In-depth characterization of a mouse model of postoperative atrial fibrillation [0.03%]
术后房颤小鼠模型的深入特征分析
Joshua A Keefe,Jose Alberto Navarro-Garcia,Li Ni et al.
Joshua A Keefe et al.
Introduction: Postoperative atrial fibrillation (POAF), characterized as AF that arises 1-3 days after surgery, occurs after 30%-40% of cardiac and 10%-20% of non-cardiac surgeries, and is thought to arise due to transien...
Zachary S Clayton,Daniel H Craighead,Sanna Darvish et al.
Zachary S Clayton et al.
The development of age-related cardiovascular (CV) dysfunction increases the risk of CV disease as well as other chronic age-associated disorders, including chronic kidney disease, and Alzheimer's disease and related dementias. Major manife...
Jamie Francisco,Dominic P Del Re
Jamie Francisco
Maha Abdellatif
Maha Abdellatif
Deficient Lmna in fibroblasts: an emerging role of non-cardiomyocytes in DCM [0.03%]
成纤维细胞中LMNA缺陷：非心肌细胞在DCM中的作用不容忽视
Xinjie Wang,Weijia Luo,Jiang Chang
Xinjie Wang
Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype [0.03%]
LMNA基因缺失通过激活双链DNA损伤反应和诱导衰老相关分泌表型引起成纤维细胞中与衰老相关的扩张性心肌病
Leila Rouhi,Gaelle Auguste,Qiong Zhou et al.
Leila Rouhi et al.
Introduction: Mutations in the LMNA gene, encoding Lamin A/C (LMNA), are established causes of dilated cardiomyopathy (DCM). The phenotype is typically characterized by progressive cardiac conduction defects, arrhythmias,...
STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts [0.03%]
用于再生和修复小鼠梗死心脏的STIM1和YAP5SA合成型修饰mRNA
Siyu Xiao,Rui Liang,Emilio Lucero et al.
Siyu Xiao et al.
Introduction: The adult heart lacks the regenerative capacity to self-repair. Serum response factor (SRF) is essential for heart organogenesis, sarcomerogenesis, and contractility. SRF interacts with co-factors, such as N...