Role of neuronal fabp in autophagy and amyloid-β pathology in a Drosophila model of Alzheimer disease [0.03%]
神经元fabp在阿尔茨海默病果蝇模型自噬和淀粉样蛋白病理中的作用
Byoungyun Choi,Kyoung Sang Cho
Byoungyun Choi
FABP3 and FABP7 are members of the fatty acid-binding protein (FABP) family that transport fatty acids to intracellular organelles, which are elevated in patients with Alzheimer disease (AD). However, their role in the disease pathogenesis ...
Autophagy in alzheimer disease pathogenesis and its therapeutic values [0.03%]
自噬在阿尔茨海默病发病机制中的作用及其治疗价值
Gabrielle Angst,Nuo Jia,Luis E Tron Esqueda et al.
Gabrielle Angst et al.
Alzheimer disease (AD) is the most common form of dementia with hallmarks of β-amyloid deposits, neurofilament tangles, synaptic loss and neuronal death in the patient's brain. AD is a heavy burden in an ageing society as there are no effe...
Aiswarya Raj,Samantha Shrihari,Urmi Bandyopadhyay
Aiswarya Raj
Cellular homeostasis depends on a multitude of cellular functions, which in turn depend on the clearance of damaged components for their maintenance. Lysosomes being one of the main sites of recycling, are at the frontline for cellular prot...
Positional specialization of LIR motifs in RavZ and the autophagy-related protein ATG4B [0.03%]
RavZ的LIR基序定位专业化及其与自噬相关蛋白ATG4B的比较
Sang-Won Park,Jin-A Lee,Deok-Jin Jang
Sang-Won Park
LC3-interacting region (LIR) motifs are essential for recruiting proteins onto autophagosomes, the hallmark of autophagy. We recently explored the relevance of the specific position of the LIRs in RavZ and ATG4B (autophagy-related 4B). RavZ...
Metamorphosis and development of malaria parasites in the liver are regulated by unconventional autophagy [0.03%]
异常自噬调节疟原虫肝内发育及裂变生殖
Suryansh Rajput,Satish Mishra
Suryansh Rajput
Malaria parasites encounter diverse conditions as they transition between mosquito and mammalian hosts. A characteristic of the sporozoite stage of the parasite is that once it enters the hepatocyte, it changes its morphology and metabolism...
Evidence of the specific roles of autophagy in senescent leaves and maturing seeds [0.03%]
自噬在衰老叶片和成熟种子中特异性作用的证据
Anne Marmagne,Fabien Chardon,Céline Masclaux-Daubresse
Anne Marmagne
In plants, a large part of the nutrients used to generate seed lipid and protein reserves is derived from both the degradation of macromolecules in source leaves and the transfer of small catabolic molecules like amino acids from the senesc...
Emily Osterli,Yujung Park,Kurt Hu et al.
Emily Osterli et al.
Ischemic brain injury occurs in many clinical settings, including stroke, cardiac arrest, hypovolemic shock, cardiac surgery, cerebral edema, and cerebral vasospasm. Decades of work have revealed many important mechanisms related to ischemi...
Untangling Traffic Jams: RAB11FIP4 Orchestrates Cellular Recovery in Cystinosis [0.03%]
解开交通拥堵：RAB11FIP4在胱氨酸症中协调细胞恢复
Mouad Ait Kbaich,Jennifer L Johnson,Sergio D Catz
Mouad Ait Kbaich
RAB11FIP4 (RAB11 family interacting protein 4), a RAB11A (Ras-related protein Rab-11) effector protein downregulated in cystinosis, plays a crucial role in cellular trafficking. Reconstitution of RAB11FIP4 in cystinotic cells restores multi...
Tropheryma whipplei escapes LAPosome and modulates macrophage response in a xenophagy-dependent manner [0.03%]
Tropheryma whipplei 通过依赖于细胞自噬的方式逃逸LAPosome并调节巨噬细胞的反应
Emilie Reyne,Jeffrey Arrindell,Eloïne Bestion et al.
Emilie Reyne et al.
Tropheryma whipplei, the agent of Whipple's disease, is an intracellular pathogen that replicates in macrophages. The phagocytic and cellular processes leading to the formation of T. whipplei replicative vacuole remain poorly understood. Ma...
Identification of a novel mechanism for regulation of the early autophagy machinery assembly by PKA [0.03%]
PKA调节早期自噬机器组装的新机制的鉴定
Miranda Bueno-Arribas,Olivier Vincent
Miranda Bueno-Arribas
The E3-like complex Atg12-Atg5-Atg16, which promotes Atg8 lipidation, is recruited to the autophagosomal membrane through the interaction of Atg16 with the PROPPIN/WIPI protein Atg21, as well as by the binding of Atg12 to Atg17, the scaffol...