The two-domain architecture of LAMP2A within the lysosomal lumen regulates its interaction with HSPA8/Hsc70 [0.03%]
LAMP2A的两结构域架构调控其与HSPA8/Hsc70在溶酶体腔内的相互作用
Yuta Ikami,Kazue Terasawa,Tetsuro Watabe et al.
Yuta Ikami et al.
Chaperone-mediated autophagy (CMA) is a unique proteolytic pathway, in which cytoplasmic proteins recognized by HSPA8/Hsc70 (heat shock protein 8) are transported into lysosomes for degradation. LAMP2A (lysosomal-associated membrane protein...
Multiple weak interactions through intrinsically disordered regions mediate the recruitment of Atg9 vesicles by Atg11 to the PAS [0.03%]
多个通过内在无序区域的弱相互作用介导Atg11在PAS募集Atg9囊泡
Nicolas Coudevylle,Verena Baumann,Sascha Martens
Nicolas Coudevylle
Role of diacylglycerol kinase in autophagy, ER biogenesis, and triterpene metabolism [0.03%]
二酰基甘油激酶在自噬、内质网生物发生和三萜代谢中的作用
Kalyani Sai Reju,Chaithra Priya S,Ravi Manjithaya et al.
Kalyani Sai Reju et al.
Saccharomyces cerevisiae is widely used for producing various triterpenes by exploiting its native mevalonate/ergosterol pathway. Yeasts that accumulate phospholipids can produce more triterpenes. Our recent study demonstrated that a high p...
Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy [0.03%]
丙型肝炎病毒NS5A蛋白通过内体微自噬促进二酰基甘油O酰基转移酶1(DGAT1)的溶酶体降解
Putu Yuliandari,Chieko Matsui,Lin Deng et al.
Putu Yuliandari et al.
Many viruses often use a protein degradation system (e.g., the ubiquitin-proteasome pathway or lysosome pathway) to modulate viral propagation and viral pathogenesis. We reported that hepatitis C virus (HCV) infection promotes the lysosomal...
Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux [0.03%]
高通量图像筛选自噬流的强力诱导剂雌酚酮、伞花烃和噻氧alone的鉴定
Surendra Kumar Prajapat,Chandru Subramani,Puja Sharma et al.
Surendra Kumar Prajapat et al.
Autophagy is a conserved intracellular degradation pathway that is essential for maintaining cellular homeostasis. Given its critical role in several disease conditions, recent studies are focussed on identifying drugs/small molecules with ...
Novel insights into the molecular mechanism of amphisome-lysosome fusion [0.03%]
关于氨皮osomes-溶酶体融合分子机制的新见解
Yukako Oe,Tamotsu Yoshimori,Shuhei Nakamura
Yukako Oe
TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB [0.03%]
TFEBexplorer：一个用于研究压力响应型转录因子EB调控基因的集成工具
Rossella De Cegli,Diego Carrella,Diletta Siciliano et al.
Rossella De Cegli et al.
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with...
Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology [0.03%]
考虑ALS-FTD相关SQSTM1/p62突变体以液滴形式致病的机制
Yoshinobu Ichimura,Masaaki Komatsu
Yoshinobu Ichimura
Large numbers of point mutations in SQSTM1/p62 have been identified in amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). SQSTM1 interacts with ubiquitinated proteins, undergoing liquid-liquid phase separation, and t...
RETREG3/FAM134C phosphorylation by CSNK2 regulates reticulophagy during starvation [0.03%]
CSNK2介导的RETREG3/FAM134C磷酸化调节饥饿状态下的网状内质网自噬
Giorgia Di Lorenzo,Francescopaolo Iavarone,Marianna Maddaluno et al.
Giorgia Di Lorenzo et al.
Starvation is the most potent physiological inducer of autophagy, the catabolic process which degrades unessential cytosolic components to sustain cellular homeostasis and survival. During starvation, the mechanisms of autophagy activation ...
Autophagy, a novel player in acetaminophen (APAP)-induced hepatotoxicity [0.03%]
自噬在对乙酰氨基酚(APAP)致肝毒性中的作用
Hui Ye,Francisco Javier Cubero
Hui Ye
Acetaminophen (APAP), a widely used analgesic drug, is safe at therapeutic doses, but can produce significant hepatotoxicity upon overdose. Emerging evidence suggested that endoplasmic reticulum (ER) stress and the unfolded protein response...