Small extracellular vesicles are released ex vivo from platelets into serum and from residual blood cells into stored plasma [0.03%]
体外血小板向血清和储存血浆中释放小型细胞外囊泡
Małgorzata S Małys,Maximilian C Köller,Kristin Papp et al.
Małgorzata S Małys et al.
Small extracellular vesicles (sEV) purified from blood have great potential clinically as biomarkers for systemic disease; however interpretation is complicated by release of sEV ex vivo after blood taking. To quantify the problem and devis...
Multimode chromatography-based techniques for high purity isolation of extracellular vesicles from human blood plasma [0.03%]
基于多模式色谱技术的从人血浆中分离高纯度细胞外囊泡的方法
Alan J Zimmerman,Getulio Pereira de Oliveira Jr,Xianyi Su et al.
Alan J Zimmerman et al.
Extracellular vesicles (EVs) play a pivotal role in various biological pathways, such as immune responses and the progression of diseases, including cancer. However, it is challenging to isolate EVs at high purity from blood plasma and othe...
Prostate-derived circulating microRNAs add prognostic value to prostate cancer risk calculators [0.03%]
前列腺来源的循环microRNAs增加了前列腺癌风险预测模型的预后价值
Morgan L Zenner,Brenna Kirkpatrick,Trevor R Leonardo et al.
Morgan L Zenner et al.
Prostate cancer is the second leading cause of malignancy-related deaths among American men. Active surveillance is a safe option for many men with less aggressive disease, yet definitively determining low-risk cancer is challenging with bi...
Protein palmitoylation regulates extracellular vesicle production and function in sepsis [0.03%]
蛋白质棕榈酰化调节脓毒症中外泌体的生成及功能
Xiaoyuan Yang,Ethan Zheng,Victor Chatterjee et al.
Xiaoyuan Yang et al.
Extracellular vesicles (EVs) are bioactive membrane-encapsulated particles generated by a series of events involving membrane budding, fission and fusion. Palmitoylation, mediated by DHHC palmitoyl acyltransferases, is a lipidation reaction...
International Society for Extracellular Vesicles Workshop. QuantitatEVs: multiscale analyses, from bulk to single extracellular vesicle [0.03%]
国际细胞外囊泡学会研讨会。QuantitatEVs：多尺度分析，从大量到单个细胞外囊泡
Manuela Basso,Alessandro Gori,Caterina Nardella et al.
Manuela Basso et al.
The 'QuantitatEVs: multiscale analyses, from bulk to single vesicle' workshop aimed to discuss quantitative strategies and harmonized wet and computational approaches toward the comprehensive analysis of extracellular vesicles (EVs) from bu...
Crosstalk between tumor and stroma modifies CLIC4 cargo in extracellular vesicles [0.03%]
肿瘤和间质的串扰改变了细胞外囊泡中的CLIC4货物
Vanesa C Sanchez,Alayna Craig-Lucas,Christophe Cataisson et al.
Vanesa C Sanchez et al.
Mouse models of breast cancer have revealed that tumor-bearing hosts must express the oxidoreductase CLIC4 to develop lung metastases. In the absence of host CLIC4, primary tumors grow but the lung premetastatic niche is defective for metas...
Blebs and former blebs: From surface protrusions to extracellular vesicles in cancer signalling, anoikis resistance and beyond [0.03%]
从表面突起到胞外囊泡：在癌症信号，厌氧菌抵抗等方面的研究
Dolores Di Vizio,Melanie Schoppet,Ashani Weeraratna et al.
Dolores Di Vizio et al.
Associations between plasma membrane blebbing and metastatic progression have been widely reported. There are also reports of increased extracellular vesicle release from cancer cells. Yet the ties between these closely related phenomena ar...
Polarized Desmosome and Hemidesmosome Shedding via Small Extracellular Vesicles is an Early Indicator of Outer Blood-Retina Barrier Dysfunction [0.03%]
极化半桥粒和半桥粒通过小型细胞外囊泡脱落是外层血视网膜屏障功能障碍的早期指标
Belinda J Hernandez,Nikolai P Skiba,Karolina Plössl et al.
Belinda J Hernandez et al.
The retinal pigmented epithelium (RPE) constitutes the outer blood-retinal barrier, enables photoreceptor function of the eye, and is constantly exposed to oxidative stress. As such, dysfunction of the RPE underlies pathology leading to dev...
Integrating extracellular vesicle and circulating cell-free DNA analysis using a single plasma aliquot improves the detection of HER2 positivity in breast cancer patients [0.03%]
使用单一血浆样本结合分析细胞外囊泡和循环游离DNA可改善乳腺癌患者HER2阳性的检测率
Vera Mugoni,Yari Ciani,Orsetta Quaini et al.
Vera Mugoni et al.
Multi-analyte liquid biopsies represent an emerging opportunity for non-invasive cancer assessment. We developed ONCE (One Aliquot for Circulating Elements), an approach for the isolation of extracellular vesicles (EV) and cell-free DNA (cf...
Human red blood cells release microvesicles with distinct sizes and protein composition that alter neutrophil phagocytosis [0.03%]
人红细胞释放大小和蛋白质组成各异的微囊体可改变中性粒细胞的吞噬作用
Getulio Pereira de Oliveira Junior,Joshua A Welsh,Brandy Pinckney et al.
Getulio Pereira de Oliveira Junior et al.
Extracellular vesicles (EVs) are membrane-bound structures released by cells and tissues into biofluids, involved in cell-cell communication. In humans, circulating red blood cells (RBCs), represent the most common cell-type in the body, ge...