Vps501 links sorting nexins to TORC1 regulation in budding yeast [0.03%]
Vps501在酿酒酵母中将排序衔接蛋白与TORC1调节相连接
Jacob H Brock,Muhammad A Rahman,Richard J Chi
Jacob H Brock
The lysosome in animal cells or the vacuole in plant and yeast cells serve as storage and/or recycling depots and their delimiting membranes host signaling events critical for starvation-induced cellular self-eating or macroautophagy/autoph...
Sheng Yan,Jing Li
Sheng Yan
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). Autophagy plays a housekeeping ro...
MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence [0.03%]
MAPK15调控线粒体健康并有助于预防细胞衰老
Lorenzo Franci,Giovanni Inzalaco,Mario Chiariello
Lorenzo Franci
Aberrant production of reactive oxygen species (ROS) from dysfunctional mitochondria leads to oxidative stress and DNA damage, which induces the cellular senescence stress response pathway. This, while exerting strong beneficial suppressive...
SOX6-MAP4K4 pathway induces autophagy and contributes to the reduced chemosensitivity of cervical cancer [0.03%]
SOX6-MAP4K4信号通路诱导宫颈癌细胞自噬并降低其化疗敏感性
Hongxin Huang,Jie Wang
Hongxin Huang
Some cervical cancer patients show poor response to neoadjuvant chemotherapy. Although it has been demonstrated that macroautophagy/autophagy contributes to the poor chemosensitivity, the underlying mechanism has not yet been fully clarifie...
Autophagy regulates endosymbiont distribution in early Drosophila embryogenesis [0.03%]
自噬作用调节果蝇胚胎发育早期细胞器的分布
Anton Strunov,Katy Schmidt,Martin Kapun et al.
Anton Strunov et al.
Regulation of Mitochondrial Homeostasis and Metabolic Programming in Memory B cells by Mitophagy [0.03%]
线粒体自噬对记忆B细胞的线粒体稳态及代谢编程的调节作用
Marietta M Budai,Min Li,Srikanth Kodali et al.
Marietta M Budai et al.
The formation of long-lived immune memory cells specific for pathogens is critical for the establishment of long-term immune protection against future infections. BNIP3L/NIX and BNIP3, two functionally redundant BCL2 family members required...
Macrophages produce PGE2 to promote hepatic stellate cell autophagy and liver fibrosis [0.03%]
巨噬细胞产生PGE2促进肝星状细胞自噬和肝纤维化生成
Liuluan Zhu,Yanxi Zhou,Rui Li et al.
Liuluan Zhu et al.
The pathogenesis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) remains unclear and the effective treatments have not been explored yet. The activation of hepatic stellate cells (HSCs) is the most critical factor in the progr...
Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast [0.03%]
硫缺乏条件下裂殖酵母中CDC13（CYCLIN B）通过自噬途径降解
Hokuto Ohtsuka,Yoshiko Hatta,Kana Hayashi et al.
Hokuto Ohtsuka et al.
Cyclins are degraded by the anaphase-promoting complex/cyclosome (APC/C)-mediated proteasome in normal mitosis. We showed that Cdc13 (cyclin B) is also degraded by macroautophagy/autophagy in sulfur-deficient fission yeast. Sulfur depletion...
The role of autophagy in the Arabidopsis self-incompatible pollen rejection response [0.03%]
自噬在拟南芥self-incompatible花粉排斥反应中的作用
Stuart R Macgregor,Daphne R Goring
Stuart R Macgregor
In plants, macroautophagy/autophagy is an essential mechanism responsible for a large variety of processes throughout the plant's lifecycle, including nutrient processing, immunity, stress responses and senescence. Previous studies had obse...
Loss of nuclear envelope bud formation leads to mitophagy initiation in Drosophila muscles [0.03%]
果蝇肌肉中核被膜芽形成丧失导致线粒体自噬发起
Yungui Guo,David Brooks,Ziwei Zhao et al.
Yungui Guo et al.
Pavarotti (Pav) and its binding partner Tumbleweed (Tum) are well known for their evolutionarily conserved roles in microtubule-dependent movements during cytokinesis. In post-mitotic pav RNAi muscles, we unexpectedly observed the accumulat...