Advancements in extracellular vesicle therapy for neurodegenerative diseases [0.03%]
神经退行性疾病外泌体治疗新进展
Ningyun Hu,Liang Chen,Guoku Hu et al.
Ningyun Hu et al.
Neurodegenerative diseases represent a significant and growing challenge to public health worldwide. Current therapeutic strategies often fall short in halting or reversing disease progression, highlighting the urgent need for novel approac...
Carri S Polick,Tiffany J Braley,Robert Ploutz-Snyder et al.
Carri S Polick et al.
Aim: Childhood stressors can increase adult stress perception and may accumulate over the lifespan to impact symptoms of multiple sclerosis (MS). Growing evidence links childhood stressors (e.g., abuse, neglect) to fatigu...
Daisy L Wilson,Jyoti Ahlawat,Mahesh Narayan
Daisy L Wilson
Carbon nanotubes, an emerging class of carbon nanomaterials, possess tremendous potential for application in biotechnology and biomedicine particularly in neurological disorders. Carbon nanotubes owing to their fascinating properties have t...
Eric Birgbauer
Eric Birgbauer
The central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need. One critical aspect of the CNS is its lack of regeneration, such that damage is ofte...
Rehabilitation for non-motor symptoms for patients with Parkinson's disease from an α-synuclein perspective: a narrative review [0.03%]
从α-突触核蛋白角度论述帕金森病非运动症状康复疗法：综述性文章
Zhaoyang Liu,Jessica Lemus,Irina V Smirnova et al.
Zhaoyang Liu et al.
Parkinson's disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbrain and the loss of dopaminergic neurons wit...
Neuroprotective astroglial response to neural damage and its relevance to affective disorders [0.03%]
神经元损伤引起的神经保护性星形胶质细胞反应及其与情感障碍的关系
José Javier Miguel-Hidalgo
José Javier Miguel-Hidalgo
Astrocytes not only support neuronal function with essential roles in synaptic neurotransmission, action potential propagation, metabolic support, or neuroplastic and developmental adaptations. They also respond to damage or dysfunction in ...
Advancing Diagnosis and Treatment of Niemann-Pick C disease through Biomarker Discovery [0.03%]
通过生物标志物发现推进Niemann-Pick C疾病的诊断和治疗
Xuntian Jiang,Daniel S Ory
Xuntian Jiang
Niemann-Pick C is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the heterogeneous presentation and the early non-specific...
Ta Yuan Chang,Catherine C Y Chang,Taylor C Harned et al.
Ta Yuan Chang et al.
Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), also named as sterol ...
Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases [0.03%]
靶向细胞色素P450 46A1和脑胆固醇24-羟基化治疗神经退行性疾病
Irina A Pikuleva
Irina A Pikuleva
The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by CYP46A1 (cytochrome P450 46A1). Both pathways are tightly coupled and dete...
Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease [0.03%]
求同存异：磷脂PIP2和PIP3信号在神经元健康与疾病中的作用
Kamran Tariq,Bryan W Luikart
Kamran Tariq
Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeostasis of phosphatidylinositol 4,5-bisphos...