Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia [0.03%]
用于治疗儿茶酚胺敏感性多形性室性心动过速的心脏基因组编辑技术的长期有效性和安全性研究
Oliver M Moore,Yuriana Aguilar-Sanchez,Satadru K Lahiri et al.
Oliver M Moore et al.
Introduction: Heterozygous autosomal-dominant single nucleotide variants in RYR2 account for 60% of cases of catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited arrhythmia disorder associated with h...
Hypoxia-induced stabilization of HIF2A promotes cardiomyocyte proliferation by attenuating DNA damage [0.03%]
低氧诱导的HIF2A稳定通过减轻DNA损伤促进心肌细胞增殖
Shah R Ali,Ngoc Uyen Nhi Nguyen,Ivan Menendez-Montes et al.
Shah R Ali et al.
Introduction: Gradual exposure to a chronic hypoxic environment leads to cardiomyocyte proliferation and improved cardiac function in mouse models through a reduction in oxidative DNA damage. However, the upstream transcr...
Cody A Rutledge
Cody A Rutledge
The loss of skeletal muscle, also known as sarcopenia, is an aging-associated muscle disorder that is disproportionately present in heart failure (HF) patients. HF patients with sarcopenia have poor outcomes compared to the overall HF patie...
Turning back time: effects of young plasma on pan epigenetic clocks and implications for the heart [0.03%]
逆转时光：年轻血浆对全景表观遗传钟的影响及其对心脏的含义
Kathleen C Woulfe,Emma L Robinson
Kathleen C Woulfe
Manisha Deogharia,Priyatansh Gurha
Manisha Deogharia
Feng Gao,Benjamin Litchfield,Huaizhu Wu
Feng Gao
Obesity is associated with chronic inflammation in adipose tissue (AT), mainly evidenced by infiltration and phenotypic changes of various types of immune cells. Macrophages are the major innate immune cells and represent the predominant im...
Kalyani Ananthamohan,Julian E Stelzer,Sakthivel Sadayappan
Kalyani Ananthamohan
Hypertrophic cardiomyopathy (HCM) is characterized by abnormal thickening of the myocardium, leading to arrhythmias, heart failure, and elevated risk of sudden cardiac death, particularly among the young. This inherited disease is predomina...
Laura Ben Driss,John Lian,Ryan G Walker et al.
Laura Ben Driss et al.
Since the exogenous administration of GDF11, a TGF-ß superfamily member, was reported to have beneficial effects in some models of human disease, there have been many research studies in GDF11 biology. However, many studies have now confir...
M Bilal Bayazit,Ashley Francois,Erin McGrail et al.
M Bilal Bayazit et al.
Introduction: Mice harboring a D257A mutation in the proofreading domain of the mitochondrial DNA polymerase, Polymerase Gamma (POLG), experience severe metabolic dysfunction and display hallmarks of accelerated aging. We...
Endothelial cell dysfunction: the culprit for cardiac denervation in aging? [0.03%]
内皮细胞功能障碍：心脏去神经支配的罪魁祸首？
Oliver M Moore,Joshua A Keefe,Xander H T Wehrens
Oliver M Moore