ADAM10-Mediated Proteolytic Remodelling of Signalling and Adhesion Proteins on Brain Cell-Derived Small Extracellular Vesicles [0.03%]
ADAM10介导的脑细胞来源的小胞外囊泡中信号传导和粘附蛋白的蛋白水解重塑作用
Christopher C Reimann,Hermann C Altmeppen,Tomas Koudelka et al.
Christopher C Reimann et al.
Proteases are common components of extracellular vesicles (EVs), yet the extent and functional relevance of ongoing proteolytic activity on EV surfaces remain largely unexplored. Such activity could significantly influence EV function and i...
Circulating Tumour DNA and Extracellular Vesicle-Associated DNA as Biomarkers for Cancer Detection: A Systematic Review and Meta-Analysis [0.03%]
循环肿瘤DNA和细胞外囊泡相关DNA作为癌症检测生物标志物的系统评价和meta分析
Tad Wu,Kyle Dickinson,Ian Schiller et al.
Tad Wu et al.
Liquid biopsy is an emerging tool that allows the detection and monitoring of tumours through the analysis of various analytes in biofluids like blood. An important component of liquid biopsy is circulating tumour (ct) DNA, small fragments ...
Comparative Proteomic Profiling of Clinical Klebsiella pneumoniae Strains and the Corresponding Outer Membrane Vesicles [0.03%]
临床分离的肺炎克雷伯氏菌及其外膜囊泡的蛋白质组学分析
Zongping Li,Jingyuan Xi,Xinmiao Jia et al.
Zongping Li et al.
Klebsiella pneumoniae (K. pneumoniae) has become a global threat due to the convergence of carbapenem resistance and hypervirulence. Outer membrane vesicles (OMVs) play important roles in bacterial pathogenicity, yet their functional coordi...
Generation of Nano-Antibodies Targeting the SNMP1 Membrane Receptor of Spodoptera littoralis Using Extracellular Vesicles [0.03%]
使用细胞外囊泡生成针对Spodoptera littoralis SNMP1膜受体的纳米抗体
Alexis Dogliani,Laura Fradale,Céline Valeille et al.
Alexis Dogliani et al.
Handling membrane proteins (MPs) in their native environment is crucial for ensuring proper folding and stability. Extracellular vesicles (EVs) offer a superior alternative to detergents and artificial lipid environments. Expressing recombi...
Beyond miRNA Cargo Profiles: Anti-Inflammatory Roles of Extracellular Vesicle-Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing [0.03%]
超越miRNA载荷谱型：功能性试验揭示人类椎间盘细胞衍生的外泌体富集的miRNA的抗炎作用
Li Li,Aiwei Sun,Saber Ghazizadeh et al.
Li Li et al.
Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain and a major contributor to global disability. Understanding the molecular mechanisms underlying this condition is essential for developing targeted therapies...
Glioblastoma Cells Expressing Oncogenic EGFR Release Multiple Extracellular Vesicle Subpopulations Positive or Negative for EGFR [0.03%]
表达致癌表皮生长因子受体的胶质母细胞瘤细胞释放多种带有或不带EGFR的 extracellular vesicle 子群
Elham Pishavar,Fereshteh Shojaei-Ghahrizjani,Brian Meehan et al.
Elham Pishavar et al.
Extracellular vesicle (EV) heterogeneity is well documented but poorly defined. This is especially important in cancer where EVs serve as carriers of unique oncogenic macromolecules that can be transferred to recipient cells or targeted for...
Ultracentrifugation and Ultrafiltration Differentially Alter the Composition and Functionality of the Biomolecular Corona of Extracellular Vesicles [0.03%]
超速离心与超滤技术如何改变细胞外囊泡生物分子冠的组成和功能性的研究
Frederic St-Denis-Bissonnette,Hala Halabi,Marybeth Creskey et al.
Frederic St-Denis-Bissonnette et al.
While extracellular vesicles (EVs) are increasingly recognized for their diagnostic and therapeutic potential, many unknowns remain. An emerging and important concept in EV biology is the EV biomolecular corona, a dynamic layer of absorbed ...
A One-Step Workflow for Size-Based Separation of Extracellular Vesicles With Integrated Surface Marker Detection [0.03%]
一步式 workflow 基于尺寸的分离外泌体及其表面标志物检测
Lien Lippens,Niké Guilbert,Sofie Van Dorpe et al.
Lien Lippens et al.
Extracellular vesicles (EVs) are released by diverse cell types in biofluids and are increasingly studied in liquid biopsies as diagnostic and prognostic biomarkers for various diseases, including cancer. Typically, the analysis of EV-assoc...
Proteomic Epithelial-To-Mesenchymal Transition Signature in Fetoplacental Small Extracellular Vesicles of Early-Onset Preeclampsia [0.03%]
早发子痫前期胎盘外泌体蛋白质组上皮间质转化标志物的筛选及验证研究
Michaela Stoiber,Monika Horvat Mercnik,Birgit Hirschmugl et al.
Michaela Stoiber et al.
Preeclampsia (PE), a hypertensive disorder in pregnancy, is linked to placental vascular remodelling, increasing risks of foetal growth restriction and long-term offspring health problems. The role of fetoplacental endothelial cell-derived ...
Small Extracellular Vesicles in Gestational Diabetes Mellitus: Current Landscape and Emerging Diagnostic Horizons [0.03%]
妊娠期糖尿病中小细胞外囊泡的现状和新兴诊断前景
Mai Ahmed,Dada Oluwaseyi Temilola,Mushi Matjila et al.
Mai Ahmed et al.
Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Current diagnostic strategies, particularly the oral glucose tolerance test (OGTT), a...