Pressure-dependent adaptation strategies implied by the dissimilatory iron reducer Orenia metallireducens Z6 [0.03%]
铁还原菌Orenia metallireducens Z6的适应策略取决于压力大小
Shuyi Li,Jiahao Pei,Jiasong Fang et al.
Shuyi Li et al.
Tolerance of high hydrostatic pressure (HHP) is the hallmark of deep subsurface microorganisms, while its mechanisms remain under-investigated. This study explores HHP adaptation in the piezotolerant bacterium Orenia metallireducens across ...
Jun Xiao,Yan Yan,Jing Li et al.
Jun Xiao et al.
Bacteria deploy diverse innate immune systems to combat bacteriophage infections. The cyclic-oligonucleotide-based anti-phage signaling system (CBASS) is a type of innate prokaryotic immune system. CBASS synthesizes cyclic-oligonucleotide t...
Antibiotic resistance mediated by site-specific mutations in the multidrug efflux transporter CmeB of zoonotic pathogen Campylobacter [0.03%]
由食源性病原体Campylobacter的多药外排转运蛋白CmeB特定位点突变介导的抗性机制研究
Xiaolong Lin,Mengyu Zhao,Jianhong Gan et al.
Xiaolong Lin et al.
The resistance‒nodulation‒division (RND) family of multidrug efflux transporters is widely distributed in Gram-negative bacteria. Although their roles in mediating antibiotic resistance have been well known, our understanding of how they ...
Berberrubine inhibits Helicobacter pylori by inducing oxidative stress and impairing membrane integrity [0.03%]
伯柏鲁比因为诱导氧化应激和破坏细胞膜完整性而抑制幽门螺旋杆菌
Minzhi Jiang,Changyu Wang,Kai Wang et al.
Minzhi Jiang et al.
Helicobacter pylori is a major gastric pathogen with increasing antibiotic resistance, creating an urgent need for new therapeutic strategies. We screened 37 pure compounds and 9 herbal extracts for anti-H. pylori activity and identified be...
A hot origin of dissimilatory sulfite reduction catalyzed by DsrAB in the Paleoarchean Era [0.03%]
太古宙时代DsrAB催化硫酸盐厌氧还原的高温起源
Lingyun Tang,Zhenhao Luo,Shaoming Gao et al.
Lingyun Tang et al.
Dissimilatory sulfite reduction (DSR) has been essential to microbial energy metabolism in the biogeochemical sulfur cycle since the Paleoarchean Era. However, due to the lack of an integrated assessment of geological record and genomic dat...
Changjialian Yang,Luyao Gong,Jing Guo et al.
Changjialian Yang et al.
Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long-standing co-evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review su...
Exploring microorganism-host interactions: Emerging organoid models and analytical approaches [0.03%]
探索微生物与宿主的相互作用：新兴器官体模型和分析方法
Yue Shi,Min Xu,Yanhong Huang et al.
Yue Shi et al.
Microorganisms play a vital role in human health through their interactions with the body. Studies of host-microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid-based models have provided ne...
Profiling the host defense responses against Candida auris in a reliable Drosophila melanogaster infection model [0.03%]
利用可靠的果蝇感染模型剖析芽生酒囊酵母的宿主防御反应
Jie Li,Guangsheng Chen,Xiangkang Zeng et al.
Jie Li et al.
The "superbug" Candida auris has been ranked as a priority fungal pathogen and is becoming a serious threat to public health. However, the underlying mechanisms of real-world pathogen-host interactions remain elusive, in part due to the lac...
CRISPR-based genome editing reveals the roles of efflux pumps in Mycobacterium abscessus [0.03%]
基于CRISPR的基因组编辑揭示了鸟分枝杆菌中的外排泵的作用
Sishang Li,Aofei Duan,Lanyue Zhang et al.
Sishang Li et al.
Mycobacterium abscessus, one of the most antimicrobial-resistant bacteria, is increasingly recognized as the cause of infections that are difficult to treat. Novel genetic manipulation tools are required to elucidate the biology, pathogenes...
Distinct actomyosin-septin coordination governs conidiation and septation in Verticillium dahliae [0.03%]
尖枝稷炭疽色二孢菌中独特的肌动蛋白-肌球蛋白-.sep复合体调控孢子囊和隔片的形成
Juan Tian,Mengli Pu,Bin Chen et al.
Juan Tian et al.
Conidiation is the primary mode of reproduction in filamentous fungi and is essential for the dispersal of pathogenic species. However, the fundamental cellular mechanisms regulating conidiation in plant pathogenic fungi remain largely unex...