The ART of Resistance [0.03%]
抵抗的艺术
Ananya Ray,Namita Surolia
Ananya Ray
Recent emergence and spread of artemisinin (ART) resistance in South-east Asia caused by mutations in P. falciparum Kelch13 in the background of other mutations including mutations in the macroautophagy/autophagy-related protein PfATG18, ha...
Elizabeth McConnaha,Jennifer Giles,Eric Wauson et al.
Elizabeth McConnaha et al.
Macroautophagy/autophagy is a process that degrades unnecessary cellular components to maintain homeostasis. The Ca2+-sensing protein CALM (calmodulin) is needed for many cell functions yet is a limiting factor because of its insufficient a...
Milton Osmar Aguilera,María Isabel Colombo
Milton Osmar Aguilera
Macroautophagy/autophagy is an adaptable pathway involved in the degradation of very different targets that include proteins, organelles, or even invading intracellular microorganisms. The regulation of this complex pathway depends on a gre...
Zuleika C L Leung,Hailey L M Hunter,Basim Abu Rafea et al.
Zuleika C L Leung et al.
Autophagy is an essential cellular degradation pathway in the mammalian preimplantation embryo. In this review, the process of autophagy is outlined and its function pertaining to preimplantation embryos is discussed. The current methods of...
STX17: an ancient SNARE protein whose roles have not been conserved [0.03%]
STX17：一种作用未被保存的古老SNARE蛋白
Shun Kato,Mitsuo Tagaya
Shun Kato
Mammalian STX17 (syntaxin 17) plays different cellular roles, including in mitochondrial fission, lipid droplet expansion and macroautophagy/autophagy, depending on the nutritional status. STX17 has a long C-terminal hydrophobic domain (CHD...
Autophagy and proliferation are dysregulated in Charcot-Marie-Tooth disease type 2A cells harboring MFN2 (mitofusin 2) mutation [0.03%]
自噬和增殖在携带MFN2突变的CMT2A细胞中失调
Paola Zanfardino,Vittoria Petruzzella
Paola Zanfardino
MFN2 (mitofusin 2) is a mitochondrial outer membrane protein that serves primarily as a mitochondrial fusion protein, which is its best known role but has additional functions in regulating cell biological processes. Multiple functions incl...
Valentin J A Barthet,Kevin M Ryan
Valentin J A Barthet
Macroautophagy/autophagy is a conserved catabolic process that delivers intracellular materials to lysosomes for degradation. This process promotes cell survival by maintaining cellular homeostasis and supplying substrates to produce energy...
Proteaphagy and the Trafficking of Proteasomes under Nutrient Stress Conditions [0.03%]
营养胁迫条件下的蛋白酶体的转运和降解蛋白质的作用
Kenrick A Waite,Jeroen Roelofs
Kenrick A Waite
GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid [0.03%]
营养必须氨基酸短暂缺乏时GCN2诱导自噬反应
Anne-Catherine Maurin,Laurent Parry,Wafa B&#x;chir et al.
Anne-Catherine Maurin et al.
The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations. Our previous...
Junya Hasegawa,Ken Inoki,Lois S Weisman
Junya Hasegawa
TFEB (transcription factor EB) is essential for the upregulation of gene expression required for macroautophagy/autophagy and lysosomal function. Under nutrient-rich conditions, TFEB is inactivated by MTOR (mechanistic target of rapamycin k...