Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy [0.03%]
依赖于帕金的线粒体自噬通过依次靶向不同的线粒体亚组分进行自噬的蛋白酶体依赖性步骤发生
Anna Lechado-Terradas,Sandra Schepers,Katharina I Zittlau et al.
Anna Lechado-Terradas et al.
PINK1/parkin-dependent mitophagy initially involves (phospho)ubiquitin-directed proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and the recruitment of autophagy adaptors to a group o...
Yan Zhou,Wei Wu
Yan Zhou
Sulforaphane and its metabolites (SFNs) cause apoptosis in cancers and could be potential anti-cancer drugs. We focused on investigating the underlying mechanisms through which SFNs inhibit cancers. First, SFNs cause microtubule disruption ...
Let them eat virus: exploring how TBK1 (TANK binding kinase 1) enhances autophagic flux to promote autophagic degradation of coxsackievirus B [0.03%]
让他们感染病毒：TBK1(TANK结合激酶1)通过增强自噬流促进柯萨奇B病毒感染的自我降体研究
Savannah Sawaged,Jon Sin
Savannah Sawaged
Coxsackievirus B (CVB) is a common human enterovirus that can cause an array of systemic inflammatory diseases. We and others have demonstrated that macroautophagy/autophagy is activated during CVB infection leading to viral engulfment with...
The role of reticulophagy under early phase phosphate starvation in plant cells [0.03%]
植物细胞早期磷饥饿期间网状体吞噬的作用
Yushi Yoshitake,Kohki Yoshimoto
Yushi Yoshitake
Inorganic phosphate (Pi) is one of the most important nutrients for plant growth. Under Pi starvation, intracellular components are degraded for Pi recycling in plant cells. Macroautophagy/autophagy is a process for vacuolar degradation of ...
The importance of TP53/p53 in regulating the mitophagy-lysosomal machinery in muscle following disuse [0.03%]
TP53/p53在失用后调节肌肉线粒体自噬-溶酶体装置中的重要性
Jonathan M Memme,Ashley N Oliveira,David A Hood
Jonathan M Memme
Since being discovered in the late 1990s, TP53/TRP53/p53 has been a focal point of research, lauded for its role as a tumor-suppressor protein. Considerable attention has also been devoted to understanding how TP53 regulates metabolic progr...
Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish [0.03%]
自噬通过调节斑马鱼软骨细胞分化精细调控关节发育精度
Joanna J Moss,Martina Wirth,Sharon Tooze et al.
Joanna J Moss et al.
Cartilage is a crucial component of the developing and functioning skeleton. It establishes a template for bone formation and comprises the articular cartilage for smooth joint movement. It is formed by dedicated matrix-secreting cells (cho...
PURPL directly modulates ULK1 phosphorylation to inhibit autophagic cell death [0.03%]
PURPL通过直接调节ULK1磷酸化来抑制细胞自噬性死亡
Xiaoting Liang,Liang Zhou
Xiaoting Liang
Autophagic cell death is characterized by uncontrolled macroautophagy/autophagy overactivation. Yet, the key modulators involved in autophagic cell death remain underexplored. In this study, PURPL (p53 upregulated regulator of p53 levels) i...
Favorably against the odds - autophagy control despite advanced amyloid- ß toxicity [0.03%]
出人意料的自噬调控能力——淀粉样蛋白-β毒性加重下的稳态维护
Claudia M Ntsapi,Andre du Toit,Ben Loos
Claudia M Ntsapi
Alzheimer disease (AD) is a devastating condition associated with loss of proteostasis control and autophagy failure, leading to progressive neuronal cell death. However, the relationship between the activity in macroautophagy (MA) and chap...
Reprogramming endo-lysosomal proteostasis disease stress by UBR1- and arginylation-driven endophagy and autophagy protein quality control [0.03%]
由UBR1和精氨酰化驱动的内自噬和自噬蛋白质量控制重编程溶酶体稳态疾病压力
Ben B Wang,Pirjo M Apaja
Ben B Wang
Protein quality control (PQC) is a conformational surveillance system critical to maintaining native protein composition in the cell. However, PQC mechanisms at the endo-lysosomal pathway especially toward membrane proteins and during cumul...
LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins? [0.03%]
LC3相关吞噬作用：泛素化膜蛋白的一种分选机制吗？
Femmy C Stempels,Geert van den Bogaart
Femmy C Stempels
The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is...