Hepatocellular carcinoma cell-derived small extracellular vesicle-associated CD147 serves as a diagnostic marker and promotes endothelial cell angiogenesis via the PI3K/Akt pathway [0.03%]
肝细胞癌细胞源性小胞外囊泡相关的CD147作为一个诊断标记并通过PI3K/Akt途径促进内皮细胞血管生成
De-Fa Huang,Wen-Juan Zhang,Jie Chen et al.
De-Fa Huang et al.
Aim: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. The process of HCC development is closely related to angiogenesis. Plasma exosomes have diagnostic value in many diseases and have become a c...
Consistency in bacterial extracellular vesicle production: key to their application in human health [0.03%]
细菌外泌体产量的一致性：其在人体健康中应用的关键因素
Ke Dai,Bo Liao,Xiaotian Huang et al.
Ke Dai et al.
Bacterial extracellular vesicles (BEVs) are naturally occurring functional structures that play critical roles in bacterial life processes. These vesicles, commonly known as outer membrane vesicles (OMVs), were first found to be released by...
CD63, a new therapeutical candidate for cholesterol homeostasis regulation through extracellular vesicles? [0.03%]
新型治疗靶点CD63通过细胞外囊泡调节胆固醇稳态吗？
Julien Saint-Pol,Laurence Fenart
Julien Saint-Pol
CD63 is a tetraspanin initially associated with late endosomes and contributes to numerous functions at the cell level, such as intracellular endosomal and lysosomal trafficking, adhesion, and motility. CD63 also plays a key role in the bio...
Yan Zhen,Harald Stenmark
Yan Zhen
Cytokines are released by cells in response to infections and tissue damage. A recent paper by Jiao et al. demonstrates that circulating monocytes release the cytokines tumor necrosis factor and Interleukin-6 encapsulated in large extracell...
Disease-specific signatures of circulating extracellular vesicles detected by the surface plasmon resonance imaging: a pilot study [0.03%]
基于表面等离子共振成像技术的循环细胞外囊泡疾病特异性标志物筛选及验证的初步研究
Tatsuki Shibuta,Yukichi Takada,Shiori Nishinosono et al.
Tatsuki Shibuta et al.
Aim: Cells in the human body release extracellular vesicles (EVs) into fluids, such as plasma, urine, and cerebrospinal fluid. EVs express tetraspanin family proteins (e.g., CD63, CD9, and CD81) and cell-specific antigens on their surface a...
The times they are AI-changing: AI-powered advances in the application of extracellular vesicles to liquid biopsy in breast cancer [0.03%]
时代在AI下正发生变革：人工智能驱动的外泌体液体活检技术在乳腺癌中的应用进展
Vanesa García-Barberán,María Elena Gómez Del Pulgar,Heidy M Guamán et al.
Vanesa García-Barberán et al.
Artificial intelligence (AI) is revolutionizing scientific research by facilitating a paradigm shift in data analysis and discovery. This transformation is characterized by a fundamental change in scientific methods and concepts due to AI's...
A milestone for the therapeutic EV field: FDA approves Ryoncil, an allogeneic bone marrow-derived mesenchymal stromal cell therapy [0.03%]
治疗性EV领域的里程碑：FDA批准Ryoncil（同种异体骨髓源间充质基质细胞疗法）
Bernd Giebel
Bernd Giebel
Small extracellular vesicles (sEVs) derived from mesenchymal stromal cells (MSCs) hold substantial promise for therapeutic applications, including immune modulation and tissue regeneration. However, challenges such as batch-to-batch variabi...
Lexie Shannon Holliday,John K Neubert,Xianrui Yang
Lexie Shannon Holliday
The signaling gas hydrogen sulfide (H2S) has recently been implicated in the regulation of bone remodeling and the maintenance of periodontal health. Exploring the underlying mechanisms for this regulation holds promise for the development ...
Unraveling the role of amphisomes in mast cell secretory granule fusion and exosome release [0.03%]
揭秘变形溶酶体在肥大细胞分泌小泡融合及外泌体释放中的作用
Irene Tsilioni
Irene Tsilioni
Mast cells (MCs) play a crucial role in immune responses by storing and releasing inflammatory mediators from secretory granules (SGs). The biogenesis, maturation, and fusion of these granules with the plasma membrane regulate inflammation,...
Md Mofizur Rahman,Lixue Wang,Yundi Chen et al.
Md Mofizur Rahman et al.
Aim: A PCR- and sequencing-free mutation detection assay facilitates cancer diagnosis and reduces over-reliance on specialized equipment. This benefit was highlighted during the pandemic when high demand for viral nucleic acid testing often...