Molecular profiling and functional analyses of umbilical cord mesenchymal stem cell-derived extracellular vesicles for dry eye diseases [0.03%]
人脐带间充质干细胞来源的外泌体分子分型及其干眼病功能分析研究
Qiao-Yu Hsu,Chia-Ni Hsiung,Hsin-Hung Cheng et al.
Qiao-Yu Hsu et al.
Aim: Dry eye disease (DED) is a multifactorial disorder characterized by tear film instability, ocular surface damage, and inflammation. This study investigates the molecular landscape and the therapeutic potential of umbilical cord mesench...
Mesenchymal stem cell-derived extracellular vesicles for dry eye disease: principles, progress, and challenges [0.03%]
间充质干细胞来源的外泌体治疗干眼病：原理、进展与挑战
Yuting Feng,Mingqi Zhang
Yuting Feng
Dry eye disease (DED) is a multifactorial ocular surface disorder characterized by disruption of tear film and/or ocular surface homeostasis that represents a significant global public health concern. This review summarizes the pathogenesis...
A multidimensional landscape of extracellular vesicle-mediated tumor drug resistance: mechanisms, biomarkers, engineered drug delivery, and clinical translation [0.03%]
外泌体介导的肿瘤耐药多维度图景：机制、生物标志物、工程化药物递送及临床转化研究进展
Zhiqin Fu,Yanting Kuang,Meichai Li et al.
Zhiqin Fu et al.
Tumor drug resistance is a major clinical challenge that limits the efficacy of chemotherapy, targeted therapy, and immunotherapy, thereby contributing to tumor recurrence, metastasis, and reduced overall patient survival rates. Recent stud...
Terpenoid-enriched Curcuma wenyujin nanovesicles for suppressing inflammation and restoring lipid homeostasis in MASH [0.03%]
富含姜黄素的温郁金纳诺微米粒对MASH高脂模型鼠抗炎及调脂作用研究
Lin Liu,Jiale Niu,Yulong Sun et al.
Lin Liu et al.
Aim: This study investigates the potential of Curcuma wenyujin-derived nanovesicles (CW-DNVs) to ameliorate metabolic dysfunction-associated steatohepatitis (MASH) and explores their underlying mechanism, focusing on hepatic macrophage accu...
Extracellular vesicles as indicators of environmental stress response in Lactiplantibacillus plantarum [0.03%]
植物乳杆菌分泌的胞外囊泡作为环境压力反应指示物的研究
Agnieszka Razim,Astrid Laimer-Digruber,Anna M Schmid et al.
Agnieszka Razim et al.
Aim: To determine how exposure to bile influences the production, physicochemical properties, and molecular composition of extracellular vesicles (EVs) released by the probiotic Lactiplantibacillus plantarum (L. plantarum) NCIMB 8826. Metho...
Stem cell extracellular vesicles for neuropsychiatric disorders and translation [0.03%]
神经精神疾病的干细胞细胞外囊泡作用及转化研究
Hengxiang Fan,Shunqi Wang,Zhi Li et al.
Hengxiang Fan et al.
Neuropsychiatric disorders represent a major global health challenge due to their high prevalence, chronic disability, and substantial socioeconomic burden. Although stem cell-based therapies offer regenerative potential, their clinical app...
Uncovering the dynamics of extracellular vesicle microRNA trafficking in multiple sclerosis: delivery, diversion and retention [0.03%]
揭开多发性硬化症中细胞外囊泡微RNA转运的动力学：递送、改道和滞留
Gemma C Stevenson,Manisha S Patil,Georges E R Grau
Gemma C Stevenson
Extracellular vesicles (EVs) are phospholipid-bound structures that carry a distinct repertoire of short, non-coding microRNAs (miRNAs). EV miRNA content differs across various diseases, including multiple sclerosis (MS). These observations...
Engineered bacterial extracellular vesicles as next-generation precision postbiotics: strategies, challenges and prospects [0.03%]
工程化细菌外泌体作为下一代精准活菌疗法：策略、挑战和前景
Jiali Chen,Qiyan Chen,Baoxian Li et al.
Jiali Chen et al.
Postbiotics, defined as inactivated microorganisms and/or their components conferring a health benefit, represent a paradigm shift from traditional probiotics by offering superior safety, stability, and precise dosing. Bacterial extracellul...
Quantification of EV-associated miRNA in liquid biopsies for biomarker signature development [0.03%]
液态活检中外泌体相关miRNA的定量以及用于生物标志物谱型开发的研究
Mia S C Yu,Christian Grätz,Dapi Menglin Chiang et al.
Mia S C Yu et al.
Extracellular vesicle (EV)-associated microRNAs (miRNAs) are promising minimally invasive biomarkers, as EV encapsulation protects miRNAs from degradation while preserving disease- and cell- type-specific expression patterns across diverse ...
Katarzyna Kowalik,Justyna Karkowska-Kuleta
Katarzyna Kowalik
Malassezia species were long regarded as microorganisms implicated exclusively in dermatological pathology. However, recent studies have further postulated a potential association between these fungi and systemic and non-cutaneous diseases,...