Systemic delivery of large-scale manufactured Wharton's Jelly mesenchymal stem cell-derived extracellular vesicles improves cardiac function after myocardial infarction [0.03%]
规模化制备的沃顿氏凝胶间充质干细胞源外泌体系统给药改善心肌梗死后心脏功能
Michael A Bellio,Rosemeire M Kanashiro-Takeuchi,Lauro Takeuchi et al.
Michael A Bellio et al.
Introduction: Cardiovascular disease and myocardial infarction are leading causes of morbidity and mortality in aged populations. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are under evaluation as a ...
Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy? [0.03%]
利用间歇性限时进食增强昼夜节律自噬：一种新的抗衰老策略吗？
Sebastiano Sciarretta,Maurizio Forte,Junichi Sadoshima
Sebastiano Sciarretta
Effects of tamoxifen inducible MerCreMer on gene expression in cardiac myocytes in mice [0.03%]
他莫西芬诱导的MerCreMer对小鼠心脏成肌细胞基因表达的影响
Leila Rouhi,Siyang Fan,Sirisha M Cheedipudi et al.
Leila Rouhi et al.
The Cre-LoxP technology, including the tamoxifen (TAM) inducible MerCreMer (MCM), is increasingly used to delineate gene function, understand the disease mechanisms, and test therapeutic interventions. We set to determine the effects of TAM...
Natalie A Gude,Fareheh Firouzi,Mark A Sussman
Natalie A Gude
Emma L Robinson,Timothy A McKinsey
Emma L Robinson
Severe systemic inflammation in COVID-19 patients can lead to dysfunction of multiple organs, including the heart. Using an ex vivo cardiac organoid system, Mills et al discovered that inhibitors of the chromatin reader protein, bromodomain...
Oligogenic cardiomyopathy [0.03%]
寡基因性心肌病
Ali J Marian
Ali J Marian
GSNOR regulates cardiomyocyte differentiation and maturation through protein S-nitrosylation [0.03%]
GSNOR通过蛋白质S-亚硝基化调控心肌细胞的分化和成熟
Zachary W Grimmett,Nicholas M Venetos,Richard T Premont et al.
Zachary W Grimmett et al.
S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme responsible for reverting protein S-nitrosylation (SNO). In this issue, Salerno et al. [1] provide evidence that GSNOR deficiency - and thus elevated protein S-nitrosylation -...
S-nitrosoglutathione reductase (GSNOR) deficiency accelerates cardiomyocyte differentiation of induced pluripotent stem cells [0.03%]
S-亚硝基谷胱甘肽还原酶(GSNOR)缺乏加速诱导多能干细胞的心肌细胞分化
Alessandro G Salerno,Amarylis C B A Wanschel,Raul A Dulce et al.
Alessandro G Salerno et al.
Introduction: Induced pluripotent stem cells (iPSCs) provide a model of cardiomyocyte (CM) maturation. Nitric oxide signaling promotes CM differentiation and maturation, although the mechanisms remain controversial. ...
A combinatorial oligogenic basis for the phenotypic plasticity between late-onset dilated and arrhythmogenic cardiomyopathy in a single family [0.03%]
单个家族晚期扩张型和心律失常型心肌病表型可塑性的组合寡基因基础
Kimia Pourebrahim,John Garrity Marian,Yanli Tan et al.
Kimia Pourebrahim et al.
Introduction: Primary dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC) are the two common and distinct forms of hereditary cardiomyopathies caused by defined pathogenic variants (PVs...