Extracellular vesicles as mediators of prostatic diseases: connecting function to diagnostic and therapeutic applications [0.03%]
外泌体作为前列腺疾病介质：连接功能与诊断和治疗应用
Julie Bishara,Morolake Morakinyo,Sharanjot Saini
Julie Bishara
Diseases of the prostate gland, including benign prostatic hyperplasia (BPH) and prostate cancer (PCa), affect a significant proportion of men worldwide. The incidence of these diseases increases with advancing age decreased quality of life...
Microbial extracellular vesicles in the lung: friends in health, agents in disease [0.03%]
肺部微生物外泌体：健康时的朋友，疾病中的使者
Marta Pagnini,Maria Conti,Giorgia Puddu et al.
Marta Pagnini et al.
Microbial extracellular vesicles (mEVs) are emerging as key mediators at the host-microbe interface in the lung, playing a remarkable dual role as both pathogenic drivers and therapeutic modulators. These nano-sized, membrane-bound structur...
Rehmannia glutinosa nanovesicles protect cardiomyoblasts from oxidative injury [0.03%]
地黄纳米囊泡通过改善线粒体功能保护心肌细胞抗氧化损伤
Huilan Fan,Shuang Zhao,Yunfeng Di et al.
Huilan Fan et al.
Aim: Oxidative stress is a key driver of cardiovascular disease, underscoring the need for safe and effective antioxidant therapies. This study aims to evaluate the cardioprotective potential of plant-derived nanovesicles (PDNVs) derived fr...
A novel extracellular vesicle isolation method based on cellulose nanofiber sheets [0.03%]
一种基于纤维素纳米纤维片的新颖细胞外囊泡分离方法
Yukari Nagao,Hiroaki Kajiyama,Akira Yokoi
Yukari Nagao
Extracellular vesicles (EVs) circulate in body fluids, carrying molecular cargo from their parent cells and exerting diverse biological functions. Consequently, they have attracted considerable attention as biomarkers for disease detection ...
Verification of the predictive value of EV-associated biomarkers MMP9 and CEACAM1 in rehabilitation of ischemic stroke [0.03%]
基质金属蛋白酶9和细胞黏附分子-1预测缺血性卒中康复的疗效价值的验证研究
Jiao Luo,You Cai,Yanling Cai et al.
Jiao Luo et al.
Aim: Extracellular vesicles (EVs) contribute to stroke rehabilitation by mediating intercellular signaling during inflammation and tissue repair. Here we report EV-associated surface proteins as potential biomarkers for predicting recovery ...
Human umbilical cord mesenchymal stem cell-derived nanovesicles ameliorate acute lung injury by hsa-let-7g-5p inhibition of NF-κB/NLRP3 pathway [0.03%]
人源脐带间充质干细胞来源的纳米囊泡通过抑制NF-κB/NLRP3通路的has-let-7g-5p缓解急性肺损伤
Yilin Huang,Yan Zeng,Ailin Wu et al.
Yilin Huang et al.
Aim: Acute lung injury (ALI), marked by vigorous inflammatory reactions and elevated incidence, is a grave clinical issue for which efficacious pharmaceutical interventions are still lacking. This research delves into the anti-inflammatory ...
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as a novel topical immunomodulatory therapy for psoriasis: bridging the therapeutic gap in moderate disease [0.03%]
间充质基质细胞源外泌体(MSC-EVs)作为治疗中度银屑病的新型免疫调节药物：弥合治疗差距的新希望
Thong Teck Tan,Kok Hian Tan,Sai Kiang Lim
Thong Teck Tan
Psoriasis is a chronic, immune-mediated inflammatory disease that affects approximately 2%-3% of the global population, and remains a major dermatologic and psychosocial burden. Despite advances in biologics targeting interleukin 17 (IL-17)...
Comparison of methods for isolation of extracellular vesicles from bronchoalveolar lavage fluid [0.03%]
比较从支气管肺泡灌洗液中分离外泌体的方法
Mark E Fraser,Radha Patel,Taylor Shinabery et al.
Mark E Fraser et al.
Aim: Extracellular vesicles (EVs) have been described and isolated from a variety of biological samples, including bronchoalveolar lavage (BAL). While EVs have been isolated from BAL by various methods, there has not been a comparative stud...
The regulatory landscape for extracellular vesicle therapies: Australian context and future directions [0.03%]
澳大利亚外泌体疗法的监管格局及未来方向
Christopher Rudge,Reeve McClelland,Wojciech Chrzanowski et al.
Christopher Rudge et al.
Extracellular vesicles (EVs) are emerging as promising tools for regenerative medicine and drug delivery, offering unique therapeutic advantages. However, their clinical translation - in Australia and globally - faces persistent challenges....
Impact of flow cytometry-based sorting on microRNA signature of extracellular vesicles derived from mesenchymal stromal cells: a proof-of-concept study [0.03%]
流式细胞仪分选对间充质基质细胞衍生的外泌体中microRNA特征的影响：概念验证研究
Enrico Ragni,Monica Romanò,Michela Maria Taiana et al.
Enrico Ragni et al.
Aim: This proof-of-concept study aimed to evaluate the impact of fluorescence-based sorting on the microRNA (miRNA) molecular profile of extracellular vesicles (EVs) derived from adipose-derived mesenchymal stromal cells (ASCs) (ASC-EVs), w...