Monitoring and treatment of alcohol use disorder: an integrated multidisciplinary model [0.03%]
酒精使用障碍的监测和治疗：一种综合多学科模式
Ashwani K Singal
Ashwani K Singal
Alcohol-associated liver disease (ALD) is one of the most prevalent liver diseases and a leading indication for liver transplantation (LT). Alcohol use disorder (AUD), commonly present in patients with ALD, may also be associated with psych...
Fernando Bril
Fernando Bril
This commentary discusses the results of a study that assessed the relationship between homocysteine metabolism and histological severity of metabolic dysfunction-associated steatotic liver disease (MASLD), and applied a mathematical model ...
Insulin increases type I collagen synthesis in hepatic stellate cells via α5β1 integrin [0.03%]
胰岛素通过α5β1整合素增加肝星状细胞I型胶原合成
Milan Dodig,Min Li,Srinivasan Dasarathy et al.
Milan Dodig et al.
Aim: A direct effect of insulin on the synthesis of extracellular matrix proteins has been described in extrahepatic organs. The current study investigates the role of insulin in type I collagen production in hepatic stel...
Cell-specific regulation of insulin action and hepatic fibrosis by CEACAM1 [0.03%]
CEACAM1对胰岛素作用和肝纤维化的细胞特异性调节
Basel G Aldroubi,John A Najjar,Tya S Youssef et al.
Basel G Aldroubi et al.
The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has reached an epidemic rise worldwide. The disease is a constellation of a broad range of metabolic and histopathologic abnormalities. It begins with hepatic...
Fructose as a novel nutraceutical for acetaminophen (APAP)-induced hepatotoxicity [0.03%]
果糖作为治疗对乙酰氨基酚引起的肝毒性的新型营养药品
Kyle Rodrigues,Rawdat Hussain,Sarah Cooke et al.
Kyle Rodrigues et al.
Acetaminophen (APAP) is the most widely used analgesic in the world. APAP overdose can cause severe hepatotoxicity and therefore is the most common cause of drug-induced liver injury. The only approved treatment for APAP overdose is N-acety...
Diminished function of cytotoxic T- and NK- cells in severe alcohol-associated hepatitis [0.03%]
重症酒精性肝炎患者细胞毒性T细胞和自然杀伤细胞功能减退
Adam Kim,Christina K Cajigas-Du Ross,Jaividhya Dasarathy et al.
Adam Kim et al.
Aim: Metabolic liver diseases, including alcohol- and non-alcoholic fatty liver diseases (ALD/NAFLD), are characterized by inflammation and decreased ability to prevent infections. Patients with severe alcohol-associated ...
Major adverse foot events and functional mobility deficits associated with diabetic neuropathy and nephropathy [0.03%]
糖尿病神经病变和肾病相关的严重足部事件和功能行动障碍
David R Sinacore,Michael A Jones,Paul W Kline
David R Sinacore
Aim: The purpose is to determine the risk ratios (RR) for both major adverse foot events (MAFEs) and the presence of moderate and severe functional mobility deficits in participants with diabetic peripheral neuropathy acr...
Pearls and pitfalls in nonalcoholic fatty liver disease: tricky results are common [0.03%]
非酒精性脂肪肝疾病的陷阱与收获：复杂结果很常见
Brian J Wentworth,Stephen H Caldwell
Brian J Wentworth
Interpretation of diagnostic and surveillance laboratory results and imaging in liver disease is fraught with misinterpretation and/or uncertainty. Nonalcoholic fatty liver disease (NAFLD) represents an ever-growing proportion of liver dise...
Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction [0.03%]
协同因素对NAFLD/NASH和MAFLD的影响：一个解释器官功能障碍病理力学的范例
Amedeo Lonardo,Ashwani K Singal,Natalia Osna et al.
Amedeo Lonardo et al.
Primary nonalcoholic fatty liver disease (NAFLD) is bi-directionally associated with the metabolic syndrome and its constitutive features ("factors": impaired glucose disposal, visceral obesity, arterial hypertension, and dyslipidemia). Sec...
Assessing strategies to target screening for advanced liver fibrosis among overweight and obese patients [0.03%]
评估在超重和肥胖患者中筛查晚期肝纤维化策略的效果
Fernando Bril,Eddison Godinez Leiva,Romina Lomonaco et al.
Fernando Bril et al.
Aim: The optimal screening strategy for advanced liver fibrosis in overweight and obese patients is unknown. The aim of this study is to compare the performance of different strategies to select patients at high risk of a...