Effects of electric fields on the release and content of extracellular vesicles [0.03%]
电场对细胞外囊泡释放及其内容物的影响
Yihua Wang,Gregory A Worrell,Hai-Long Wang
Yihua Wang
Extracellular vesicles (EVs) are small membrane-bound structures that originate from various cell types and carry molecular cargos to influence the behaviour of recipient cells. The use of EVs as biomarkers for diagnosis and as delivery veh...
Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type-2 diabetes [0.03%]
胰岛细胞中多囊泡体和分泌颗粒的定位及释放比较：2 型糖尿病期间的调控失衡
Priyadarshini Veerabhadraswamy,Kiran Lata,Sristi Dey et al.
Priyadarshini Veerabhadraswamy et al.
Multivesicular bodies (MVBs) are vesicles of endosomal origin containing intraluminal vesicles, which upon fusion with plasma membrane, secrete exosomes. They play a significant role in the physiology and pathology of type-2 diabetes (T2D) ...
Michael A Harding,Hayrettin Yavuz,Annika Gathmann et al.
Michael A Harding et al.
Urinary extracellular vesicles (uEVs) are a promising substrate for discovering new biomarkers. In order to investigate the origin of uEVs and the cargo they carry, some types of downstream analysis of uEVs may require concentration and enr...
Assessment of bovine milk exosome preparation and lyophilized powder stability [0.03%]
评价牛乳外泌体的制备及其冻干粉稳定性
Lu Lu,Chunle Han,Miao Wang et al.
Lu Lu et al.
Exosomes are cell-derived nanovesicles that play a crucial role in intercellular communication, presenting promising potential as biomarkers and therapeutic agents. Bovine milk exosomes (MK-Exo) show production scalability and cost-effectiv...
Size matters: Biomolecular compositions of small and large extracellular vesicles in the urine of glioblastoma patients [0.03%]
大小有别：胶质母细胞瘤患者尿液中微小及大型细胞外囊泡的生物分子组成
Susannah M Hallal,Liam A Sida,Csilla Ágota Tűzesi et al.
Susannah M Hallal et al.
The promise of urinary extracellular vesicles (uEVs) in biomarker discovery is emerging. However, the characteristics and compositions of different uEV subpopulations across normal physiological and pathological states require rigorous expl...
Hepatocyte-derived extracellular vesicles regulate liver regeneration through a negative feedback mechanism [0.03%]
肝细胞源性细胞外囊泡通过负反馈机制调节肝脏再生
Mina McGinn,Christopher Rabender,Ross Mikkelsen et al.
Mina McGinn et al.
While significant progress has been made in understanding various aspects of liver regeneration, the molecular mechanisms responsible for the initiation and termination of cell proliferation in the liver following massive tissue loss or inj...
New perspectives of the role of skeletal muscle derived extracellular vesicles in the pathogenesis of amyotrophic lateral sclerosis: the 'dying back' hypothesis [0.03%]
骨骼肌源性外泌体在肌萎缩侧索硬化症发病机制中的作用的新视角：“逐步死亡”假说
Carolina Sbarigia,Sophie Rome,Luciana Dini et al.
Carolina Sbarigia et al.
Amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord, and is characterized by muscle weakness, paralysis and ultimately, respiratory failure. The exact cau...
Challenging the conventional wisdom: Re-evaluating Smpd3's role in extracellular vesicle biogenesis [0.03%]
挑战传统观点：重新评估SMPD3在细胞外囊泡生成中的作用
Marlies Burgelman,Pieter Dujardin,Anthony Willems et al.
Marlies Burgelman et al.
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off-target effect...
Proteome characterization of extracellular vesicles from human milk: Uncovering the surfaceome by a lipid-based protein immobilization technology [0.03%]
人乳外泌体蛋白组分析：采用基于脂质的蛋白质固定技术发现表面蛋白质组学资料
Emelie Ahlberg,Maria C Jenmalm,Anders Karlsson et al.
Emelie Ahlberg et al.
Breast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex fluid is rich in extracellular vesicles (EVs). Here, we have applied a microfluidic technology, lipid-based protein immobilizatio...
Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics [0.03%]
外泌体的胞吞机制及其对癌症治疗药物设计的影响
Stephanie R Jackson Cullison,Joseph P Flemming,Kubra Karagoz et al.
Stephanie R Jackson Cullison et al.
The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack ...