Ken Cadwell,Clara Abraham,Shai Bel et al.
Ken Cadwell et al.
Autophagy is an evolutionarily conserved cellular process that is prominent during bacterial infections. In this review article, we discuss how direct pathogen clearance via xenophagy and regulation of inflammatory products represent dual f...
Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity [0.03%]
ATG9A肝细胞功能及内稳态受损的机制研究
Elodie Mailler,Asmita Singh,Michal Jarnik et al.
Elodie Mailler et al.
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional Atg9a knockout (Atg9a-cKO) mouse model, we un...
Chaperone-mediated autophagy dysfunction in imiquimod-induced psoriasiform dermatitis [0.03%]
咪喹莫德诱导的银屑病样皮炎中的伴侣介导的自噬功能障碍
Wei Zhao,Kainan Liao,Wei Song et al.
Wei Zhao et al.
Psoriasis is a chronic inflammatory skin disease characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. Autophagy plays a critical role in regulating the functions of immune cells, endothelial cells, an...
Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond [0.03%]
自噬、亨廷顿病等疾病中的S-乙酰化隔离子1
Y Alshehabi,F Abrar,D D O Martin
Y Alshehabi
Protein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow. Autophagy is a crucial pathway for the removal of protein aggrega...
During Aspergillus nidulans nitrogen-limited biofilm formation, mitophagy is independent of mitochondrial fission [0.03%]
在曲霉菌氮限制生物被膜形成过程中，线粒体自噬独立于线粒体分裂发生
Hari Krishnan Balasubramanian,Stephen A Osmani
Hari Krishnan Balasubramanian
During chronic infections, biofilms are resistant to both antimicrobial agents as well as the host immune system, often giving rise to recalcitrant persister cells with reduced mitochondrial function rendering biofilm infections difficult t...
Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction [0.03%]
人类白细胞中特定类型的自噬作用：衰老、性别和营养限制的标志
Linh Vp Dang,Timothy J Sargeant
Linh Vp Dang
Macroautophagy (referred to here as autophagy) is thought to play a critical role in aging and age-related disease, making it a priority for development of targeted human therapies. We developed a flow cytometry-based method to measure auto...
The role of autophagy in the pathogenesis and treatment of multiple sclerosis [0.03%]
自噬在多发性硬化症发病机制和治疗中的作用
Giulio Righes,Luana Semenzato,Konstantinos Koutsikos et al.
Giulio Righes et al.
Autophagy is a crucial cellular process responsible for the degradation and recycling of damaged or unnecessary components, maintaining cellular homeostasis and protecting against stress. Dysregulation of autophagy has been implicated in a ...
Differential response of neurons to autophagy modulation in Huntington's disease [0.03%]
亨廷顿舞蹈病的小胶质细胞和神经元对自噬调节的不同反应
Ankit Sharma,Sushma Rao,Ravi Manjithaya et al.
Ankit Sharma et al.
Huntington's disease (HD) is caused by the expansion of poly-glutamine repeats in the Huntingtin (Htt) gene and is associated with a wide variety of motor and physiological (sleep, metabolism, etc.) perturbations. Studies from diverse model...
ADP ribosylation factor-like GTPase 6-interacting protein 5 (ARL6IP5): a prenylated Rab acceptor protein 1 (PRA1) family protein that shapes the ER membrane and regulates ER-phagy [0.03%]
ARL6IP5：一种成膜的PRAC家族蛋白，调节自噬受体介导的内质网自噬
Yasunori Yamamoto,Toshiaki Sakisaka
Yasunori Yamamoto
The prenylated Rab acceptor protein 1 (PRA1) domain is a conserved domain encompassing four transmembrane domains (TMDs). ARL6IP5 (ADP ribosylation factor-like GTPase 6-interacting protein 5) is a member of the PRA1 family and interacts wit...
Autophagy-enhancing strategies to promote intestinal viral resistance and mucosal barrier function in SARS-CoV-2 infection [0.03%]
促进自噬以增强肠道抗病毒能力及黏膜屏障功能以应对SARS-CoV-2感染
Anusca G Rader,Alexandra P M Cloherty,Kharishma S Patel et al.
Anusca G Rader et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease 19 (COVID-19), continues to circulate globally despite the widespread vaccination and therapeutics like Paxlovid, remdesivir, and molnu...