Mammary Fibroblasts Secrete Damage Associated Molecular Patterns Through Extracellular Vesicles in Response to Ionizing Radiation [0.03%]
辐射诱导的乳腺纤维母细胞通过细胞外囊泡释放损伤相关分子模式
Greg Berumen Sánchez,Purvi Patel,Preston Gomez-Crase et al.
Greg Berumen Sánchez et al.
Ionizing radiation (IR) is an integral component of cancer therapy. Cellular exposure to IR typically leads to major biological consequences including cell death and senescence. Furthermore, tissue injury is known to involve the release of ...
BioProEV: A Bioinformatics Pipeline for Biologically-Relevant Handling of Missing Values in the Analysis of Extracellular Vesicles by Mass Spectrometry [0.03%]
生物相关信息缺失值处理的外泌体质谱分析生物信息学流程BioProEV
Pâmella Miranda,Jose G Marchan-Alvarez,Annemarijn Offens et al.
Pâmella Miranda et al.
While proteomics is being increasingly applied to investigate extracellular vesicles (EVs), there remains no consensus on how to address the inevitable missing values within proteomics datasets. Here, we devised a three-step approach that p...
Exercise and Skeletal Muscle-Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation [0.03%]
运动与骨骼肌源性外泌体：其内容物、释放及代谢调节作用
Jeremy Boulestreau,Scott K Ferguson,Luke Nelson et al.
Jeremy Boulestreau et al.
The health benefits of exercise are well established in the prevention and management of metabolic disorders such as obesity and diabetes. Emerging evidence indicates that extracellular vesicles (EVs) may contribute to the beneficial effect...
Phosphate Limitation Modulates Vibrio Cholerae Outer Membrane Vesicle Formation, Composition and Toxicity [0.03%]
磷限制调节霍乱弧菌外膜囊泡的形成、组成和毒性
Matheus Luchetta da Fonseca,Livia Carvalho Barbosa,Beatriz Ferreira de Carvalho Patricio et al.
Matheus Luchetta da Fonseca et al.
Vibrio cholerae inhabits phosphorus-poor aquatic environments and host intestine, where it expresses genes regulated by the PhoB/PhoR two-component system in response to inorganic phosphate (Pi) limitation. Like other Gram-negative bacteria...
Biomolecular Corona Remodelling of Aspergillus fumigatus Extracellular Vesicles Shapes Immune Recognition and Macrophage Activation Programs [0.03%]
烟曲霉细胞外囊泡生物分子重排重塑免疫识别和巨噬细胞活化程序
Lucas Fabrício Bahia Nogueira,Bianca T M de Oliveira,Renan E A Piraine et al.
Lucas Fabrício Bahia Nogueira et al.
Extracellular vesicles (EVs) released by Aspergillus fumigatus play key roles in fungal-host communication. Similar to synthetic nanoparticles, fungal EVs acquire a biomolecular corona composed of a tightly bound "hard" corona layer of fung...
Proteomic and Super-Resolution Analyses of Murine Brown Adipocyte-Derived Extracellular Vesicles [0.03%]
小鼠棕色脂肪细胞源性外泌体的蛋白组学及超分辨率分析研究
Menchus Quan,Yi-Kai Liu,Maryam Mahmoodi et al.
Menchus Quan et al.
Thermogenic brown adipocytes (BAs) are not only an energy sink but also regulate systemic metabolic health through secreted factors and extracellular vesicles (EVs). Here, we investigate the baseline profiles BA-EVs and how cold-induced the...
Heparan Sulphate Glycosaminoglycan Chains Contribute to the Tethering of Coronal Factors and Are Important for Extracellular Vesicle-Mediated Fibroblast Activation [0.03%]
硫酸肝素糖胺聚糖链有助于冠状因子的牵引并参与细胞外囊泡介导的成纤维细胞活化
Sara Veiga,Alex P Shephard,Kate Milward et al.
Sara Veiga et al.
Extracellular vesicles (EVs) play a critical role in intercellular communication, yet the contribution of the EV corona and associated surface structures, such as heparan sulphate glycosaminoglycan (HS GAG) chains, to EV function remains po...
Flow Cytometric Detection of Biomarker Changes in CFDA-SE-Labelled Plasma Extracellular Vesicles Using a Rodent Pregnancy Model of Prenatal Diagnostics [0.03%]
基于 rodents 妊娠模型的母体诊断用CFDA-SE标记的血浆外泌体的流式检测技术及生物标志物变化分析
Petra Adamova,Lesley Sloan,Andrew K Powell et al.
Petra Adamova et al.
Circulating extracellular vesicles (EVs) offer a promising source of non-invasive biomarkers for congenital disease diagnostics but robust assays for their detection are lacking. We used a rodent pregnancy model as a proxy for a prenatal di...
A Syndecan-Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies [0.03%]
基于 syndecan 的遗传方法，使用纳米体包被小型细胞外囊泡的表面
Lukas Hyka,Sofie Meeussen,Rania Ghossoub et al.
Lukas Hyka et al.
Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited. Here, we present a reliable and simple genetic approach that enables customized...