chronic inflammatory metabolic disease with a complex pathogenesis. However, the exact details of its pathogenesis are still unclear, which limits effective clinical treatment of atherosclerosis. Recently, multiple stud...
Guanhua Xuan,Luying Xun,Yongzhen Xia
Guanhua Xuan
Members of the multiple antibiotic resistance regulator (MarR) protein family are ubiquitous in bacteria and play critical roles in regulating cellular metabolism and antibiotic resistance. MarR family proteins function as repressors, and t...
Filamentation and inhibition of prokaryotic CTP synthase with ligands [0.03%]
ligands对原核CTP合成酶的纤维化和抑制作用研究
Chenjun Guo,Zixuan Wang,Ji-Long Liu
Chenjun Guo
Cytidine triphosphate synthase (CTPS) plays a pivotal role in the de novo synthesis of cytidine triphosphate (CTP), a fundamental building block for RNA and DNA that is essential for life. CTPS is capable of directly binding to all four nuc...