Microvascular angiotensin II type 2 receptor function is enhanced in young females and declines in a model of murine aging [0.03%]
小鼠微血管中的血管紧张素II受体功能在年轻雌性中增强而在衰老模型中下降
Casey G Turner,Karla de Oliveira,Qing Lu et al.
Casey G Turner et al.
Introduction: Angiotensin II (AngII) affects cardiovascular health, mediating impacts through AngII type 1 (AT1R) and type 2 (AT2R) receptors. The present study investigated sex and aging-related differences in microvascu...
Aging triggers mitochondrial, endoplasmic reticulum, and metabolic stress responses in the heart [0.03%]
衰老在心脏中触发线粒体、内质网和代谢应激反应
Sakthijothi Muthu,Zinnia Tran,Jayapalraja Thilagavathi et al.
Sakthijothi Muthu et al.
Introduction: Aging is a multifaceted biological process characterized by a progressive decline in cellular and tissue function. It significantly impacts the cardiovascular system and contributes to the onset of cardiovas...
Mariko Aoyagi Keller,Michinari Nakamura
Mariko Aoyagi Keller
Acetyltransferases are enzymes that catalyze the transfer of an acetyl group to a substrate, a modification referred to as acetylation. Loss-of-function variants in genes encoding acetyltransferases can lead to congenital disorders, often c...
Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes [0.03%]
核受体RORα的多甲氧基黄酮调节心肌细胞的细胞存活作用的新机制研究
Yuka Shiheido-Watanabe,Junichi Sadoshima
Yuka Shiheido-Watanabe
Regulators of clonal hematopoiesis and physiological consequences of this condition [0.03%]
克隆造血的调控及这种状态的生理后果
Eunbee Park,Megan A Evans,Kenneth Walsh
Eunbee Park
Clonal hematopoiesis (CH) is a prevalent condition that results from somatic mutations in hematopoietic stem cells. When these mutations occur in "driver" genes, they can potentially confer fitness advantages to the affected cells, leading ...
Shelby A Hall,Lisa A Lesniewski
Shelby A Hall
Aging is a major risk factor for atherosclerosis and cardiovascular disease (CVD). Two major age-associated arterial phenotypes, endothelial dysfunction and large elastic arterial stiffness, are autonomous predictors of future CVD diagnosis...
Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart [0.03%]
心肌细胞衰老及衰老细胞靶向治疗在心脏疾病中的潜在作用
Peiyong Zhai,Junichi Sadoshima
Peiyong Zhai
Cellular senescence in cardiomyocytes, characterized by cell cycle arrest, resistance to apoptosis, and the senescence-associated secretory phenotype, occurs during aging and in response to various stresses, such as hypoxia/reoxygenation, i...
Jie Zhang,Berhanu Geresu Kibret,Dorothy E Vatner et al.
Jie Zhang et al.
There are two major subtypes of adipose tissue, i.e., white adipose tissue (WAT) and brown adipose tissue (BAT). It has been known for a long time that WAT mediates obesity and impairs healthful longevity. More recently, interest has focuse...
Dysfunctional mitochondria elicit bioenergetic decline in the aged heart [0.03%]
功能失调的线粒体导致老年心脏生物能量下降
Pasquale Mone,Esther Densu Agyapong,Giampaolo Morciano et al.
Pasquale Mone et al.
Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this cont...
From vitality to vulnerability: the impact of oxygen on cardiac function and regeneration [0.03%]
从活力到脆弱：氧气对心脏功能和再生的影响
Dogacan Yucel,William T Pu
Dogacan Yucel