Oral Delivery of Semaglutide and Tirzepatide Using Milk-Derived Small Extracellular Vesicles [0.03%]
利用牛奶源小细胞外囊泡口服递送司美格鲁肽和 tirzepatide
Yuefei Zhang,Jianyi Han,Wei Wu et al.
Yuefei Zhang et al.
Therapeutic proteins and peptides have revolutionized modern biomedicine, but their oral delivery is limited by gastrointestinal degradation and barriers. Small extracellular vesicles (sEVs), which are resistant to biochemical degradation a...
Single-Cell Analysis of L-Myc Expressing Neural Stem Cells and Their Extracellular Vesicles Revealed Distinct Progenitor Populations With Neurogenic Potential [0.03%]
单细胞分析L-Myc表达神经干细胞及其外泌体发现了具有神经生成潜能的不同祖细胞群
Patrick Pirrotte,Yate-Ching Yuan,Nathaniel P Hansen et al.
Patrick Pirrotte et al.
Neural stem cell (NSC)-based therapies offer a promising strategy to promote brain repair by delivering neurotrophic factors, supporting cell replacement, and stimulating endogenous neurogenesis following injury. While numerous studies have...
Characterization of HIV-1 Particles Co-Purified With Three Extracellular Vesicle Subtypes From the Raji CD4 DCIR Cell Line, a Hybrid Model of CD4 T Cells and Dendritic Cells [0.03%]
来自Raji CD4 DCIR细胞系的三种胞外囊泡亚型共纯化的HIV-1颗粒的表征，一个CD4 T细胞和树突状细胞杂交模型
Julien Boucher,Alyssa Rousseau,Caroline Gilbert
Julien Boucher
HIV-1 proteins and RNA are incorporated into extracellular vesicles (EVs) via the EV biogenesis machinery. Due to their similar size and content, EVs and HIV-1 particles are hard to separate, and current purification methods often overlook ...
Enrichment of Immune Cell-Derived Extracellular Vesicles From Plasma Using 35 and 70 nm Size-Exclusion Chromatography Columns of Different Sizes [0.03%]
基于不同尺寸的35和70nm排阻色谱柱富集血浆中免疫细胞来源的外泌体研究
Iris Potakowskyj,Ivan Bagarić,Nevena Prodanović et al.
Iris Potakowskyj et al.
Extracellular vesicles (EVs) from blood plasma are promising biomarkers, as they carry surface markers indicative of their cell of origin. Size-exclusion chromatography (SEC) is commonly employed for EV enrichment, but the choice of pore si...
Dissemination of Mitochondrial DNA Variants: Looking at the 'Bigger' Picture of the Tumour Microenvironment in Rectal Cancer Patients [0.03%]
结直肠癌患者的肿瘤微环境：“更大的”观察视角——线粒体DNA变异的传播
Kine Mari Bakke,Tonje Bjørnetrø,Paula A Bousquet et al.
Kine Mari Bakke et al.
The tumour microenvironment (TME) constitution is decisive for cancer outcome and is manifested in diffusion-weighted (DW) magnetic resonance imaging (MRI). We hypothesized that the TME metabolic state is reflected by mitochondrial DNA (mtD...
Extracellular Vesicles From a Model of Melanoma Cancer-Associated Fibroblasts Induce Changes in Brain Microvascular Cells Consistent With Pre-Metastatic Niche Priming [0.03%]
黑色素瘤癌相关成纤维细胞来源的细胞外囊泡诱导脑微血管细胞发生变化以适应预转移生态龛的形成
Mikayla Shelton,Chinedu A Anene,Jeremie Nsengimana et al.
Mikayla Shelton et al.
Malignant melanoma has one of the lowest 5-year survival rates of any cancer and is characterised by its high invasiveness and metastatic potential, with especially poor outcomes in patients who develop brain metastases. Crosstalk between m...
Correction to "Generalizability of Enzyme-Based Isolation Approach for Extracellular Vesicles from Traditional Medicinal Plants" [0.03%]
特医植物外泌体酶法提取通用性的商榷
[This corrects the article DOI: 10.1002/jex2.70090.]. © 2025 The Author(s). Journal of Extracellular Biology published by Wiley Periodicals, LLC on beha...
Published Erratum
Journal of extracellular biology. 2025 Oct 30;4(11):e70096. DOI:10.1002/jex2.70096 2025
Two Sides of the Same Coin-Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host-Derived Extracellular Vesicles [0.03%]
同出一源 two sides of the same coin-细菌和宿主来源的外泌体的机制阐释、诊断应用及治疗转化
Philipp Arnold,Fanni Annamária Boros,Jochen Mattner et al.
Philipp Arnold et al.
Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular commu...
Direct Experimental Evidence for Selective Uptake of Function-Specific Small Extracellular Vesicles by Recipient Cells [0.03%]
功能特异性外泌体选择性进入靶细胞的直接实验证据
Yuhong Liu,Natsumi Tiffany Ishii,Jun-Yu Dong et al.
Yuhong Liu et al.
Small extracellular vesicles (sEVs), ranging from 30 to 200 nm in diameter, are a subset of extracellular vesicles that play an essential role in intercellular communication by transporting bioactive molecules between cells. Due to their di...
Outer Membrane Vesicles From Bacteroides fragilis Contain Coding and Non-Coding Small RNA Species That Modulate Inflammatory Signalling in Intestinal Epithelial Cells [0.03%]
脆弱拟杆菌外膜囊泡中含有编码和非编码的小RNA，可调节肠道上皮细胞的炎性信号通路
Aadil Sheikh,Colin Scano,Julia Xu et al.
Aadil Sheikh et al.
Alterations to the community structure and function of the microbiome are associated with changes to host physiology, including immune responses. However, the contribution of microbe-derived RNAs carried by outer membrane vesicles (OMVs) to...