Allison B Herman,James R Occean,Payel Sen
Allison B Herman
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity for all sexes, racial and ethnic groups. Age, and its associated physiological and pathological consequences, exacerbate CVD incidence and progression, while modul...
Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy [0.03%]
GSK-3β的Ser9磷酸化通过抑制自噬从而促进心脏老化
Yanbin Chen,Yasuhiro Maejima,Akihiro Shirakabe et al.
Yanbin Chen et al.
Introduction: Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase and a negative regulator of cardiac hypertrophy. Phosphorylation of GSK-3β at Ser9 negatively regulates its kinase activity. The role of G...
Chen Gao,Nancy Cao,Yibin Wang
Chen Gao
Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy [0.03%]
药理学抑制WNT信号通路可减轻致心律失常性心肌病小鼠模型中的年龄依赖性表型表达
Sirisha M Cheedipudi,Siyang Fan,Leila Rouhi et al.
Sirisha M Cheedipudi et al.
Introduction: Arrhythmogenic cardiomyopathy (ACM) is a genetic disease of the myocardium, characterized by cardiac arrhythmias, dysfunction, and sudden cardiac death. The pathological hallmark of ACM is fibro-adipocytes r...
Hematopoietic JAK2V617F-mediated clonal hematopoiesis: AIM2 understand mechanisms of atherogenesis [0.03%]
造血JAK2V617F介导的克隆性造血：AIM2理解动脉粥样硬化发病机制的作用
Soichi Sano,Kenneth Walsh
Soichi Sano
Ali J Marian,Babken Asatryan,Roberto Bolli et al.
Ali J Marian et al.
Adenine base editing to treat progeria syndrome and extend the lifespan [0.03%]
用腺嘌呤碱基编辑治疗早衰综合征并延长寿命
Kiran Musunuru
Kiran Musunuru
Hutchinson-Gilford progeria syndrome (HGPS) is an exceedingly rare and hitherto incurable and fatal disease marked by accelerated aging simultaneously affecting a number of organs. Most cases of HGPS are caused by a single copy of a specifi...
Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure [0.03%]
心力衰竭领域的衰老医学：人类衰老与心力衰竭共通发病机制的治疗靶点探索
Age is a major risk factor for heart failure, but one that has been historically viewed as non-modifiable. Emerging evidence suggests that the biology of aging is malleable, and can potentially be intervened upon to treat age-associated chr...