Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis [0.03%]
蓝氏贾第鞭毛虫细胞外囊泡：解开其毒力因子和潜在的预防实验性贾第鞭毛虫病的能力
Corral-Ruiz Gerardo,Argüello-García Raúl,Ortiz-Lozano Dalia et al.
Corral-Ruiz Gerardo et al.
Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans-kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host-pathogen in...
HIV Tat-Stimulated Microglial Extracellular Vesicles Are Enriched for Ferroptosis Mediators: Role of Dysregulated Autophagy [0.03%]
HIV-Tat激活的小胶质细胞外泌体富含铁死亡介质：自噬失调的作用
Seema Singh,Elias Horanieh,Craig L Semerad et al.
Seema Singh et al.
Extracellular vesicles (EVs) serve as conduits for intercellular communication, under both physiological and pathological contexts. During disease pathogenesis, microglia-derived EVs (MEVs) play a key role in transferring pathological cargo...
Extracellular Vesicle-Associated IL4 Displays Enhanced Anti-Inflammatory Properties in Microglial Cells [0.03%]
外泌体相关IL4在小胶质细胞中表现出增强的抗炎作用
Giulia Marostica,Chiara Frigè,Annamaria Finardi et al.
Giulia Marostica et al.
Neuroinflammation and neurodegeneration are strictly related phenomena, characterized by dysregulation of microglia, central nervous system (CNS) resident immune cells. Interleukin-4 (IL4) has shown beneficial abilities to re-establish micr...
Evaluating Variability in Extracellular Vesicle Characterization Across Measurement Techniques [0.03%]
评估不同测量技术在外泌体特征化中的变异性
Premanshu K Singh,Ali F Usmani,Debmalya Halder et al.
Premanshu K Singh et al.
Reliable, reproducible, and standardized characterization of extracellular vesicles (EVs) remains a central challenge due to methodological variability across analytical platforms and intrinsic EV heterogeneity within and across biofluids. ...
Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High-Grade Glioma - Emerging Findings and Opportunities [0.03%]
外泌体在儿童高级别胶质瘤的生物学和液体活检诊断中的新发现及应用机遇
Samia Jahouri,Laura Montermini,Nadim Tawil et al.
Samia Jahouri et al.
Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). ...
Long-Term Stability of Bacterial Extracellular Vesicles Stored at Different Temperatures [0.03%]
不同温度下储存的细菌胞外囊泡的长期稳定性
Anagha Rama Varma,Frank Borris,Parnika Kant et al.
Anagha Rama Varma et al.
Extracellular vesicle (EV) research has revealed EV involvement in a variety of biological processes, with potential applications in both fundamental research and therapeutic development. EVs of bacterial origin have been implicated in host...
Single-EV Analyses Require Rigorous Antibody Qualification: PD-L1 Profiling in Cell Models and Patient Plasma [0.03%]
单EV分析需要严格的抗体鉴定：细胞模型和患者血浆中的PD-L1谱型分析
Tobias Tertel,Fabiola Nardi Bauer,Oumaima Stambouli et al.
Tobias Tertel et al.
Imaging flow cytometry (IFCM) has emerged as a powerful method for high-throughput phenotyping of small extracellular vesicles (sEVs) at single-vesicle resolution. However, the reliability and sensitivity of IFCM critically depend on the pe...
Mammary Fibroblasts Secrete Damage Associated Molecular Patterns Through Extracellular Vesicles in Response to Ionizing Radiation [0.03%]
辐射诱导的乳腺纤维母细胞通过细胞外囊泡释放损伤相关分子模式
Greg Berumen Sánchez,Purvi Patel,Preston Gomez-Crase et al.
Greg Berumen Sánchez et al.
Ionizing radiation (IR) is an integral component of cancer therapy. Cellular exposure to IR typically leads to major biological consequences including cell death and senescence. Furthermore, tissue injury is known to involve the release of ...
BioProEV: A Bioinformatics Pipeline for Biologically-Relevant Handling of Missing Values in the Analysis of Extracellular Vesicles by Mass Spectrometry [0.03%]
生物相关信息缺失值处理的外泌体质谱分析生物信息学流程BioProEV
Pâmella Miranda,Jose G Marchan-Alvarez,Annemarijn Offens et al.
Pâmella Miranda et al.
While proteomics is being increasingly applied to investigate extracellular vesicles (EVs), there remains no consensus on how to address the inevitable missing values within proteomics datasets. Here, we devised a three-step approach that p...