Oral Bioavailability of a Noncoding RNA Drug, TY1, That Acts on Macrophages [0.03%]
一种作用于巨噬细胞的非编码RNA药物TY1的口服生物利用度
Shukuro Yamaguchi,Kazutaka Miyamoto,Xaviar M Jones et al.
Shukuro Yamaguchi et al.
All approved RNA therapeutics require parenteral delivery. Here, we demonstrate an orally bioavailable formulation wherein synthetic noncoding (nc) RNA, packaged into lipid nanoparticles, is loaded into casein-chitosan (C2) micelles. We use...
Cerebrospinal Fluid-Derived Extracellular Vesicles: A Proteomic and Transcriptomic Comparative Analysis of Enrichment Protocols [0.03%]
脑脊液衍生的细胞外囊泡： enrichment 方法的比较分析
Marta García-Arauzo,Sandrine Reymond,Lyssia Gruaz et al.
Marta García-Arauzo et al.
Proteomic and transcriptomic analyses of cerebrospinal fluid (CSF)-derived extracellular vesicles (EVs) offer unique insights into molecular changes associated with central nervous system (CNS) diseases and may result in biomarker identific...
Gut Microbiota and Bacterial Extracellular Vesicles: Emerging Roles in Myocardial Remodelling and Cardiac Health [0.03%]
肠道微生物群和细菌胞外囊泡：在心肌重塑和心脏健康中的新兴作用
Mingyang Chang,Tiantian Xia,Nan Zhang et al.
Mingyang Chang et al.
The gut microbiota, a collection of microorganisms residing within the human gastrointestinal tract, exerts profound effects on the health of the host. In recent years, studies have revealed that the gut microbiota influences not only the f...
Profiling RNA Cargo in Extracellular Vesicles From hiPSC-Derived Neurons of Alzheimer's Disease Patients [0.03%]
阿尔茨海默病患者hiPSC来源神经元胞外囊泡的RNA载物分析
Ram Sagar,Yiyao Huang,Daiyun Dong et al.
Ram Sagar et al.
Alzheimer's disease (AD) is a major neurodegenerative disorder that affects more than 55 million people, with an incidence that is projected to triple by 2050. Despite continuous advancements in the field, reliable treatment and early detec...
Multiomics Profiling of Extracellular Vesicles Supports Their Involvement in Endothelial Senescence-Associated Vascular Dysfunction [0.03%]
外泌体多组学分析支持其参与内皮细胞衰老相关的血管功能障碍
Ryan E Hogans,Yun Lin,Gabriela Grigorean et al.
Ryan E Hogans et al.
Dysfunction of vascular endothelium is characteristic of many aging-related diseases, including Alzheimer's disease (AD) and AD-related dementias (ADRD). Although it is widely posited that endothelial cell dysfunction contributes to the pat...
Plasma Preparation Strategies for Extracellular Vesicle-Based Biomarkers in Metastatic Castration-Resistant Prostate Cancer [0.03%]
转移性去势抵抗性前列腺癌基于细胞外囊泡的生物标志物的血浆制备策略
Prima Dewi Sinawang,Priyanka Multani,Mehmet O Ozen et al.
Prima Dewi Sinawang et al.
Extracellular vesicles (EVs) offer a minimally invasive approach for cancer detection and monitoring. However, the lack of standardized methods for clinical biospecimen preparation and EV isolation limits the clinical utility of EV-based bi...
[This corrects the article DOI: 10.1002/jex2.70051.]. © 2025 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf...
Published Erratum
Journal of extracellular biology. 2025 Jul 24;4(7):e70070. DOI:10.1002/jex2.70070 2025
Extracellular Vesicle Mitochondrial DNA Levels Are Associated With Chronic Kidney Disease and Mitochondrial Haplogroup in Obese Individuals [0.03%]
肥胖人群外泌体线粒体DNA水平与慢性肾脏病及线粒体谱系类型相关性研究
Jaida E Morgan,Nicole Noren Hooten,Nicolle A Mode et al.
Jaida E Morgan et al.
Chronic kidney disease (CKD) and obesity are major chronic diseases in the United States. Although obesity is a risk factor for CKD, little is known about how obesity contributes to CKD. Due to their role as intercellular communicators, ext...
Quantum Dot-Based Immunolabelling of Extracellular Vesicles and Detection Using Fluorescence-Based Nanoparticle Tracking Analysis [0.03%]
基于量子点的免疫标记外泌体及其荧光检测技术
Eunyong Ha,Yewon Han,Minseop Kim et al.
Eunyong Ha et al.
Extracellular vesicles (EVs) contain a variety of biomolecules, including DNA, RNA, lipids and proteins. They can interact with target cells to perform various functions, offering potential for therapeutic applications like drug delivery an...
Cargo Analysis and MRI-Based Therapeutic Assessment of Iron Oxide Labelled Extracellular Vesicles of Hypoxia Human Stem Cells in Ischemic Stroke [0.03%]
缺氧人源干细胞释放的铁氧化物标记外泌体的载货分析及其基于MRI的中风再血管化治疗效应评估
Shannon Helsper,Li Sun,Richard Jeske et al.
Shannon Helsper et al.
Human mesenchymal stem cells (hMSCs) have been under investigation in preclinical and clinical settings for treating neurological disorders in recent years. Predominantly due to paracrine effects in vivo, hMSC-secreted extracellular vesicle...