VEGF (vascular endothelial growth factor) provides antimicrobial effects via autophagy and lysosomal empowerment in endothelial cells [0.03%]
血管内皮生长因子通过自噬和溶酶体活化在血管内皮细胞中产生抗菌作用
Shiou-Ling Lu,Takeshi Noda
Shiou-Ling Lu
Xenophagy is an intracellular defense mechanism against invading pathogens. Streptococcus pyogenes (group A Streptococcus, GAS) is efficiently eliminated by this process in epithelial cells. However, we previously reported that the efficacy...
Veronica Cocetta,Caterina Vianello,Marta Giacomello et al.
Veronica Cocetta et al.
A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma [0.03%]
靶向胶质母细胞瘤STAT3和自噬的新型联合治疗新策略
Sujoy Bhattacharya,Lawrence M Pfeffer,Edward Chaum
Sujoy Bhattacharya
The aggressive brain cancer glioblastoma (GBM) is notoriously resistant to radiotherapy and chemotherapy, which drives tumor recurrence and relapse. GBM cells are highly addicted to STAT3 (signal transducer and activator of transcription 3)...
The missing link: TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry [0.03%]
缺失的环节：TBK1在腺病毒进入时将膜损伤感知与自噬反应连接在一起
Coralie F Daussy,Noémie Pied,Fabienne Rayne et al.
Coralie F Daussy et al.
Most cell entry by invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol. This process frequently inflicts membrane damage and provokes a cellular response. This Autopha...
snz/SNX25 at the crossroad of endocytosis and lipid handling in autophagy [0.03%]
自噬中的内吞作用和脂质处理的交汇点SNZ/SNX25
Annie Lauzier,Steve Jean
Annie Lauzier
Macroautophagy/autophagy is coupled to a myriad of intracellular processes, among which vesicular trafficking is an important contributor of membranes and proteins required at various stages, from autophagosome formation to degradation. Hen...
Tao Zhang,Yu-Hang Sui,Guan-Qun Li et al.
Tao Zhang et al.
Dysfunction of macroautophagy/autophagy has been demonstrated to contribute to multiple fibrotic diseases. In a recent study, we show that lnc-PFAR, a fibrotic-related lncRNA, is upregulated in human chronic pancreatitis tissues and mouse m...
Zinc dyshomeostasis in secretory compartments promotes tumor growth and invasion via cell autonomous and non-autonomous autophagy [0.03%]
分泌室中的锌稳态失调通过自主和非自主自噬促进肿瘤生长和侵袭
Jiajia Gao,Xuekai Ma,Tao Qu et al.
Jiajia Gao et al.
Many zinc transporters have been found to play important roles in human cancers, but the detailed regulatory mechanism have yet to be well identified. Recently, utilizing Drosophila tumor models, we showed that ZnT86D/dZnT7, a zinc transpor...
Hyeong-Reh C Kim,Abdo J Najy,Seongho Kim et al.
Hyeong-Reh C Kim et al.
Cell survival depends on dynamic interactions among the signaling pathways that control the endoplasmic reticulum (ER) stress response, macroautophagy/autophagy and apoptotic cell death. Our recent study reported an association of cytoplasm...
A novel region within a conserved domain in ATG7 emerged in vertebrates [0.03%]
一个新的区域在ATG7的保守区内于脊椎动物中产生
Valgerdur J Hjaltalin,Vivian Pogenberg,Kevin Ostacolo et al.
Valgerdur J Hjaltalin et al.
The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is a highly conserved degradation pathway important for maintaining homeostasis in eukaryotic cells. Here, we study the evolution of E1...
Autophagy inactivation in osteosarcoma leads to the appearance of poor prognosis-associated factors [0.03%]
成骨肉瘤中自噬失活导致预后不良相关因素的出现
Olivier Camuzard,Marie Nollet,Sabine Santucci-Darmanin et al.
Olivier Camuzard et al.
Osteosarcoma (OS) is a bone cancer exhibiting a 20% survival rate for metastatic patients, which motivates the development of new therapeutic options. Among the various new treatment approaches, modulation of autophagy is the subject of ris...