The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein [0.03%]
自噬在突触核蛋白病中的作用：α-突触核蛋白的清除与扩散
Emily Birnbaum,Zhenyu Yue
Emily Birnbaum
Emerging evidence suggests that the propagation of α-synuclein pathology underlies the progression of Parkinson's disease and supports the hypothesis that transmission of α-synuclein aggregates contributes to dopaminergic degeneration. Au...
Targeting macroautophagy to combat neurodegenerative disease: strategies and considerations [0.03%]
靶向宏观自噬以对抗神经退行性疾病：策略与考量
Glenn M Duncan,Ai Yamamoto
Glenn M Duncan
Upon demonstration that basal macroautophagy plays an essential role in maintaining protein homeostasis in the mammalian CNS, there has been excitement around modulating this form of autophagy as a therapeutic strategy to combat neurodegene...
The multifaceted role of autophagy and mitophagy in cardiovascular health and disease [0.03%]
自噬和线粒体自噬在心血管健康和疾病中的作用
Mireia Nàger,Mauro Calvoli,Kenneth B Larsen et al.
Mireia Nàger et al.
The cardiovascular system, consisting of the heart and blood vessels, ensures delivery of oxygen and nutrient-rich blood throughout the whole body. The major cell types include cardiomyocytes, endothelial cells, and vascular smooth muscle c...
Influence of skeletal muscle heterogeneity on autophagic signaling and response [0.03%]
骨骼肌异质性对自噬信号传导和反应的影响
Fasih A Rahman,Joe Quadrilatero
Fasih A Rahman
Skeletal muscle is a heterogeneous tissue composed of fibers with distinct contractile, metabolic, and molecular characteristics. This intrinsic heterogeneity influences how individual fibers respond to physiological stimuli, pathological s...
The space-time continuum in neurological disorders of the autophagosome-lysosome fusion machinery [0.03%]
自噬溶酶体融合机制神经障碍的时空连续性研究
Hormos Salimi Dafsari,Juliane Schuler,Emil Schober et al.
Hormos Salimi Dafsari et al.
Autophagy is a highly conserved cellular pathway for the degradation and recycling of defective intracellular cargo and plays a vital role in the homeostasis of post-mitotic tissues, particularly the nervous system. Autophagosome-lysosome f...
Hyungsin Kim,Wenping Wang,Ioana Dobrescu et al.
Hyungsin Kim et al.
Autophagy is a lysosome-directed recycling program that preserves lung homeostasis yet, when dysregulated, can cause disease. This review organizes current evidence by lung compartment and disease phase, proposing that autophagy polarity is...
BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis [0.03%]
BECLIN-1/BECN1在屏障中：上皮和内皮稳态的守门者
Juliani Juliani,Walter D Fairlie,Erinna F Lee
Juliani Juliani
Epithelial and endothelial barriers are essential for tissue homeostasis, protecting the body from environmental insults while regulating selective transport. The integrity of these barriers relies on dynamic intercellular junctions whose c...
Kha M Nguyen,Hannah R Shariati,Calvin K Yip
Kha M Nguyen
The budding yeast Saccharomyces cerevisiae Atg1 complex coordinates the initiation of nonselective autophagy and consists of the Atg1 kinase, Atg13 regulatory subunit, and an S-shaped scaffold formed by Atg17, Atg29, and Atg31. In contrast,...
Mélissa Lallier,Rani Robeyns,Freke Mertens et al.
Mélissa Lallier et al.
Targeting autophagy is believed to hold great promise for the treatment of various diseases, including cancer. However, since the therapeutic efficacy of currently available autophagy-modulating drugs is limited by off-target effects and th...
Samrah Masud,Jiajun Xie,Bart J M Grijmans et al.
Samrah Masud et al.
DRAM1 is an infection inducible autophagy modulator, previously shown to promote autophagic and lysosomal defense responses against the intracellular pathogen Mycobacterium marinum. However, its possible role in other anti-bacterial autopha...