Chia-Feng Liu,W H Wilson Tang
Chia-Feng Liu
Sarcopenia is common in aging and in patients with heart failure (HF) who may experience worse outcomes. Patients with muscle wasting are more likely to experience falls and can have serious complications when undergoing cardiac procedures....
Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications [0.03%]
癌症治疗引起的NAD+耗竭与细胞衰老及远期心血管并发症的关系
Priyanka Banerjee,Elizabeth A Olmsted-Davis,Anita Deswal et al.
Priyanka Banerjee et al.
Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. Senescence-associated secretory phenotype (SASP) can be induced by telome...
Ivan Menendez-Montes,Hesham A Sadek
Ivan Menendez-Montes
Ali J Marian
Ali J Marian
Aging is an archetypical complex process influenced by genetic and environmental factors. Genetic variants impart a gradient of effect sizes, albeit the effect sizes seem to be skewed toward those with small effect sizes. On one end of the ...
Nikolaos G Frangogiannis
Nikolaos G Frangogiannis
The development of novel therapies based on understanding the pathophysiologic basis of disease is a major goal of biomedical research. Despite an explosion in new knowledge on the molecular mechanisms of disease derived from animal model i...
Fang Cao,Richard T Lee
Fang Cao
Optimization of tamoxifen-induced gene regulation in cardiovascular research [0.03%]
心血管研究中托美afort诱导的基因调控优化
Abitha Sukumaran,Sakthivel Sadayappan
Abitha Sukumaran
Aykhan Yusifov,Kathleen C Woulfe,Danielle R Bruns
Aykhan Yusifov
Aging promotes structural and functional remodeling of the heart, even in the absence of external factors. There is growing clinical and experimental evidence supporting the existence of sex-specific patterns of cardiac aging, and in some c...
The sad plight of cell therapy for heart failure: causes and consequences [0.03%]
心力衰竭细胞治疗的悲惨境地：原因和后果
Roberto Bolli,Xian-Liang Tang
Roberto Bolli
The WNT/β-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes [0.03%]
Wnt/β-catenin信号通路调控心肌细胞周期进程及线粒体氧化磷酸化相关基因表达
Melis Olcum,Sirisha M Cheedipudi,Leila Rouhi et al.
Melis Olcum et al.
Introduction: Aging is associated with cardiac myocyte loss, sarcopenia, and cardiac dysfunction. Adult cardiac myocytes are postmitotic cells with an insufficient proliferative capacity to compensate for myocyte loss. Th...