In silico investigation of binding affinities between human leukocyte antigen class I molecules and SARS-CoV-2 virus spike and ORF1ab proteins [0.03%]
人白细胞抗原I类分子与SARS-CoV-2病毒刺突蛋白和ORF1ab蛋白结合亲和力的计算研究
Spyros A Charonis,Effie-Photini Tsilibary,Apostolos P Georgopoulos
Spyros A Charonis
Aim: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019, a global pandemic. There is hence an urgent need for effective approaches to understand the mechanis...
Do endometrial immune changes with age prior to menopause compromise fertility in women? [0.03%]
绝经前子宫内膜随着年龄增长而产生的免疫改变会损害女性生育力吗？
Mickey V Patel,Zheng Shen,Charles R Wira
Mickey V Patel
Menopause signals the end of the reproductive period in women. However, fertility and fecundity decrease with increasing age prior to menopause demonstrating that changes in the premenopausal female reproductive tract (FRT) are already occu...
Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages [0.03%]
线粒体功能障碍加剧衰老巨噬细胞炎症反应
Rafael Moura Maurmann,Brenda Landvoigt Schmitt,Negin Mosalmanzadeh et al.
Rafael Moura Maurmann et al.
Immunosenescence encompasses multiple age-related adaptations that result in increased susceptibility to infections, chronic inflammatory disorders, and higher mortality risk. Macrophages are key innate cells implicated in inflammatory resp...
Allogeneic gamma delta T cells as adoptive cellular therapy for hematologic malignancies [0.03%]
同种异体的gamma delta T细胞在血液系统恶性肿瘤过继细胞治疗中的应用
Navdeep Jhita,Sunil S Raikar
Navdeep Jhita
Cancer immunotherapy, especially T-cell driven targeting, has significantly evolved and improved over the past decade, paving the way to treat previously refractory cancers. Hematologic malignancies, given their direct tumor accessibility a...
Joseph M McGraw,Deborah A Witherden
Joseph M McGraw
Antitumor immunity relies on the ability of T cells to recognize and kill tumor targets. γδ T cells are a specialized subset of T cells that predominantly localizes to non-lymphoid tissue such as the skin, gut, and lung where they are act...