Age-related cardiovascular disease and mosaic hematopoietic loss of the Y chromosome [0.03%]
与年龄相关的心血管疾病和造血干细胞Y染色体丢失的镶嵌现象
Nicholas W Chavkin
Nicholas W Chavkin
Age is the strongest risk factor for cardiovascular morbidity and mortality, driven in part by aging leukocytes negatively impact cardiovascular health. This effect is particularly pronounced in men, who have a shorter average lifespan-appr...
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters [0.03%]
表观遗传调控心脏生理和病理生理：性别有差异
Omid M T Rouzbehani,Marta W Szulik,Clint Gwynn et al.
Omid M T Rouzbehani et al.
Cardiovascular disease (CVD) is the leading cause of global morbidity and mortality, with epigenetic mechanisms playing a pivotal role in its pathogenesis. This review synthesizes current evidence on sex-specific epigenetic regulation in ca...
Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions [0.03%]
心血管老化中生物有效氮氧化物的下降：机制见解和新兴干预措施
Hriju Adhikari,Priyanka Patel,Namratha Javvaji et al.
Hriju Adhikari et al.
Nitric oxide (NO) is essential for maintaining normal cardiovascular function, and accumulating evidence suggests that its diminished bioavailability contributes to endothelial dysfunction, vascular stiffening, and impaired cardiac performa...
Role of plasminogen activator inhibitor-1 (PAI-1) in age-related cardiovascular pathophysiology [0.03%]
plasminogen激活物抑制剂-1(PAI-1)在与年龄有关的心血管病理生理学中的作用
Alireza Khoddam,Douglas Vaughan,Lisa Wilsbacher
Alireza Khoddam
Cardiovascular aging underpins the development of age-related diseases, including heart failure and vascular dysfunction, and is driven by molecular and cellular mechanisms described in the hallmarks of aging. Plasminogen activator inhibito...
Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies [0.03%]
细胞衰老诱导血管衰老的机制：针对衰老疗法的证据
Sophia A Mahoney,Samuel I Bloom,Douglas R Seals et al.
Sophia A Mahoney et al.
Cardiovascular diseases (CVD) remain the leading cause of death worldwide, with advancing age being the primary, nonmodifiable risk factor. Vascular dysfunction, namely arterial stiffening and endothelial dysfunction, is the key antecedent ...
Dylan J Gyberg,Ravi B Patel,Michael J Zhang
Dylan J Gyberg
Aging is a primary driver of atrial remodeling and dysfunction, and contributes to the increasing prevalence of atrial myopathy in the aging population. Atrial myopathy, characterized by structural, functional, and electrophysiological abno...
Aging diastole - root cause for atrial fibrillation and heart failure with preserved ejection fraction [0.03%]
衰老导致的舒张功能障碍-房颤和射血分数保留型心力衰竭的根本原因
Markus Meyer,Julio Núñez,Parag Goyal et al.
Markus Meyer et al.
The age-related decline in diastolic function can result in heart failure with a preserved ejection fraction (HFpEF) and atrial fibrillation (AF), which are comorbid conditions that are increasingly prevalent and have a high socioeconomic b...
Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential [0.03%]
房颤进展的老化相关机制及其治疗潜力
Shuai Zhao,Aaron M Johnston,Chi Him Kendrick Yiu et al.
Shuai Zhao et al.
Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in the elderly. As the global aging population rapidly expands, it is increasingly important to examine how alterations to the aging heart...
The aging heart: exploring the role of Klotho in cardiac health/function [0.03%]
衰老与心脏：探讨克洛托在心脏健康及功能方面的作用
Nastaran Daneshgar,Dao-Fu Dai,Chad E Grueter
Nastaran Daneshgar
This review discusses the pathophysiological changes associated with cardiac aging and the potential therapeutic role of the anti-aging protein Klotho. It highlights key contributors to heart failure, such as arterial stiffening, myocardial...
Impact of Myocardial Infarction on Cerebral Homeostasis: Exploring the Protective Role of Estrogen [0.03%]
心肌梗死对脑内稳态的影响：探讨雌激素的保护作用
Lana El-Samadi,Rana Zahreddine,Joanna A Ziade et al.
Lana El-Samadi et al.
Myocardial infarction (MI), commonly known as a heart attack, results from the rupture of atherosclerotic plaques in coronary arteries, which triggers a series of pathological events including cardiomyocyte death, thrombus formation, and sy...