Mechanical property estimation of sarcoma-relevant extracellular vesicles using transmission electron microscopy [0.03%]
透射电子显微镜在与肉瘤相关的细胞外囊泡机械性能估计中的应用
Premanshu Kumar Singh,Patricia Sarchet,Catherine Hord et al.
Premanshu Kumar Singh et al.
Analysis of single extracellular vesicles (EVs) has the potential to yield valuable label-free information on their morphological structure, biomarkers and therapeutic targets, though such analysis is hindered by the lack of reliable and qu...
P2RX7 plays a critical role in extracellular vesicle-mediated secretion of pathogenic molecules from microglia and astrocytes [0.03%]
P2RX7在小胶质细胞和星形胶质细胞病原分子的外泌体介导分泌过程中发挥关键作用
Mohammad Abdullah,Zhi Ruan,Seiko Ikezu et al.
Mohammad Abdullah et al.
Extracellular vesicle (EV) secretion is mediated by purinergic receptor P2X7 (P2RX7), an ATP-gated cation channel highly expressed in microglia. We have previously shown that administration of GSK1482160, a P2RX7 selective inhibitor, suppre...
Acute neuroinflammation promotes a metabolic shift that alters extracellular vesicle cargo in the mouse brain cortex [0.03%]
急性神经炎症会促进代谢转换从而改变小鼠大脑皮层的细胞外囊泡货物组成
Natasha Vassileff,Jereme G Spiers,Juliani Juliani et al.
Natasha Vassileff et al.
Neuroinflammation is initiated through microglial activation and cytokine release which can be induced through lipopolysaccharide treatment (LPS) leading to a transcriptional cascade culminating in the differential expression of target prot...
Towards IVDR-compliance by implementing quality control steps in a quantitative extracellular vesicle-miRNA liquid biopsy assay for response monitoring in patients with classic Hodgkin lymphoma [0.03%]
通过在定量细胞外囊泡-miRNA液体活检测定中实施质量控制步骤以符合IVDR的要求，用于经典霍奇金淋巴瘤患者的反应监测
Esther E E Drees,Nils J Groenewegen,Sandra A W M Verkuijlen et al.
Esther E E Drees et al.
Previously, we showed that quantification of lymphoma-associated miRNAs miR-155-5p, -127-3p and let-7a-5p levels in plasma extracellular vesicles (EVs) report treatment response in patients with classic Hodgkin lymphoma (cHL). Prior to clin...
Characterisation of extracellular vesicles in baculovirus infection of Spodoptera frugiperda cells [0.03%]
草地夜蛾细胞杆状病毒感染的胞外囊泡表征研究
Lex J C Van Es,Robert D Possee,Linda A King
Lex J C Van Es
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is an enveloped DNA virus of the Baculoviridae family. This baculovirus is widely exploited for the biological control of insect pest species and as an expression platform to pro...
Characterisation of sRNAs enriched in outer membrane vesicles of pathogenic Flavobacterium psychrophilum causing Bacterial Cold Water Disease in rainbow trout [0.03%]
外膜囊泡富集的小sRNA的特征研究及其对虹彩病毒(Flavobacterium psychrophilum)引起鱼类冷水病的表征作用
Pratima Chapagain,Ali Ali,Destaalem T Kidane et al.
Pratima Chapagain et al.
Flavobacterium psychrophilum (Fp) causes Bacterial Cold Water Disease in salmonids. During host-pathogen interactions, gram-negative bacteria, such as Fp, release external membrane vesicles (OMVs) harbouring cargos, such as DNA, RNA and vir...
Amniotic fluid-derived small extracellular vesicles for predicting postnatal severe outcome of congenital diaphragmatic hernia [0.03%]
羊水来源的小细胞外囊泡用于先天性膈疝患儿出生后严重预后的预测
Seiko Matsuo,Akira Yokoi,Kosuke Yoshida et al.
Seiko Matsuo et al.
Congenital diaphragmatic hernia (CDH) is a life-threatening condition with high morbidity and mortality rates. The survival rate of neonates with severe CDH is reportedly only 10%-15%. However, prenatal prediction of severe cases is difficu...
Chemo-small extracellular vesicles released in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function [0.03%]
顺铂耐药卵巢癌细胞释放的化疗小细胞外囊泡受溶酶体功能调控
Cristóbal Cerda-Troncoso,Felipe Grünenwald,Eloísa Arias-Muñoz et al.
Cristóbal Cerda-Troncoso et al.
Chemoresistance is a common problem in ovarian cancer (OvCa) treatment, where resistant cells, in response to chemotherapy, secrete small extracellular vesicles (sEVs), known as chemo-sEVs, that transfer resistance to recipient cells. sEVs ...
Proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Impact of isolation methods on protein cargo [0.03%]
间充质干细胞源外泌体的蛋白质组学分析及不同分离方法对外泌体蛋白组成的影响
Morteza Abyadeh,Shahab Mirshahvaladi,Sara Assar Kashani et al.
Morteza Abyadeh et al.
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are secreted by cells and play a critical role in cell-to-cell communication. Despite the promising reports regarding their diagnostic and therapeutic potential, ...
Bone marrow-fibroblast progenitor cell-derived small extracellular vesicles promote cardiac fibrosis via miR-21-5p and integrin subunit αV signalling [0.03%]
骨髓成纤维细胞前体细胞来源的小细胞外囊泡通过miR-21-5p和整合素αV信号促进心脏纤维化
Prabhat Ranjan,Roshan Kumar Dutta,Karen Colin et al.
Prabhat Ranjan et al.
Cardiac fibrosis is the hallmark of cardiovascular disease (CVD), which is leading cause of death worldwide. Previously, we have shown that interleukin-10 (IL10) reduces pressure overload (PO)-induced cardiac fibrosis by inhibiting the recr...